{"ok":true,"entry":{"slug":"tremella","kind":"supplement","name":"tremella","aliases":["Tremella fuciformis","snow fungus","white fungus","bai mu er"],"brands_sg":[],"class":"mushroom","tags":["general"],"use_for":"limited human evidence — skin data is in cell culture","use_after":null,"use_duration":null,"take_with":null,"pros":["long history as food and medicine in asia","used in dermocosmetics for moisturising claims","at 500 µg/ml it raised collagen in skin cells"],"cons":["that collagen result is cell culture, not people","the lower 200 µg/ml dose did nothing for collagen","authors say reproducibility still needs confirming"],"dose_note":"no oral dose is established; the skin findings quoted here come from human dermal fibroblasts treated with 200 or 500 µg/ml of a commercial tremella extract in culture, not from people taking it, and the polysaccharide review still describes tremella polysaccharides as candidates for functional-food development","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["the skin evidence sourced here is cultured human fibroblasts, not skin on a person, and the authors call for confirmation","the polysaccharide review frames tremella as a promising candidate for development rather than an established ingredient","no oral human trial was found, so nothing here supports a swallowed dose — absence of evidence is not evidence of safety","not listed in hsa's annex a/b — hsa says that list is not exhaustive"],"clashes":[],"sources":[{"id":"tfe2026_context","url":"https://europepmc.org/article/MED/42451721","label":"Tremella fuciformis Extract Evokes Similar Effect as Hyaluronic Acid on Wound Healing but Through Different Mechanisms in Human Dermal Fibroblasts (Molecules 2026) — context","quote":"Tremella fuciformis extract (TFE) is used in dermocosmetic formulations due to its moisturising, antioxidant, and skin-supportive properties.","accessed":"2026-08-27"},{"id":"tfe2026_design","url":"https://europepmc.org/article/MED/42451721","label":"Tremella fuciformis extract fibroblast study, Molecules 2026 — what was tested","quote":"The cells were treated with TFE at concentrations of either 200 µg/mL or 500 µg/mL, or with HA at a concentration of 500 µg/mL.","accessed":"2026-08-27"},{"id":"tfe2026_result","url":"https://europepmc.org/article/MED/42451721","label":"Tremella fuciformis extract fibroblast study, Molecules 2026 — results","quote":"The synthesis of collagen was found to be considerably elevated by both HA and TFE500, with no such effect observed in the presence of TFE200 … The mean scratch-wound closure was found to be highest for TFE500","accessed":"2026-08-27"},{"id":"tfe2026_limits","url":"https://europepmc.org/article/MED/42451721","label":"Tremella fuciformis extract fibroblast study, Molecules 2026 — limitation stated by the authors","quote":"Further studies are required to confirm biological reproducibility and the mechanism.","accessed":"2026-08-27"},{"id":"tfp2025_review","url":"https://europepmc.org/article/PMC/PMC12672291","label":"Recent advances in polysaccharides from Tremella fuciformis: isolation, structures, bioactivities and application (Front Nutr 2025) — traditional use and reported activities","quote":"Tremella fuciformis, commonly known as snow fungus, is a traditional edible and medicinal fungus widely used in Asian countries for centuries … TFPs exhibit a broad spectrum of health-promoting effects, including microbial homeostasis, immuno-modulatory, antioxidant","accessed":"2026-08-27"},{"id":"tfp2025_gap","url":"https://europepmc.org/article/PMC/PMC12672291","label":"Tremella fuciformis polysaccharide review, Front Nutr 2025 — status of the evidence","quote":"The findings suggest that TFPs are promising natural bioactive compounds with potential applications in disease prevention and treatment, and they represent valuable candidates for the development of functional foods and therapeutic agents.","accessed":"2026-08-27"},{"id":"hsa_pr_notlisted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A/B — searched, no row for this ingredient","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/mushrooms","label":"iHerb Singapore — no Tremella category exists (sg.iherb.com/c/tremella and /c/tremella-mushroom both return HTTP 404); the general Mushrooms category was read instead and its listing showed no tremella or snow fungus product, so brands_sg is left empty","quote":"1 - 48 of 475 results","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:33.302383+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}