Coenzyme q10
Supplement
vitamin-like compound
heart & metabolicenergy
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Fatigue: small pooled effect · heart trials mixed
Take with
HSA rule: not with warfarin without medical advice
Pros & cons
Pros
- 13-RCT meta-analysis: small drop in fatigue scores
- 1 gi adverse event among 602 CoQ10 participants
- HSA allows it in supplements, capped at 150 mg a day
Cons
- NCCIH: prevention and heart-failure data inconclusive
- Statin muscle pain: overall evidence does not support
- Heart trials are in diagnosed heart failure patients
Sources
- NIH NCCIH — Coenzyme Q10, Bottom Line (page last updated January 2019) · read 2026-08-27
what it says
“Only a few studies have looked at whether CoQ10 might help prevent heart disease, and their results are inconclusive. Research on the effects of CoQ10 in heart failure is also inconclusive.”
- NIH NCCIH — Coenzyme Q10, Bottom Line (statin muscle pain) · read 2026-08-27
what it says
“Although results of individual studies have varied, the overall scientific evidence does not support the idea that CoQ10 can reduce muscle pain caused by the cholesterol-lowering drugs known as statins.”
- NIH NCCIH — Coenzyme Q10, Safety section · read 2026-08-27
what it says
“Mild side effects such as insomnia or digestive upsets may occur. CoQ10 may interact with the anticoagulant (blood thinner) warfarin and the diabetes drug insulin, and it may not be compatible with some types of cancer treatment.”
- Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (Tsai et al., Front Pharmacol 2022;13:883251) — 13 RCTs, 1,126 participants; INPLASY202210113 · read 2026-08-27
what it says
“the CoQ10 group showed a statistically significant reduction in fatigue scores (Hedges' g = -0.398 … p = 0.001) … There was only one adverse (gastrointestinal) event in the 602 participants who underwent the CoQ10 intervention”
- Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials (BMC Cardiovasc Disord 2024;24:599) — 33 RCTs; PROSPERO CRD42023493184 · read 2026-08-27
what it says
“In total, 33 studies were included in this meta-analysis, which showed that all-cause mortality [RR = 0.64 … GRADE: moderate quality] … were lower in the coenzyme Q10 group than in the control group”
- HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 (October 2025), Annex A row 30 · read 2026-08-27
what it says
“30. Coenzyme Q10 — Restricted use in HS and TM. Maximum Daily Dose … the maximum recommended daily dose should not provide more than 150mg. Cautionary Statement … “Do not take while on warfarin therapy without medical advice.””
- HSA Singapore — Health Supplements Guidelines (January 2026), s4.8 and Tables 4–5 (vitamins and minerals only) · read 2026-08-27
what it says
“4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5”
- iHerb Singapore — CoQ10 category page, default (best-selling) order, SGD pricing · read 2026-08-27
what it says
“California Gold Nutrition, CoQ10, USP Grade Ubiquinone, 100 mg … Doctor's Best, High Absorption CoQ10, 100 mg … NOW Foods, CoQ10, 200 mg … Life Extension, Super Ubiquinol CoQ10 … Qunol, Mega CoQ10 Ubiquinol, 100 mg”
Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.