{"ok":true,"entry":{"slug":"sulforaphane","kind":"supplement","name":"sulforaphane","aliases":["broccoli sprout extract","glucoraphanin"],"brands_sg":["Swanson Vitamins","Jarrow Formulas","NOW Foods","Life Extension","Best Naturals"],"class":"isothiocyanate","tags":["general"],"use_for":"limited human evidence — trials are in clinical groups","use_after":null,"use_duration":null,"take_with":null,"pros":["6 ASD trials (n = 333) lowered a social-response score","adverse-event rates matched placebo in the ASD trials","not named in HSA's prohibited or restricted annexes"],"cons":["no cognitive benefit in the schizophrenia meta-analysis","PANSS total and positive symptoms did not improve","no RDA, no upper limit, no SG cap set"],"dose_note":"pooled autism trials ran 4–10 weeks and schizophrenia trials reported 12-week and later follow-ups; the pooled summaries do not state a milligram dose","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["trials were in diagnosed patients, not healthy adults","no upper limit set — absence of a cap is not safety"],"clashes":[],"sources":[{"id":"sfn_scz","url":"https://europepmc.org/article/PMC/PMC12581406","label":"Efficacy and safety of sulforaphane in schizophrenia: systematic review and meta-analysis of RCTs (BMC Psychiatry 2025)","quote":"Four RCTs with 369 schizophrenia patients were included. Sulforaphane did not significantly improve PANSS total or positive symptom scores … No cognitive benefits were observed.","accessed":"2026-08-27"},{"id":"sfn_asd","url":"https://europepmc.org/article/PMC/PMC12751817","label":"Clinical efficacy, safety and molecular mechanism of sulforaphane in autism spectrum disorder: meta-analysis and network pharmacology (BMC Pharmacol Toxicol 2025)","quote":"Six trials involving 333 participants were included … 4-5 weeks and 8-10 weeks of sulforaphane supplementation significantly decreased the scores on the Social Responsiveness Scale … No significant difference … in the incidence of adverse events","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annexes A and B","quote":"Annex A: List of substances which are prohibited or restricted for use with conditions … Annex B: List of substances with potential safety issues [sulforaphane appears in neither annex]","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names sulforaphane]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/broccoli","label":"iHerb Singapore — Broccoli category page (Supplements > Greens & Superfoods > Super Greens), default order","quote":"Swanson Vitamins, Sulforaphane from Broccoli Sprout Extract, 400 mcg … Jarrow Formulas, Vegan BroccoMax, 120 Veggie Capsules … NOW Foods, Real Food, Broccoli Seeds … Life Extension, Optimized Broccoli and Myrosinase … Best Naturals, Broccoli Sprout Extract","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}