{"ok":true,"entry":{"slug":"trazodone","kind":"medication","name":"trazodone","aliases":["Trittico"],"brands_sg":["Trittico"],"class":"serotonin antagonist antidepressant","tags":["mental-health"],"use_for":"prescribed for depression; also used for poor sleep","use_after":"nhs: once or twice a day; often at bedtime if drowsy","use_duration":null,"take_with":"food · nhs: tablets swallowed whole with water","pros":["nhs: thought to raise serotonin levels linked to mood","healthhub: also prescribed for difficulty sleeping","nhs: can be used in pregnancy if a doctor decides"],"cons":["nhs: sleepiness, dizziness, headaches, dry mouth","fda: boxed warning on suicidal thoughts, under 25s","healthhub: rare priapism — erection over four hours"],"dose_note":"the us fda label for trazodone hydrochloride tablets states 'The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses' and that inpatients 'may be given up to but not in excess of 600 mg/day in divided doses', from a starting dose of 150 mg/day in divided doses. the one sg-registered product is trittico 50 mg tablets. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["a history of bipolar disorder or mania (nhs)","heart, kidney or liver problems, or epilepsy (nhs)","past thoughts of self-harm — nhs lists this","under 25 — fda: higher risk of suicidal thoughts"],"clashes":[{"src":["fda_traz_ci"],"note":"fda: contraindicated, and within 14 days of stopping an maoi, because of serotonin syndrome risk","with":"maois (linezolid, moclobemide, selegiline)"},{"src":["nhs_traz_mix"],"note":"nhs lists amitriptyline, fluoxetine and moclobemide among medicines that may not mix well","with":"other antidepressants"},{"src":["nhs_traz_mix"],"note":"nhs: this herbal supplement is not to be used with trazodone","with":"st john's wort"},{"src":["nhs_traz_mix","hh_traz_food"],"food":true,"note":"nhs lists sedatives among poor mixes; healthhub: alcohol can cause excessive sleepiness","with":"sleeping pills, sedatives and alcohol"},{"src":["fda_traz_di","nhs_traz_mix"],"note":"fda: monitor prothrombin time, digoxin and phenytoin levels; nhs also lists warfarin and epilepsy medicines","with":"warfarin, digoxin, phenytoin, carbamazepine"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"The register carries one trazodone product: SIN10777P TRITTICO TABLETS 50 mg, Activeingredients 'TRAZODONE HCl', Forensicclassification 'Prescription Only', ATC N06AX05.","accessed":"2026-08-27"},{"id":"nhs_traz_about","url":"https://www.nhs.uk/medicines/trazodone/","label":"NHS Medicines A-Z — Trazodone: what trazodone is for","quote":"Trazodone is an antidepressant medicine used to treat depression and anxiety. It's only available with a prescription … It's thought to work by increasing the levels of chemicals in your brain linked to mood, such as serotonin.","accessed":"2026-08-27"},{"id":"nhs_traz_howto","url":"https://www.nhs.uk/medicines/trazodone/","label":"NHS Medicines A-Z — Trazodone: how to take trazodone","quote":"swallow tablets or capsules whole, with water, once or twice a day; take it with, or just after food, to reduce the risk of side effects; take it at bedtime if you're having trouble sleeping","accessed":"2026-08-27"},{"id":"nhs_traz_side","url":"https://www.nhs.uk/medicines/trazodone/","label":"NHS Medicines A-Z — Trazodone: side effects","quote":"Common side effects of trazodone include: feeling sleepy, dizzy or tired; headaches; feeling sick (nausea); difficulty pooing (constipation); muscle pain; a dry mouth","accessed":"2026-08-27"},{"id":"nhs_traz_who","url":"https://www.nhs.uk/medicines/trazodone/","label":"NHS Medicines A-Z — Trazodone: who can and cannot take it","quote":"it may not be suitable if you have: ever had an allergic reaction … ever had thoughts of self-harming or ending your life; a history of bipolar disorder; heart, kidney or liver problems; epilepsy; an overactive thyroid","accessed":"2026-08-27"},{"id":"nhs_traz_preg","url":"https://www.nhs.uk/medicines/trazodone/","label":"NHS Medicines A-Z — Trazodone: pregnancy","quote":"Trazodone can be used during pregnancy if needed. Your doctor will talk to you about the risks and benefits … your doctor will prescribe the lowest possible effective dose.","accessed":"2026-08-27"},{"id":"nhs_traz_mix","url":"https://www.nhs.uk/medicines/trazodone/","label":"NHS Medicines A-Z — Trazodone: taking it with other medicines","quote":"other antidepressants, such as amitriptyline, fluoxetine or moclobemide; antifungal medicines … epilepsy medicines, such as carbamazepine or phenytoin; sleeping pills, tranquilisers or other sedatives … warfarin … Do not use the herbal supplement St John's wort","accessed":"2026-08-27"},{"id":"hh_traz_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/trazodone","label":"HealthHub (Pharmaceutical Society of Singapore) — Trazodone: what is this medication for","quote":"Trazodone belongs to a class of medications known as Serotonin Antagonist and Reuptake Inhibitor (SARI). It is used to treat symptoms of depression … Your doctor may also prescribe Trazodone if you have difficulty sleeping","accessed":"2026-08-27"},{"id":"hh_traz_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/trazodone","label":"HealthHub — Trazodone: how should I take this medication","quote":"Trazodone should be taken with or after food. Take your medication according to the instructions stated on the medication label.","accessed":"2026-08-27"},{"id":"hh_traz_serious","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/trazodone","label":"HealthHub — Trazodone: rare but serious side effects","quote":"Rarely, this medication may cause: Seizures (fits) … Painful erection of the penis (male sexual organ) lasting more than four hours (also known as priapism) … signs and symptoms of serotonin syndrome","accessed":"2026-08-27"},{"id":"hh_traz_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/trazodone","label":"HealthHub — Trazodone: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking Trazodone as it can worsen the symptoms of your depression and cause excessive sleepiness.","accessed":"2026-08-27"},{"id":"fda_traz_ind","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22trazodone%22&limit=3","label":"US FDA label — trazodone hydrochloride tablets, section 1 Indications and Usage, via openFDA drug/label.json","quote":"Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder (MDD) in adults.","accessed":"2026-08-27"},{"id":"fda_traz_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22trazodone%22&limit=3","label":"US FDA label — trazodone hydrochloride tablets, section 2 Dosage and Administration, via openFDA drug/label.json","quote":"The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses. Inpatients … may be given up to but not in excess of 600 mg/day in divided doses.","accessed":"2026-08-27"},{"id":"fda_traz_boxed","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22trazodone%22&limit=3","label":"US FDA label — trazodone hydrochloride tablets, boxed warning, via openFDA drug/label.json","quote":"Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies … Trazodone is not approved for use in pediatric patients","accessed":"2026-08-27"},{"id":"fda_traz_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22trazodone%22&limit=3","label":"US FDA label — trazodone hydrochloride tablets, section 4 Contraindications, via openFDA drug/label.json","quote":"contraindicated in: Patients taking, or within 14 days of stopping, monoamine oxidase inhibitors (MAOIs), including MAOIs such as linezolid or intravenous methylene blue, because of an increased risk of serotonin syndrome","accessed":"2026-08-27"},{"id":"fda_traz_di","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22trazodone%22&limit=3","label":"US FDA label — trazodone hydrochloride tablets, section 7 Drug Interactions, via openFDA drug/label.json","quote":"CNS Depressants: Trazodone may enhance effects of alcohol, barbiturates, or other CNS depressants … Digoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels … Warfarin: Monitor for increased or decreased prothrombin time","accessed":"2026-08-27"},{"id":"fda_traz_start","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22trazodone%22&limit=3","label":"US FDA label — trazodone hydrochloride tablets, section 2.1 Dose Selection, via openFDA drug/label.json","quote":"An initial dose of 150 mg/day in divided doses is suggested … The dose may be increased by 50 mg/day every 3 to 4 days.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:33.302383+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}