{"ok":true,"entry":{"slug":"ticagrelor","kind":"medication","name":"ticagrelor","aliases":["Brilinta"],"brands_sg":["Ticaspan","Brilinta","Reclovac"],"class":"P2Y12 antiplatelet","tags":["heart-bp"],"use_for":"preventing clots after acute coronary syndrome — sg label","use_after":"ndf: at least 12 months is the recommended duration","use_duration":null,"take_with":"with or without food · grapefruit is to be avoided","pros":["healthhub: makes the blood less sticky to stop clots","ndf: no dose change for age or kidney function","brilinta, ticaspan and reclovac are the sg brands"],"cons":["bleeding — nosebleeds, gums, cuts, heavier periods","healthhub: feeling breathless easily is common","may need stopping before surgery or dental work"],"dose_note":"the sg label for brilinta states the ceiling as a single 180 mg loading dose then 90 mg twice daily: \"BRILINTA treatment should be initiated with a single 180 mg loading dose (two tablets of 90 mg) and then continued at 90 mg twice daily\", and after one year patients \"may continue treatment with 60 mg\" — as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["kidney or liver problems — healthhub precaution; ndf contraindicates severe hepatic impairment","a history of stomach or intestinal ulcers or bleeds, brain bleeding or other bleeding problems — healthhub","any planned medical, surgical or dental procedure — healthhub notes it may need stopping temporarily","active bleeding or a past intracranial haemorrhage — ndf contraindications"],"clashes":[{"src":["hh_ticagrelor_food"],"food":true,"note":"healthhub: may interact and increase the risk of side effects","with":"grapefruit"},{"src":["hh_ticagrelor_food","ndf_brilinta_ci"],"note":"healthhub names them as interacting antibacterials; ndf contraindicates strong cyp3a4 inhibitors including clarithromycin","with":"clarithromycin, erythromycin"},{"src":["hh_ticagrelor_food","ndf_brilinta_ci"],"note":"healthhub names them as interacting antifungals; ndf contraindicates ketoconazole as a strong cyp3a4 inhibitor","with":"itraconazole, ketoconazole"},{"src":["hh_ticagrelor_food","ndf_brilinta_ci"],"note":"healthhub names them as interacting antivirals; ndf contraindicates ritonavir and atazanavir","with":"atazanavir, darunavir, ritonavir"},{"src":["ndf_brilinta_asa"],"note":"ndf: taken together by design — a daily 75–150 mg maintenance dose of asa unless contraindicated","with":"aspirin (acetylsalicylic acid)"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084), Forensicclassification column; read from the cached copy at /tmp/hsa_all.json and filtered locally, not re-fetched","quote":"TICASPAN 90 FILM-COATED TABLETS 90MG SIN17211P; BRILINTA TABLET 60 MG SIN15294P; RECLOVAC 90 FILM COATED TABLETS 90MG SIN17266P; Brilinta Tablet 90 mg SIN14120P — all 4 ticagrelor rows read Prescription Only, ATC B01AC24","accessed":"2026-08-27"},{"id":"ndf_brilinta","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14120p/","label":"MOH National Drug Formulary (Singapore) — BRILINTA TABLET 90 MG [SIN14120P], product information","quote":"TICAGRELOR - 90 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code B01AC24 … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_brilinta_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14120p/","label":"MOH National Drug Formulary (Singapore) — BRILINTA [SIN14120P], section 4.1 Therapeutic indications","quote":"BRILINTA, co-administered with acetylsalicylic acid (ASA), is indicated for the prevention of thrombotic events (cardiovascular death, myocardial infarction and stroke) in patients with Acute Coronary Syndromes (ACS)","accessed":"2026-08-27"},{"id":"ndf_brilinta_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14120p/","label":"MOH National Drug Formulary (Singapore) — BRILINTA [SIN14120P], section 4.2 Posology and method of administration","quote":"BRILINTA treatment should be initiated with a single 180 mg loading dose (two tablets of 90 mg) and then continued at 90 mg twice daily. Treatment is recommended for at least 12 months","accessed":"2026-08-27"},{"id":"ndf_brilinta_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14120p/","label":"MOH National Drug Formulary (Singapore) — BRILINTA [SIN14120P], section 4.3 Contraindications","quote":"Active pathological bleeding. History of intracranial haemorrhage … Severe hepatic impairment … Co-administration of ticagrelor with strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, nefazodone, ritonavir, and atazanavir) is contraindicated","accessed":"2026-08-27"},{"id":"hh_ticagrelor","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ticagrelor","label":"HealthHub (MOH Singapore) — Ticagrelor, medication information leaflet, uses (article last reviewed 22 May 2026)","quote":"Ticagrelor belongs to the class of medications called antiplatelets. Antiplatelets are used to prevent blood clots from forming by making the blood less “sticky”. By preventing blood clots, this reduces the risk of you having a heart attack or stroke.","accessed":"2026-08-27"},{"id":"hh_ticagrelor_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ticagrelor","label":"HealthHub (MOH Singapore) — Ticagrelor, administration","quote":"Do not stop taking your medication without checking with your healthcare professional. You may take this medication with or without food.","accessed":"2026-08-27"},{"id":"hh_ticagrelor_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ticagrelor","label":"HealthHub (MOH Singapore) — Ticagrelor, precautions","quote":"You have kidney or liver problems. You have a history of stomach or intestinal ulcers or bleeds, bleeding in the brain or other bleeding problems. You are planned for any medical procedures, surgeries or dental procedures","accessed":"2026-08-27"},{"id":"hh_ticagrelor_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ticagrelor","label":"HealthHub (MOH Singapore) — Ticagrelor, common side effects","quote":"Feeling breathless easily … Mild bleeding such as: Unexplained nosebleed. Bleeding from gums when brushing teeth … Bleeding from small cuts for 10-15 minutes … Menstrual bleeding that is heavier than normal.","accessed":"2026-08-27"},{"id":"hh_ticagrelor_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ticagrelor","label":"HealthHub (MOH Singapore) — Ticagrelor, food and medication to avoid","quote":"Avoid taking grapefruit when you are taking this medication … Examples include: Medications for bacterial infections (e.g. clarithromycin, erythromycin) … fungal infections (e.g. itraconazole, ketoconazole) … viral infections (e.g. atazanavir, darunavir, ritonavir)","accessed":"2026-08-27"},{"id":"ndf_brilinta_asa","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14120p/","label":"MOH National Drug Formulary (Singapore) — BRILINTA [SIN14120P], section 4.2 Posology: continuation and companion aspirin dose","quote":"After one year, patients with MI initiated on 90 mg may continue treatment with 60 mg … Patients taking BRILINTA should also take a daily low maintenance dose of acetylsalicylic acid (ASA) of 75–150 mg","accessed":"2026-08-27"},{"id":"ndf_brilinta_pop","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14120p/","label":"MOH National Drug Formulary (Singapore) — BRILINTA [SIN14120P], section 4.2 Posology: special populations","quote":"Elderly patients: No dose adjustment is required. Patients with renal impairment: No dose adjustment is necessary for patients with renal impairment","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:33.302383+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}