{"ok":true,"entry":{"slug":"spironolactone","kind":"medication","name":"spironolactone","aliases":["Aldactone"],"brands_sg":["Aldactone","Spirolon","Uractonum","Spiridon"],"class":"aldosterone antagonist","tags":["heart-bp"],"use_for":"prescribed for fluid build-up, heart failure, blood pressure","use_after":"healthhub: morning if once daily; second dose before 6pm","use_duration":null,"take_with":"food · nhs: with food or just after food","pros":["healthhub: in heart failure it improves survival","nhs: a liquid form exists as well as tablets","nhs: most adults and children can take it"],"cons":["nhs: breast pain and breast growth, including in men","healthhub: it raises blood potassium — tests needed","nhs: not usually recommended during pregnancy"],"dose_note":"the us fda label for aldactone gives an initial 25 mg once daily in heart failure, '25 to 100 mg of ALDACTONE administered in either single or divided doses' initially for essential hypertension with the note that 'Doses greater than 100 mg/day generally do not provide additional reductions in blood pressure', an initial 100 mg daily for oedema 'but may range from 25 to 200 mg daily', and '100 to 400 mg daily in preparation for surgery' in primary hyperaldosteronism — 400 mg daily is the highest figure the label prints. sg-registered strengths are 25, 50 and 100 mg. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["nhs: severe kidney problems, or addison's disease","nhs: a past high potassium level (hyperkalaemia)","nhs: trouble peeing from an underlying condition","pregnancy — nhs: not usually recommended"],"clashes":[{"src":["nhs_spiro_mix","nhs_spiro_food","fda_ald_inter"],"note":"nhs: potassium supplements and foods like bananas or lo-salt can raise potassium further; the fda label says the same","with":"potassium supplements and salt substitutes"},{"src":["fda_ald_contra","nhs_spiro_mix"],"note":"fda label: concomitant use is contraindicated; nhs lists eplerenone among medicines that may not mix well","with":"eplerenone"},{"src":["nhs_spiro_mix","fda_ald_inter"],"note":"nhs lists digoxin; the fda label notes spironolactone can interfere with radioimmunologic digoxin assays","with":"digoxin"},{"src":["nhs_spiro_mix","fda_ald_inter"],"note":"nhs lists nsaids; the fda label says they may reduce the diuretic and antihypertensive effect","with":"nsaids (ibuprofen, aspirin, diclofenac)"},{"src":["fda_ald_inter"],"note":"fda label: increased risk of lithium toxicity","with":"lithium"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 7 registered single-ingredient spironolactone products carry Forensicclassification 'Prescription Only', ATC C03DA01 — SIN02222P ALDACTONE TABLET 25 mg · SIN02153P/SIN02168P SPIROLON 25 and 100 · SIN00664P URACTONUM 25 mg · SIN16709-11P SPIRIDON 25/50/100MG.","accessed":"2026-08-27"},{"id":"nhs_spiro_about","url":"https://www.nhs.uk/medicines/spironolactone/","label":"NHS Medicines A-Z — Spironolactone: what spironolactone is for","quote":"Spironolactone is a medicine used to treat swelling caused by fluid build-up. It can also be used for high blood pressure and heart failure. It's only available with a prescription.","accessed":"2026-08-27"},{"id":"nhs_spiro_howto","url":"https://www.nhs.uk/medicines/spironolactone/","label":"NHS Medicines A-Z — Spironolactone: how to take spironolactone","quote":"Spironolactone usually comes as tablets or a liquid you swallow. Your dose and how long you take it for depends on why you're taking it … take it with food or just after food","accessed":"2026-08-27"},{"id":"nhs_spiro_side","url":"https://www.nhs.uk/medicines/spironolactone/","label":"NHS Medicines A-Z — Spironolactone: side effects","quote":"Common side effects of spironolactone include: feeling dizzy; feeling sick (nausea); muscle or leg cramps; feeling tired or low in energy; breast pain and increase in breast size, including in men","accessed":"2026-08-27"},{"id":"nhs_spiro_who","url":"https://www.nhs.uk/medicines/spironolactone/","label":"NHS Medicines A-Z — Spironolactone: who can and cannot take it","quote":"You may not be able to take spironolactone if you: … have severe kidney problems; are unable to pee properly …; have Addison's disease …; have ever had high levels of potassium in your blood","accessed":"2026-08-27"},{"id":"nhs_spiro_preg","url":"https://www.nhs.uk/medicines/spironolactone/","label":"NHS Medicines A-Z — Spironolactone: pregnancy and breastfeeding","quote":"Spironolactone is not usually recommended during pregnancy. This is because it can potentially affect a baby's development.","accessed":"2026-08-27"},{"id":"nhs_spiro_mix","url":"https://www.nhs.uk/medicines/spironolactone/","label":"NHS Medicines A-Z — Spironolactone: taking it with other medicines","quote":"digoxin, a medicine used to treat an irregular heartbeat; some medicines to treat high blood pressure and heart failure, such as eplerenone; supplements containing potassium; non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, aspirin and diclofenac","accessed":"2026-08-27"},{"id":"nhs_spiro_food","url":"https://www.nhs.uk/medicines/spironolactone/","label":"NHS Medicines A-Z — Spironolactone: food, drink and alcohol","quote":"Eating foods like bananas and avocados, or salt substitutes such as Lo-Salt, while taking spironolactone can raise potassium levels further. Ask a doctor or dietitian for advice.","accessed":"2026-08-27"},{"id":"hh_spiro_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/spironolactone","label":"HealthHub (Pharmaceutical Society of Singapore) — Spironolactone: what is this medication for","quote":"This medication is used in heart failure to improve the survival rate, reduce the symptoms of heart failure such as breathlessness or leg swelling and reduce the chance of being admitted to the hospital because of heart failure.","accessed":"2026-08-27"},{"id":"hh_spiro_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/spironolactone","label":"HealthHub — Spironolactone: how should I take or use this medication","quote":"You should take this medication with or after food. If you are taking one dose a day, take it in the morning. If you are taking the medicine two times a day, take the second dose before 6pm","accessed":"2026-08-27"},{"id":"hh_spiro_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/spironolactone","label":"HealthHub — Spironolactone: common side effects","quote":"Increased potassium levels in your blood. Your doctor may monitor your potassium levels and kidney function regularly when you are on this medication.","accessed":"2026-08-27"},{"id":"fda_ald_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ALDACTONE%22&limit=1","label":"US FDA label for ALDACTONE (spironolactone), section 2 Dosage and Administration, via openFDA drug/label.json (effective 2025-11-28)","quote":"The recommended initial daily dose is 25 to 100 mg … Doses greater than 100 mg/day generally do not provide additional reductions in blood pressure … doses of 100 to 400 mg daily in preparation for surgery","accessed":"2026-08-27"},{"id":"fda_ald_contra","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ALDACTONE%22&limit=1","label":"US FDA label for ALDACTONE, section 4 Contraindications, via openFDA","quote":"ALDACTONE is contraindicated in the patients with: Hyperkalemia; Addison's disease; Concomitant use of eplerenone","accessed":"2026-08-27"},{"id":"fda_ald_inter","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ALDACTONE%22&limit=1","label":"US FDA label for ALDACTONE, section 7 Drug Interactions, via openFDA","quote":"Agents increasing serum potassium: Concomitant administration can lead to hyperkalemia. Lithium: Increased risk of lithium toxicity. NSAIDs: May reduce the diuretic, natriuretic and antihypertensive effect of ALDACTONE. Digoxin: ALDACTONE can interfere with radioimmunologic assays","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}