Cetirizine
Medication
antihistamine
allergy
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Runny nose, sneezing, itchy eyes/nose/throat, itchy rash
When to take
Once daily per label · as needed for symptoms (HealthHub)
Take with
With or without food · with water · food may slow onset
Pros & cons
Pros
- Once-a-day dose — label max one 10 mg tablet in 24 h
- Zyrtec-r is general sale list — sold beyond pharmacies
- NHS: unlikely to harm if taken long term
Cons
- Sleepy/tired in more than 1 in 10 people (NHS)
- 'non-drowsy' but driving care still advised
- Dry mouth, headache; alcohol adds to drowsiness
Sources
- MOH National Drug Formulary — ZYRTEC-R FILM-COATED TABLET 10 MG [SIN14890P] (HSA-registered product record + clinical info) · read 2026-08-27
what it says
“CETIRIZINE 2HCL - 10 MG … TABLET, FILM COATED … GENERAL SALE LIST … GLAXOSMITHKLINE PTE LTD … 1 tablet once daily … Half of the tablet as a starting dose may be used if this leads to satisfactory control … Do not take more than one 10 mg tablet in 24 hours … Don't take Zyrtec-R: … If you have severe kidney disease (severe impairment of kidney function with estimated GFR less than 15 ml/min). If you use other anti-allergy medicines. If you are breastfeeding … If you think any of these applies to you, don't take Zyrtec-R until you have checked with your doctor or pharmacist”
- MOH National Drug Formulary — ZYRTEC TABLET 10 MG [SIN03022P] (HSA-registered product record) · read 2026-08-27
what it says
“CETIRIZINE 2HCL - 10 MG … TABLET, FILM COATED … PHARMACY ONLY MEDICINES … GLAXOSMITHKLINE PTE LTD … nasal and ocular symptoms of seasonal and perennial allergic rhinitis … symptoms of chronic idiopathic urticaria … 10 mg once daily [1 tablet, 20 drops, or 10 ml oral solution] … Hypersensitivity to any of the constituents of the formulation, to hydroxyzine or to any piperazine derivatives”
- MOH National Drug Formulary — SIMTEC TABLET 10MG (OTC) [SIN15142P] · read 2026-08-27
what it says
“CETIRIZINE HCL - 10 MG … TABLET, FILM COATED … GENERAL SALE LIST … DUOPHARMA (SINGAPORE) PTE LTD”
- HSA — List of reclassified medicines (forensic class definitions: POM / P / GSL) · read 2026-08-27
what it says
“GSL: A therapeutic product that can be obtained from any retailer … P: A therapeutic product that can be obtained from a pharmacist at a retail pharmacy without a prescription”
- HealthHub (MOH Singapore) — Cetirizine medication page (updated 3 Jun 2026) · read 2026-08-27
what it says
“Cetirizine belongs to a group of medicines known as antihistamines … Runny nose (due to a cold, flu or allergies) … Itch in the eyes, nose or skin … with or without food. However, food may slow down the absorption leading to a slower time to take effect … when necessary to relieve your symptoms … Liver or kidney problems … Seizures … Enlarged prostate gland … Difficulty urinating … Affect alertness (drowsiness and tiredness) … Headache … Dry mouth, skin and eyes … Avoid driving, operating machinery or other activities which require concentration while on this medication … Taking this medication with alcohol may worsen the drowsy side effect. Avoid alcohol while on this medication … Zyrtec, Adezio, Agelmin, Allercet, Allertec, Alzytec, Atrizin, Ceritec, Sunizine, and Terizin”
- NHS — How and when to take cetirizine (reviewed 18 Feb 2025) · read 2026-08-27
what it says
“The usual dose for adults and children aged 12 years old and over is 10mg once a day … You can take cetirizine with or without food, but always take the tablets with a drink of water, milk or squash … Cetirizine is generally very safe. Taking an extra dose is unlikely to harm you or your child”
- NHS — Who can and cannot take cetirizine (reviewed 18 Feb 2025) · read 2026-08-27
what it says
“have kidney failure … have epilepsy or another health problem that means you're at risk of having seizures or fits … have a condition that means you have difficulty peeing … are due to have an allergy test – taking cetirizine may affect the results”
- NHS — Side effects of cetirizine (reviewed 18 Feb 2025) · read 2026-08-27
what it says
“feeling sleepy and tired. This happens in more than 1 in 10 people … Do not drive, cycle or use tools or machines if you feel dizzy or a bit shaky … Call your doctor or call 111 straight away if you're bruising more easily than normal or have bleeding that takes longer to stop”
- NHS — About cetirizine (reviewed 17 Feb 2025) · read 2026-08-27
what it says
“cetirizine is classed as a non-drowsy antihistamine … some people still find it makes them feel quite sleepy. Do not drive or ride a bike if it makes you sleepy … headaches, dry mouth, feeling sick, feeling dizzy and diarrhoea … is available on prescription, and to buy from pharmacies and shops”
- NHS — Common questions about cetirizine (reviewed 18 Feb 2025) · read 2026-08-27
what it says
“You should start to feel better within an hour after taking cetirizine … Cetirizine is unlikely to do you any harm if you take it for a long time … It's best not to drink alcohol while you're taking cetirizine as it can make you feel sleepy … You can eat and drink normally while taking cetirizine”
- NHS — Taking cetirizine with other medicines and herbal supplements (reviewed 18 Feb 2025) · read 2026-08-27
what it says
“Check with your pharmacist or doctor if you're taking any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee … There might be a problem taking some herbal remedies and supplements alongside cetirizine, especially ones that cause sleepiness, a dry mouth, or make it difficult to pee”
- DailyMed / FDA — ZYRTEC ALLERGY (cetirizine HCl 10 mg) film-coated tablet, OTC Drug Facts (effective 10 Oct 2025) · read 2026-08-27
what it says
“Cetirizine HCl 10 mg … Antihistamine … runny nose … sneezing … itchy, watery eyes … itching of the nose or throat … Ask a doctor before use if you have liver or kidney disease … Ask a doctor or pharmacist before use if you are taking tranquilizers or sedatives … drowsiness may occur … avoid alcoholic drinks … alcohol, sedatives, and tranquilizers may increase drowsiness … be careful when driving a motor vehicle or operating machinery … if breast-feeding: not recommended … if pregnant: ask a health professional before use … adults and children 6 years and over: one 10 mg tablet once daily; do not take more than one 10 mg tablet in 24 hours … adults 65 years and over: ask a doctor”
- FDA — ZYRTEC (cetirizine hydrochloride) tablets and syrup, prescribing information (2002 label, NDA 19-835 / 20-346) · read 2026-08-27
what it says
“No clinically significant drug interactions have been found with theophylline at a low dose, azithromycin, pseudoephedrine, ketoconazole, or erythromycin … There was a small decrease in the clearance of cetirizine caused by a 400-mg dose of theophylline … Concurrent use of ZYRTEC with alcohol or other CNS depressants should be avoided because additional reductions in alertness and additional impairment of CNS performance may occur … given as a single daily dose, with or without food … The incidence of somnolence associated with ZYRTEC was dose related, 6% in placebo, 11% at 5 mg and 14% at 10 mg”
Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.