{"ok":true,"entry":{"slug":"uva-ursi","kind":"supplement","name":"uva ursi","aliases":["Arctostaphylos uva-ursi","bearberry"],"brands_sg":["Nature's Way","Solaray","Nutricost","Nature's Answer","Eclectic Herb"],"class":"botanical","tags":["womens-health"],"use_for":"studied against an antibiotic for urinary symptoms","use_after":null,"use_duration":"the 2021 german primary-care trial dosed it for 5 days","take_with":null,"pros":["gagyor 2021: 63.6% fewer antibiotic courses","arbutin, its main compound, is anti-adhesive in vitro","german women report it most for urinary complaints"],"cons":["gagyor 2021: higher symptom burden than fosfomycin","gagyor 2021: more safety concerns than the antibiotic","urinary infections can worsen when treatment is delayed"],"dose_note":"the 2021 german primary-care trial gave 105 mg tablets, two tablets three times a day for 5 days; singapore listings run 350 mg to 460 mg of leaf per capsule, and one liquid extract at 1,000 mg","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["symptoms that persist or worsen — a doctor should see them","hydroquinone is one of bearberry's main constituents","the only trial in these sources ran 5 days, not longer","singapore does not allow urinary-infection claims on supplements"],"clashes":[],"sources":[{"id":"gagyor2021","url":"https://europepmc.org/article/MED/34111592","label":"Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: a randomized controlled trial (Gagyor et al., Clin Microbiol Infect 2021)","quote":"receiving either UU 105 mg 3 × 2 tablets for 5 days (intervention) or fosfomycin a 3-g single dose … The number of antibiotic courses was 63.6% lower … initial treatment with UU reduced antibiotic use but led to a higher symptom burden and more safety concerns than fosfomycin.","accessed":"2026-08-27"},{"id":"uti_plants2025","url":"https://europepmc.org/article/PMC/PMC12384774","label":"Plant Extracts and Natural Compounds for the Treatment of Urinary Tract Infections in Women (Curr Issues Mol Biol 2025)","quote":"A-type proanthocyanidins in cranberry and arbutin in bearberry are key bioactive compounds that exhibit potent anti-adhesive and biofilm-disrupting properties, offering promising adjunctive strategies for preventing recurrent urinary tract infections.","accessed":"2026-08-27"},{"id":"drebka2026","url":"https://europepmc.org/article/PMC/PMC13254121","label":"Trends and Patterns for the Use of Herbal Medicinal Products for Gynaecological Ailments (Drebka et al., Phytother Res 2026; PhytoVIS real-world data, n=1658)","quote":"Various herbal drugs were applied for uncomplicated urinary tract infections (uUTIs), but mainly Arctostaphylos uva-ursi (L.) Spreng. Regarding the pharmaceutical form, herbal teas were preferred for the treatment of uUTIs","accessed":"2026-08-27"},{"id":"cochrane_uti2024","url":"https://europepmc.org/article/PMC/PMC11656515","label":"Non-steroidal anti-inflammatory drugs for treating symptomatic uncomplicated urinary tract infections in non-pregnant adult women (Cochrane Database Syst Rev 2024) — background","quote":"Although usually self-remitting, 74% of women contacting a health professional are prescribed an antibiotic, and in rare instances, they may progress to more severe infections.","accessed":"2026-08-27"},{"id":"szwajgier2024","url":"https://europepmc.org/article/PMC/PMC11678513","label":"Effect of the Type of Herbal Preparations on the Bioaccessibility of Bearberry (Arctostaphylos uva-ursi) Phytochemicals (Molecules 2024)","quote":"The content of the main compounds, i.e., arbutin, hydroquinone, hyperoside, pentagalloylglucose, and picein … The bioaccessibility of arbutin, i.e., the main compound in bearberry, was high, in most cases exceeding 95%","accessed":"2026-08-27"},{"id":"hsa_annex","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, Version 1 (Oct 2025), Annex A (72 rows) and Annex B (4 rows: caffeine, green tea extract, St John's wort, L-tryptophan) — read from the cached PDF text on disk","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_table6","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines, Rev. No. 020 (January 2026), Table 6: diseases/conditions not allowed for health supplements","quote":"HS must not be labelled, advertised or promoted for any specific medicinal purpose, i.e. treatment or prevention, implied or otherwise, of any disease or disorder, including its related conditions.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/uva-ursi","label":"iHerb Singapore — Uva Ursi category (default order, 1 - 8 of 8 results)","quote":"Nature's Way, Uva-Ursi Leaves (370 mg per Capsule) … Solaray, True Herbs, Uva Ursi, 460 mg … Nutricost, Women, Cranberry Extract … Nature's Answer, Uva Ursi Extract, Low Alcohol, 1,000 mg … Nutricost, Uva Ursi (450 mg per Capsule) … Eclectic Herb, Uva Ursi, 350 mg","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:33.302383+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}