{"ok":true,"entry":{"slug":"tretinoin","kind":"medication","name":"tretinoin","aliases":["Retin-A","all-trans retinoic acid"],"brands_sg":["Retacnyl","Retrieve","Tretinon","Tri-Luma","Vesanoid"],"class":"topical retinoid","tags":["skin"],"use_for":"us label: acne vulgaris, applied to the skin","use_after":"us label: once a day, before retiring","use_duration":null,"take_with":"us label: kept away from eyes, mouth and mucous membranes","pros":["us label: indicated for acne vulgaris on the skin","register: three tretinoin creams registered in sg","one nightly application is the whole labelled routine"],"cons":["label: redness, peeling, blistering and crusting","label: sun and sunlamp sensitivity rises on it","sg keeps every tretinoin cream prescription-only"],"dose_note":"no singapore dosing text was read: the national drug formulary pages for the sg creams (retacnyl sin08095p, retrieve sin12368p) carry product details but no indication or dosing section. the us label for tretinoin cream and gel states “Tretinoin Cream or Tretinoin Gel should be applied once a day, before retiring, to the skin where acne lesions appear, using enough to cover the entire affected area lightly”, and the retin-a micro label adds “once daily in the evening. Do not apply more than a thin layer” — once a day is the labelled ceiling for the creams, and the same label says frequency may be reduced when skin cannot tolerate it. separately, healthhub's singapore tretinoin leaflet is about the 10 mg oral capsule (vesanoid) used in hospital haematology, not about the creams.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["sunburn or heavy sun exposure — the label asks for particular caution","sensitivity or chemical irritation — label: the medication is discontinued","pregnancy — the sg-registered oral capsule needs two forms of birth control (healthhub)","eyes, mouth, nose creases and mucous membranes — label: kept away from these"],"clashes":[{"src":["fda_tret_di"],"note":"us label: used with caution because of possible interaction with tretinoin","with":"medicated or abrasive soaps, cleansers and drying cosmetics"},{"src":["fda_tret_di"],"note":"us label: particular caution; skin is ‘rested’ until their effects subside","with":"sulfur, resorcinol or salicylic acid preparations"},{"src":["fda_tret_prec"],"note":"us label: exposure should be minimized; sensitivity to sunlight is heightened","with":"sunlight and sunlamps"},{"src":["hh_tret_avoid"],"note":"healthhub, for the oral capsule: it may increase the risk of side effects","with":"vitamin a supplements (oral tretinoin)"},{"src":["hh_tret_avoid"],"note":"healthhub, for the oral capsule: risk of raised pressure in the head","with":"tetracycline antibiotics such as doxycycline (oral tretinoin)"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084); cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 6 tretinoin rows","quote":"RETACNYL 0.025 CREAM SIN08095P · RETACNYL 0.05 CREAM SIN08098P · RETRIEVE CREAM 0.05% SIN12368P · TRETINON CREAM 0.05% SIN16390P · TRI-LUMA CREAM SIN12607P · VESANOID CAPSULE 10 mg SIN08057P — all 6 rows “Prescription Only”","accessed":"2026-08-27"},{"id":"fda_tret_ind","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22tretinoin%22+AND+openfda.route:%22TOPICAL%22&limit=5","label":"US label for tretinoin cream (Bryant Ranch Prepack, effective 2025-10-21) via openFDA drug/label.json, Indications and Usage","quote":"Tretinoin is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established.","accessed":"2026-08-27"},{"id":"fda_tret_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22tretinoin%22+AND+openfda.route:%22TOPICAL%22&limit=5","label":"US label for tretinoin cream/gel via openFDA drug/label.json, Dosage and Administration","quote":"Tretinoin Cream or Tretinoin Gel should be applied once a day, before retiring, to the skin where acne lesions appear, using enough to cover the entire affected area lightly.","accessed":"2026-08-27"},{"id":"fda_tret_micro","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22tretinoin%22+AND+openfda.route:%22TOPICAL%22&limit=5","label":"US label for RETIN-A MICRO (Bausch Health, effective 2025-09-01) via openFDA drug/label.json, Dosage and Administration","quote":"Apply a thin layer of RETIN-A MICRO (0.04%, 0.06%, 0.08%, or 0.1%) to skin where acne lesions appear (cover the entire affected area), once daily in the evening. Do not apply more than a thin layer","accessed":"2026-08-27"},{"id":"fda_tret_di","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22tretinoin%22+AND+openfda.route:%22TOPICAL%22&limit=5","label":"US label for tretinoin cream via openFDA drug/label.json, Drug Interactions","quote":"Concomitant topical medication, medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect … should be used with caution … Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid","accessed":"2026-08-27"},{"id":"fda_tret_prec","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22tretinoin%22+AND+openfda.route:%22TOPICAL%22&limit=5","label":"US label for tretinoin cream via openFDA drug/label.json, Precautions","quote":"Exposure to sunlight, including sunlamps, should be minimized during the use of tretinoin … Tretinoin acne treatment should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes.","accessed":"2026-08-27"},{"id":"fda_tret_ae","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22tretinoin%22+AND+openfda.route:%22TOPICAL%22&limit=5","label":"US label for tretinoin cream via openFDA drug/label.json, Adverse Reactions","quote":"The skin of certain sensitive individuals may become excessively red, edematous, blistered, or crusted … Temporary hyper- or hypopigmentation has been reported with repeated application of tretinoin.","accessed":"2026-08-27"},{"id":"ndf_tret_retrieve","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12368p/","label":"Singapore National Drug Formulary — RETRIEVE CREAM 0.05% W/W [SIN12368P] (product details only; the page carries no Indication or Dosing section)","quote":"RETRIEVE CREAM 0.05% W/W [SIN12368P] … Active Ingredient and Strength TRETINOIN - 0.5 MG/G … Dosage Form CREAM … Manufacturer and Country MILPHARMA PTY LTD - AUSTRALIA","accessed":"2026-08-27"},{"id":"hh_tret_oral","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/tretinoin","label":"HealthHub (Pharmaceutical Society of Singapore / MOH) — Tretinoin (the oral capsule leaflet)","quote":"Tretinoin, also known as All-Trans-Retinoic acid (ATRA) … This medicine should be taken after food. Swallow the capsules whole … Use two forms of reliable birth control during and for at least one month after treatment","accessed":"2026-08-27"},{"id":"hh_tret_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/tretinoin","label":"HealthHub — Tretinoin: what food or medication should I avoid (oral capsule)","quote":"Do not take Vitamin A supplements while you are on tretinoin as this may increase the risk of side effects … Do not take this medication if you are currently taking any tetracycline class of antibiotics such as doxycycline","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:33.302383+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}