{"ok":true,"entry":{"slug":"zopiclone","kind":"medication","name":"zopiclone","aliases":["Imovane"],"brands_sg":["Imovane","Apo-Zopiclone","Zopiclone (Pharmline)"],"class":"non-benzodiazepine hypnotic","tags":["mental-health"],"use_for":"prescribed short-term for insomnia","use_after":"nhs: just before bed · starts working in 30–60 minutes","use_duration":null,"take_with":"healthhub: with or without food · nhs: no alcohol","pros":["nhs: a z-drug hypnotic for short-term insomnia","sg imovane label: one 7.5 mg tablet, not to be exceeded","healthhub: most side effects improve with time"],"cons":["nhs: next-day sleepiness — no driving for 12 hours","healthhub: habit-forming; withdrawal if stopped fast","nhs: sleepwalking and other complex sleep behaviours"],"dose_note":"the singapore imovane 7.5 mg package insert on the national drug formulary states “adults: the recommended dose is one 7.5 mg IMOVANE tablet by oral route. this dose should not be exceeded”, and that it “should be taken in a single intake and not be re-administered during the same night”. the same insert puts a starting dose of 3.75 mg (half a tablet) in the elderly, in impaired liver function, in chronic respiratory insufficiency and in renal insufficiency, and says treatment “should not exceed four weeks including the period of tapering off”. all three zopiclone products on the sg register are 7.5 mg tablets. in singapore this is prescription-only and the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["myasthenia gravis, respiratory failure or severe sleep apnoea — sg label: contraindicated","severe liver impairment — sg label: contraindicated; 3.75 mg start if impaired","past addiction to alcohol, drugs or prescription medicine, especially opioids (nhs)","complex sleep behaviours on zopiclone before — sg label: contraindicated"],"clashes":[{"src":["nhs_zopi_alcohol","hh_zopi_avoid"],"food":true,"note":"nhs: can cause breathing problems and make it very difficult to wake up; healthhub: excessive sleepiness","with":"alcohol"},{"src":["nhs_zopi_inter"],"note":"nhs: listed among medicines that may not mix well with zopiclone","with":"opioid painkillers (codeine, morphine, oxycodone)"},{"src":["nhs_zopi_inter"],"note":"nhs: listed among medicines that may not mix well with zopiclone","with":"other sleep or anxiety medicines, antipsychotics, antidepressants"},{"src":["nhs_zopi_inter"],"note":"nhs: listed among medicines that may not mix well with zopiclone","with":"sedating antihistamines (chlorphenamine, promethazine)"},{"src":["nhs_zopi_inter"],"note":"nhs: listed among medicines that may not mix well with zopiclone","with":"clarithromycin, erythromycin and antifungals"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally, not re-fetched)","quote":"All 3 registered zopiclone products carry Forensicclassification 'Prescription Only' — SIN05047P IMOVANE TABLET 7.5 mg · SIN09355P APO-ZOPICLONE TABLET 7.5 mg · SIN11416P ZOPICLONE TABLET 7.5 mg (ATC N05CF01)","accessed":"2026-08-27"},{"id":"ndf_imovane_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin05047p/","label":"Singapore National Drug Formulary — IMOVANE TABLET 7.5 MG [SIN05047P], Product Info and Indication","quote":"Forensic Classification PRESCRIPTION ONLY MEDICINES … IMOVANE is intended for treatment of short-term treatment of insomnia in adults (including difficulties with falling asleep, nocturnal awakening, and early wakening).","accessed":"2026-08-27"},{"id":"ndf_imovane_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin05047p/","label":"Singapore National Drug Formulary — IMOVANE [SIN05047P], Dosage and method of administration","quote":"Adults: the recommended dose is one 7.5 mg IMOVANE tablet by oral route. This dose should not be exceeded … should be taken in a single intake and not be re-administered during the same night.","accessed":"2026-08-27"},{"id":"ndf_imovane_dur","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin05047p/","label":"Singapore National Drug Formulary — IMOVANE [SIN05047P], Treatment duration and special populations","quote":"Treatment should be as short as possible and should not exceed four weeks including the period of tapering off … In elderly and in patients with impaired liver function or chronic respiratory insufficiency: a starting dose of 3.75 mg","accessed":"2026-08-27"},{"id":"ndf_imovane_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin05047p/","label":"Singapore National Drug Formulary — IMOVANE [SIN05047P], Contraindications","quote":"IMOVANE is contraindicated in patients: With myasthenia gravis … With respiratory failure … With severe sleep apnea syndrome … With severe hepatic insufficiency … Who have previously experienced complex sleep behaviors after taking IMOVANE","accessed":"2026-08-27"},{"id":"nhs_zopi_about","url":"https://www.nhs.uk/medicines/zopiclone/","label":"NHS — Zopiclone: what zopiclone is for, how to take zopiclone","quote":"Zopiclone is used as a short-term treatment for sleeping problems (insomnia) … It's a type of sleeping pill that's sometimes known as a Z-drug. These are a kind of medicine called a hypnotic","accessed":"2026-08-27"},{"id":"nhs_zopi_how","url":"https://www.nhs.uk/medicines/zopiclone/","label":"NHS — Zopiclone: how to take zopiclone","quote":"Zopiclone comes as tablets you swallow once a day, before you go to bed. It takes around 30 to 60 minutes to start working … Treatment with zopiclone usually lasts from a few days to a few weeks.","accessed":"2026-08-27"},{"id":"nhs_zopi_se","url":"https://www.nhs.uk/medicines/zopiclone/","label":"NHS — Zopiclone: common side effects","quote":"Common side effects of zopiclone include: dry mouth … a bitter or metallic taste … feeling tired, sleepy, dazed or less alert the next day. Do not drive, ride a bike or use machinery for 12 hours after taking zopiclone.","accessed":"2026-08-27"},{"id":"nhs_zopi_serious","url":"https://www.nhs.uk/medicines/zopiclone/","label":"NHS — Zopiclone: serious side effects","quote":"Possible serious side effects of zopiclone include: difficulty breathing … sleepwalking, or doing things while not fully awake, like eating, talking on the phone or driving … hallucinations … thoughts of suicide or harming yourself","accessed":"2026-08-27"},{"id":"nhs_zopi_who","url":"https://www.nhs.uk/medicines/zopiclone/","label":"NHS — Zopiclone: who can and cannot take zopiclone","quote":"it may not be suitable if: … you have sleep apnoea or breathing problems … you have liver problems … you've been addicted to alcohol, drugs or prescription medicine before, especially opioids","accessed":"2026-08-27"},{"id":"nhs_zopi_inter","url":"https://www.nhs.uk/medicines/zopiclone/","label":"NHS — Zopiclone: taking zopiclone with other medicines, food and drink","quote":"These include some: other medicines for sleep or anxiety problems … opioid painkillers like codeine, morphine or oxycodone … antipsychotics … antidepressants … sedating antihistamines … antibiotics, such as clarithromycin or erythromycin","accessed":"2026-08-27"},{"id":"nhs_zopi_alcohol","url":"https://www.nhs.uk/medicines/zopiclone/","label":"NHS — Zopiclone: food, drink and alcohol with zopiclone","quote":"Do not drink alcohol while taking zopiclone. Alcohol can increase the effects of the medicine, which can cause breathing problems and make it very difficult to wake up.","accessed":"2026-08-27"},{"id":"hh_zopi_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/zopiclone","label":"HealthHub (Pharmaceutical Society of Singapore) — Zopiclone: how should I take or use this medication","quote":"This medication may be taken with or without food. This medication should be taken just before going to bed when you are ready to sleep. You should obtain this medication from the same doctor or clinic whenever possible.","accessed":"2026-08-27"},{"id":"hh_zopi_depend","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/zopiclone","label":"HealthHub — Zopiclone: precautions (dependence and withdrawal)","quote":"This medication may be habit-forming when taken excessively or for a prolonged duration … do not stop taking it abruptly as it may lead to withdrawal symptoms such as increased sweating, increased heart rate, tremors","accessed":"2026-08-27"},{"id":"hh_zopi_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/zopiclone","label":"HealthHub — Zopiclone: common side effects","quote":"Most of the side effects listed here will improve with time. Speak with your doctor if any of them continues, worsens or affects your daily life.","accessed":"2026-08-27"},{"id":"hh_zopi_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/zopiclone","label":"HealthHub — Zopiclone: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking Zopiclone as it can cause excessive sleepiness.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:34.039038+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}