{"ok":true,"entry":{"slug":"ziziphus","kind":"supplement","name":"ziziphus seed","aliases":["Ziziphus jujuba","suan zao ren","sour jujube seed"],"brands_sg":[],"class":"botanical","tags":["sleep"],"use_for":"short-term sleep quality in insomnia trials","use_after":null,"use_duration":"sleep outcomes were measured at about 4 weeks","take_with":null,"pros":["beat placebo on sleep quality (smd -0.58)","insomnia severity fell 2.68 points at 4 weeks","no rise in major adverse events reported"],"cons":["long-term effects were mixed across trials","9 small trials, study quality varied","gains are patient-reported, not objective"],"dose_note":"the review pooled 9 randomised trials of suanzaoren (ziziphi spinosae semen); its abstract does not state a common daily dose","dosage":{"ul":null,"unit":null,"fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["not listed in hsa's annexes — that is not a safety clearance","long-term benefit and harm are still untested"],"clashes":[],"sources":[{"id":"suanzaoren2023","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10084578/","label":"Suanzaoren (Ziziphi Spinosae Semen) for sleep quality: systematic review and meta-analysis (Integr Cancer Ther 2023)","quote":"Compared with placebo, Suanzaoren led to significant subjective sleep quality improvements … (standard mean difference -0.58, 95% CI -1.04, -0.11) … significant decrease in insomnia severity (mean difference -2.68 points) at 4 weeks","accessed":"2026-08-27"},{"id":"suanzaoren2023_limits","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10084578/","label":"Suanzaoren for sleep quality — trial count, long-term effects and quality (Integr Cancer Ther 2023)","quote":"9 trials … The long-term effects of Suanzaoren were mixed among trials. Suanzaoren did not increase the incidence of major adverse events … Due to the small sample size and variable study quality","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025, GL-CHPB-1-012)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026, GL-CHPB-3-001 Rev. 020), Tables 4–5","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:34.039038+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}