{"ok":true,"entry":{"slug":"solifenacin","kind":"medication","name":"solifenacin","aliases":["Vesicare"],"brands_sg":["Vesicare","Synerrv","Solicin-5","Bladiton","Dalisoon"],"class":"antimuscarinic","tags":["other"],"use_for":"overactive bladder — urgency, frequency and leaks","use_after":"sg label: 5 mg once daily, with or without food","use_duration":null,"take_with":"water — the sg label says tablets are swallowed whole","pros":["sg label: one tablet a day, food makes no difference","sg label: the dose can be stepped up to 10 mg if needed","hsa: five generic brands registered besides vesicare"],"cons":["healthhub: dry mouth, dry eyes and constipation","healthhub: drowsiness and dizziness can affect driving","healthhub: the body can overheat in hot weather"],"dose_note":"the singapore package insert for vesicare tablet 5mg (SIN13702P), as published on the moh national drug formulary, states \"The recommended dose is 5 mg solifenacin succinate once daily. If needed, the dose may be increased to a maximum of 10 mg solifenacin succinate once daily\" — 10 mg once daily is the adult label maximum, and the same insert caps it lower in three cases: severe renal impairment (creatinine clearance ≤30 mL/min) and moderate hepatic impairment (Child-Pugh B) each \"receive no more than 5 mg once daily\", and with ketoconazole or other potent cyp3a4 inhibitors \"The maximum dose of Vesicare should be limited to 5 mg\". the insert also says solifenacin \"is not indicated for treatment of OAB in the pediatric population\". in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["urinary retention or gastric retention — sg label contraindications","uncontrolled narrow-angle glaucoma — an sg label contraindication","myasthenia gravis or severe bowel disease — sg label contraindications","liver, kidney or heart problems (healthhub)"],"clashes":[{"src":["ndf_vesi_dose","nhs_soli_int"],"note":"sg label: the maximum dose should be limited to 5 mg when taken together","with":"ketoconazole, ritonavir, itraconazole and other potent cyp3a4 inhibitors"},{"src":["hh_soli_avoid"],"food":true,"note":"healthhub: may interact and increase the risk of side effects","with":"grapefruit and grapefruit juice"},{"src":["hh_soli_avoid"],"food":true,"note":"healthhub: may increase the risk of dizziness, light-headedness or drowsiness","with":"alcohol"},{"src":["nhs_soli_int"],"note":"nhs: taking solifenacin as well might make dry mouth, drowsiness or difficulty peeing worse","with":"other drying or drowsy-making medicines"},{"src":["hh_soli_prec"],"note":"healthhub: the combination may affect dementia treatment","with":"cholinesterase inhibitors (galantamine, donepezil, rivastigmine)"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; 5,511 rows cached at /tmp/hsa_all.json and filtered locally, never re-fetched — 8 solifenacin rows","quote":"All 8 registered solifenacin succinate products read \"Prescription Only\", ATC G04BD08, oral film-coated tablets 5 mg or 10 mg — Vesicare SIN13702P/SIN13703P, SYNERRV, SOLICIN-5, BLADITON, DALISOON and RENAXIN.","accessed":"2026-08-27"},{"id":"ndf_vesi_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13702p/","label":"MOH National Drug Formulary — VESICARE TABLET 5MG [SIN13702P], Indications (SG package insert)","quote":"Vesicare is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency or increased urinary frequency.","accessed":"2026-08-27"},{"id":"ndf_vesi_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13702p/","label":"MOH National Drug Formulary — VESICARE TABLET 5MG [SIN13702P], Dosage and Administration","quote":"The recommended dose is 5 mg solifenacin succinate once daily. If needed, the dose may be increased to a maximum of 10 mg solifenacin succinate once daily … swallowed whole with liquids … with or without food.","accessed":"2026-08-27"},{"id":"ndf_vesi_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13702p/","label":"MOH National Drug Formulary — VESICARE TABLET 5MG [SIN13702P], Contraindications","quote":"patients with urinary retention … uncontrolled narrow-angle glaucoma … severe gastro-intestinal condition (including toxic megacolon and gastric retention) … myasthenia gravis … patients undergoing haemodialysis … severe hepatic impairment","accessed":"2026-08-27"},{"id":"ndf_vesi_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13702p/","label":"MOH National Drug Formulary — VESICARE TABLET 5MG [SIN13702P], product information block","quote":"Forensic Classification: PRESCRIPTION ONLY MEDICINES · Anatomical Therapeutic Chemical (ATC) code G04BD08 · Prescription-only Medicines with Exemptions for Supply without Prescription: NA","accessed":"2026-08-27"},{"id":"hh_soli_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/solifenacin","label":"HealthHub (National Medication Information workgroup / Pharmaceutical Society of Singapore) — Solifenacin: what is this medication for","quote":"Solifenacin is used to treat a condition called overactive bladder … a strong need to urinate with leaking or wetting incidence (urinary incontinence); a strong need to urinate right away (urgency); urinating often (frequency)","accessed":"2026-08-27"},{"id":"hh_soli_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/solifenacin","label":"HealthHub — Solifenacin: how should I take or use this medication","quote":"This medication is usually taken once a day. You may take this medication with or without food.","accessed":"2026-08-27"},{"id":"hh_soli_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/solifenacin","label":"HealthHub — Solifenacin: what precautions should I take","quote":"You are not able to empty your bladder (urinary retention) … delayed or slow emptying of your stomach … uncontrolled narrow angle glaucoma … liver, kidney or heart problems … dementia and is taking … Galantamine, Donepezil, Rivastigmine","accessed":"2026-08-27"},{"id":"hh_soli_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/solifenacin","label":"HealthHub — Solifenacin: common side effects","quote":"Drowsiness — May affect your ability to drive and use machinery … Dizziness … Dry Mouth … Dry Eyes … Constipation … Overheating of the body — Monitor your body temperature, especially if you are in hot climates.","accessed":"2026-08-27"},{"id":"hh_soli_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/solifenacin","label":"HealthHub — Solifenacin: what food or medication should I avoid","quote":"Avoid taking grapefruit, or grapefruit juice as they may interact with your medication and increase the risk of side-effects. Avoid drinking alcohol as it may increase the risk of dizziness, light-headedness or drowsiness.","accessed":"2026-08-27"},{"id":"nhs_soli_hub","url":"https://www.nhs.uk/medicines/solifenacin/","label":"NHS — Solifenacin: a medicine to treat symptoms of an overactive bladder (brand name Vesicare)","quote":"Solifenacin - Brand name: Vesicare. Find out how solifenacin treats symptoms of an overactive bladder, such as needing to pee more often, and how to take it.","accessed":"2026-08-27"},{"id":"nhs_soli_int","url":"https://www.nhs.uk/medicines/solifenacin/taking-solifenacin-with-other-medicines-and-herbal-supplements/","label":"NHS — Taking solifenacin with other medicines and herbal supplements","quote":"any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee – taking solifenacin might make these side effects worse; itraconazole … ritonavir","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}