{"ok":true,"entry":{"slug":"sitagliptin","kind":"medication","name":"sitagliptin","aliases":["Januvia"],"brands_sg":["Januvia","Pansiptin","Sitavitae","Jimandin","Instadip"],"class":"DPP-4 inhibitor","tags":["diabetes"],"use_for":"prescribed for type 2 diabetes, with diet and exercise","use_after":"nhs: once a day, at the same time each day","use_duration":null,"take_with":"healthhub: before or after food · nhs: swallowed whole","pros":["nhs: one tablet a day, with or without food","healthhub: raises insulin release after a meal","sg register lists 25, 50 and 100 mg tablets"],"cons":["nhs: with other diabetes medicines it can cause hypos","healthhub: pancreatitis is a rare but serious risk","nhs: rare rash or blisters — stevens-johnson syndrome"],"dose_note":"the us januvia label states \"The recommended dose of JANUVIA is 100 mg once daily. JANUVIA can be taken with or without food\" — 100 mg once daily is the adult label ceiling, and the same label sets 50 mg once daily at an egfr of 30 to under 45 mL/min/1.73 m2 and 25 mg once daily below 30 or on dialysis. the sg register carries 25, 50 and 100 mg tablets. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["pancreatitis, gallstones, frequent alcohol or high triglycerides — healthhub: these raise the chance of pancreatitis","kidney problems — healthhub asks that this be declared before starting","pregnant, planning pregnancy or breastfeeding (healthhub)","fasting blood tests — healthhub: the dose is not taken until blood has been drawn and you have eaten"],"clashes":[{"src":["hh_sita_avoid"],"food":true,"note":"healthhub: it increases the chance of developing pancreatitis","with":"alcohol"},{"src":["nhs_sita_mix"],"note":"nhs: your doctor may want to change your dose","with":"insulin, metformin or gliclazide"},{"src":["nhs_sita_mix"],"note":"nhs lists digoxin among medicines that may not mix well","with":"digoxin"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), sitagliptin rows, 27 Aug 2026","quote":"JANUVIA 25/50/100 mg SIN13259P/SIN13258P/SIN13257P · PANSIPTIN SIN17192P · SITAVITAE SIN17161P · JIMANDIN SIN17267P · INSTADIP SIN17476P — ATC A10BH01; all 39 sitagliptin rows read Forensicclassification \"Prescription Only\"","accessed":"2026-08-27"},{"id":"nhs_sita_about","url":"https://www.nhs.uk/medicines/sitagliptin/","label":"NHS medicines A–Z — Sitagliptin: what sitagliptin is for (reviewed 19 August 2026)","quote":"Sitagliptin is a medicine used to treat type 2 diabetes. It's only available with a prescription … Sitagliptin works by increasing insulin in your body to lower your blood sugar level.","accessed":"2026-08-27"},{"id":"nhs_sita_howto","url":"https://www.nhs.uk/medicines/sitagliptin/","label":"NHS medicines A–Z — Sitagliptin: how to take sitagliptin","quote":"Sitagliptin comes as tablets you take once a day … take it at the same time each day; swallow your tablets whole with a glass of water; you can take it with or without food","accessed":"2026-08-27"},{"id":"nhs_sita_side","url":"https://www.nhs.uk/medicines/sitagliptin/","label":"NHS medicines A–Z — Sitagliptin: side effects","quote":"A common side effect of sitagliptin is headaches … If you take sitagliptin alongside other diabetes medicines, it may cause low blood sugar (hypoglycaemia, or a hypo) … an itchy or painful rash, mouth ulcers or blisters … Stevens-Johnson syndrome","accessed":"2026-08-27"},{"id":"nhs_sita_mix","url":"https://www.nhs.uk/medicines/sitagliptin/","label":"NHS medicines A–Z — Sitagliptin: taking sitagliptin with other medicines","quote":"You may not be able to take: medicines for high blood sugar, such as insulin, metformin and gliclazide; digoxin, a medicine for heart problems. If you take any of these medicines, your doctor may want to change your dose.","accessed":"2026-08-27"},{"id":"hh_sita_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sitagliptin","label":"HealthHub (Pharmaceutical Society of Singapore / MOH) — Sitagliptin: what is this medication for","quote":"Sitagliptin is used in the treatment of diabetes by helping to increase the insulin release after a meal and decrease the amount of sugar made by the liver. It works together with lifestyle changes","accessed":"2026-08-27"},{"id":"hh_sita_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sitagliptin","label":"HealthHub — Sitagliptin: how should I take or use this medication","quote":"This medication is taken once a day. You may take this medication before food or after food.","accessed":"2026-08-27"},{"id":"hh_sita_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sitagliptin","label":"HealthHub — Sitagliptin: what precautions should I take","quote":"Have pancreas problems such as pancreatitis … Have gallstones, drink alcohol very often or have very high levels of triglycerides … Have kidney problems … do not take your medication until your blood has been taken","accessed":"2026-08-27"},{"id":"hh_sita_serious","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sitagliptin","label":"HealthHub — Sitagliptin: rare but serious side effects","quote":"Pancreatitis (inflammation of the pancreas) is a rare but serious side effect of this medication. Symptoms of pancreatitis include: Severe pain in the stomach, abdomen or back area","accessed":"2026-08-27"},{"id":"hh_sita_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sitagliptin","label":"HealthHub — Sitagliptin: what food or medication should I avoid","quote":"Avoid taking alcohol with this medication as this increases your chances of developing pancreatitis.","accessed":"2026-08-27"},{"id":"fda_januvia_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22JANUVIA%22&limit=1","label":"JANUVIA (sitagliptin) tablets — US prescribing information (Merck, effective 2026-07-08) via openFDA drug/label.json, section 2 Dosage and Administration","quote":"The recommended dose of JANUVIA is 100 mg once daily. JANUVIA can be taken with or without food … eGFR 30 to less than 45: 50 mg once daily; eGFR less than 30: 25 mg once daily","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}