{"ok":true,"entry":{"slug":"tranexamic-acid","kind":"medication","name":"tranexamic acid","aliases":["Transamin","Cyklokapron"],"brands_sg":["Cyklokapron","Tranexamic Acid Mevon","Xamilux","Haemostop","Medsamic"],"class":"antifibrinolytic","tags":["other"],"use_for":"prescribed to reduce heavy bleeding, e.g. heavy periods","use_after":"healthhub: for periods, not started before menses begin","use_duration":null,"take_with":"water · healthhub: with or without food","pros":["healthhub: slows the breakdown of blood clots","nhs: 500 mg tablets; usual dose 2–3, 3 times a day","nhs: usually taken about 4 days for heavy periods"],"cons":["fda: contraindicated with combined contraceptive pills","fda: clots and retinal vein or artery occlusion seen","healthhub: eyesight changes need urgent medical advice"],"dose_note":"the us label for tranexamic acid tablets (heavy menstrual bleeding) states '1,300 mg three times a day (3,900 mg/day) for a maximum of 5 days during monthly menstruation', with lower dosing when serum creatinine is raised. the nhs page for the uk 500 mg tablets describes 'the usual dose is 2 or 3 tablets, taken 3 times a day'. the sg register carries 500 mg tablets and 100 mg/ml injection. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["active clots, or a history or intrinsic risk of them — fda: contraindicated","kidney problems — fda: lower dosing; healthhub: tell your professional","eyesight or colour-vision changes — fda: use stopped, eyes examined","subarachnoid haemorrhage — fda: cerebral oedema and infarction reported"],"clashes":[{"src":["fda_txa_ci","fda_txa_di"],"note":"fda: contraindicated — both are prothrombotic, so the thrombotic risk may rise further","with":"combined hormonal contraceptives"},{"src":["fda_txa_di"],"note":"fda: may decrease the efficacy of both; tranexamic acid is stopped if tpa is needed","with":"tissue plasminogen activators"},{"src":["fda_txa_di"],"note":"fda: not recommended together because the risk of thrombosis may be increased","with":"factor ix complex or anti-inhibitor coagulant concentrates"},{"src":["fda_txa_di"],"note":"fda: not recommended in acute promyelocytic leukaemia because of the procoagulant effect","with":"all-trans retinoic acid (oral tretinoin)"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows; cached at /tmp/hsa_all.json and filtered locally, not re-fetched)","quote":"All 7 registered tranexamic acid products read Forensicclassification 'Prescription Only' — SIN02487P CYKLOKAPRON TABLET 500 mg · SIN17452P TRANEXAMIC ACID MEVON 500 MG · plus CYKLOKAPRON, XAMILUX, HAEMOSTOP, MEDSAMIC and TAFIXYL injections 100 mg/ml (B02AA02)","accessed":"2026-08-27"},{"id":"hh_txa_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/tranexamic-acid","label":"HealthHub (Pharmaceutical Society of Singapore) — Tranexamic acid: what is this medication for","quote":"Tranexamic acid is used to prevent or reduce excessive bleeding … known as an anti-fibrinolytic, which prevents blood clots from breaking down and hence, reduces the amount of blood lost.","accessed":"2026-08-27"},{"id":"hh_txa_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/tranexamic-acid","label":"HealthHub — Tranexamic acid: how should I take or use this medication","quote":"You may take this medication with or without food. If you are taking tranexamic acid for heavy menstrual bleeding, do not start taking the medicine until your menses have started.","accessed":"2026-08-27"},{"id":"hh_txa_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/tranexamic-acid","label":"HealthHub — Tranexamic acid: what precautions should I take","quote":"You have a history of or current medical conditions such as blood clots in your legs, lungs or anywhere else in your body, stroke, seizures (fits), or kidney problems.","accessed":"2026-08-27"},{"id":"hh_txa_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/tranexamic-acid","label":"HealthHub — Tranexamic acid: rare but serious side effects","quote":"Changes in eyesight e.g. blurred vision, changes in colour vision. Blood clot in the blood vessel (thrombosis) … you should stop your medication and see your healthcare professional immediately.","accessed":"2026-08-27"},{"id":"nhs_txa_dose","url":"https://www.nhs.uk/medicines/tranexamic-acid/how-and-when-to-take-tranexamic-acid/","label":"NHS — Tranexamic acid: how and when to take it (brand names: Cyklokapron, Evana Heavy Period Relief)","quote":"Tranexamic acid comes as 500mg tablets. For adults the usual dose is 2 or 3 tablets, taken 3 times a day … You'll usually take this medicine for 4 days for heavy periods","accessed":"2026-08-27"},{"id":"fda_txa_ind","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22TRANEXAMIC+ACID%22+AND+openfda.route:%22ORAL%22&limit=3","label":"US FDA label for tranexamic acid tablets (Nordic Pharma), Indications and Usage, via openFDA (effective 2025-09-29)","quote":"Tranexamic acid USP tablets are indicated for the treatment of cyclic heavy menstrual bleeding in females of reproductive potential … an antifibrinolytic","accessed":"2026-08-27"},{"id":"fda_txa_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22TRANEXAMIC+ACID%22+AND+openfda.route:%22ORAL%22&limit=3","label":"US FDA label for tranexamic acid tablets (Nordic Pharma), section 2 Dosage and Administration, via openFDA","quote":"1,300 mg three times a day (3,900 mg/day) for a maximum of 5 days during monthly menstruation … Renal impairment: Lower dosage is needed … if serum creatinine concentration (Cr) is higher than 1.4 mg/dL","accessed":"2026-08-27"},{"id":"fda_txa_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22TRANEXAMIC+ACID%22+AND+openfda.route:%22ORAL%22&limit=3","label":"US FDA label for tranexamic acid tablets (Nordic Pharma), section 4 Contraindications, via openFDA","quote":"Concomitant use of combined hormonal contraceptives … Active thromboembolic disease or a history or intrinsic risk of thrombosis or thromboembolism, including retinal vein or artery occlusion … Hypersensitivity to tranexamic acid","accessed":"2026-08-27"},{"id":"fda_txa_warn","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22TRANEXAMIC+ACID%22+AND+openfda.route:%22ORAL%22&limit=3","label":"US FDA label for tranexamic acid tablets (Nordic Pharma), section 5 Warnings and Precautions, via openFDA","quote":"Thromboembolism, including retinal occlusion, has been reported … Visual or ocular adverse reactions may occur … Cerebral edema and cerebral infarction may be caused by use … in patients with subarachnoid hemorrhage.","accessed":"2026-08-27"},{"id":"fda_txa_di","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22TRANEXAMIC+ACID%22+AND+openfda.route:%22ORAL%22&limit=3","label":"US FDA label for tranexamic acid tablets (Nordic Pharma), section 7 Drug Interactions, via openFDA","quote":"Concomitant therapy with tissue plasminogen activators may decrease the efficacy of both … not recommended in patients taking either Factor IX complex concentrates or anti-inhibitor coagulant concentrates … all-trans retinoic acid","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:33.302383+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}