{"ok":true,"entry":{"slug":"shiitake","kind":"supplement","name":"shiitake","aliases":["Lentinula edodes","lentinan","AHCC source"],"brands_sg":["California Gold Nutrition","Swanson Vitamins","Nutricost","Nature's Answer","Super Nutrition"],"class":"mushroom","tags":["immune"],"use_for":"immune and gut markers — most data is lab and animal","use_after":null,"use_duration":null,"take_with":"cooked · raw or undercooked shiitake is tied to a rash","pros":["classified as a functional food, widely eaten","glucans raised microbial diversity and ifn-γ","a 2025 review reports clinical trials alongside chemo"],"cons":["most evidence is in vitro and in animal models","the review calls for randomized trials to confirm","raw or undercooked shiitake can trigger a rash"],"dose_note":"no supplement dose is established for shiitake; the 2025 review reports that l. edodes glucans have been combined with standard chemotherapy in clinical trials and that they increase microbial diversity and interferon-gamma production, while saying randomized trials and long-term follow-up are still needed","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["raw or undercooked shiitake — flagellate dermatitis, an itchy whip-like rash, is reported after ingestion and was managed with oral and topical steroids in the case sourced here","the clinical data cited by the 2025 review is in people already on chemotherapy, not general use","the anti-inflammatory and anticancer findings quoted are from in vitro and animal models","not listed in hsa's annex a/b — hsa says that list is not exhaustive"],"clashes":[],"sources":[{"id":"le2025_scope","url":"https://europepmc.org/article/PMC/PMC11989352","label":"Lentinula edodes as a Source of Bioactive Compounds with Therapeutical Potential in Intestinal Inflammation and Colorectal Cancer (Int J Mol Sci 2025) — scope","quote":"There is evidence suggesting that bioactive substances in Lentinula edodes have immunomodulatory and anticancer properties. This fungus is currently classified as a functional food, considering its beneficial effects on human health and special nutritional value.","accessed":"2026-08-27"},{"id":"le2025_preclinical","url":"https://europepmc.org/article/PMC/PMC11989352","label":"Lentinula edodes review, Int J Mol Sci 2025 — where the evidence comes from","quote":"Studies conducted in vitro and in animal models demonstrated that L. edodes bioactive compounds, in particular glucans, have anti-inflammatory and antioxidant effects, induce apoptosis of cancer cells, reduce tumor angiogenesis, restore gut microbiome heterogeneity","accessed":"2026-08-27"},{"id":"le2025_clinical","url":"https://europepmc.org/article/PMC/PMC11989352","label":"Lentinula edodes review, Int J Mol Sci 2025 — clinical findings reported","quote":"Moreover, clinical trials confirmed that these compounds combined with standard chemotherapy have a significant effect in improving the prognosis of CRC patients. In addition, L. edodes glucans increase microbial diversity and enhance interferon (IFN)-γ production by immune cells.","accessed":"2026-08-27"},{"id":"le2025_gap","url":"https://europepmc.org/article/PMC/PMC11989352","label":"Lentinula edodes review, Int J Mol Sci 2025 — what is still missing","quote":"Moreover, both randomized trials and long-term follow-up studies are needed to confirm their effectiveness in the treatment of IBD and CRC.","accessed":"2026-08-27"},{"id":"shiitake_derm2024","url":"https://europepmc.org/article/PMC/PMC11284235","label":"Shiitake mushroom-induced flagellate dermatitis: The first case reported in Nepal (Clin Case Rep 2024)","quote":"Shiitake mushroom-induced flagellate dermatitis is a rare but important condition to consider in patients presenting with pruritic skin lesions following mushroom ingestion … appropriate management with oral and topical steroids","accessed":"2026-08-27"},{"id":"shiitake_derm2024_raw","url":"https://europepmc.org/article/PMC/PMC11284235","label":"Shiitake flagellate dermatitis case report, Clin Case Rep 2024 — raw and undercooked shiitake","quote":"Educating patients about the risks associated with consuming raw or undercooked shiitake mushrooms is essential to prevent recurrence.","accessed":"2026-08-27"},{"id":"mush2026_species","url":"https://europepmc.org/article/PMC/PMC13209540","label":"Medicinal Mushrooms and Their Bioactive Compounds: From Traditional Use to Therapeutic Potential (Molecules 2026) — species in scope","quote":"Among the most widely studied and utilized species are Ganoderma lucidum, Lentinula edodes, Grifola frondosa, Cordyceps militaris, Cordyceps sinensis, Trametes versicolor, and Inonotus obliquus.","accessed":"2026-08-27"},{"id":"hsa_pr_notlisted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A/B — searched, no row for this ingredient","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/shiitake","label":"iHerb Singapore — Shiitake category (default order, 13 results); first 5 distinct brands: California Gold Nutrition, Swanson Vitamins, Nutricost, Nature's Answer, Super Nutrition","quote":"California Gold Nutrition, Fungiology® Certified Organic Shiitake Powder … Swanson Vitamins, Full Spectrum® Shiitake Mushroom, 500 mg … Nutricost, Shiitake Mushroom … Nature's Answer, Shiitake Extract, Alcohol-Free … Super Nutrition, Organic Shiitake Mushroom + Ginger","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}