{"ok":true,"entry":{"slug":"semaglutide","kind":"medication","name":"semaglutide","aliases":["Ozempic","Rybelsus","Wegovy"],"brands_sg":["Wegovy","Rybelsus","Ozempic"],"class":"GLP-1 receptor agonist","tags":["diabetes"],"use_for":"prescribed for type 2 diabetes or obesity — a doctor decides","use_after":"nhs: the injection is weekly; the tablets are daily","use_duration":null,"take_with":"nhs tablets: water only, then 30 minutes before food","pros":["nhs: the injection is once a week, any time of day","hsa: injection and tablet forms both registered in sg","nhs: reduces appetite alongside diet and exercise"],"cons":["nhs: nausea, vomiting, constipation, diarrhoea","nhs: rare pancreatitis and worsening eye disease","nhs: not used in pregnancy or while breastfeeding"],"dose_note":"the three sg-registered semaglutide products carry three different label ceilings. the us fda label for ozempic injection: 'The recommended maintenance dosage is 0.5 mg, 1 mg, or 2 mg, injected subcutaneously once weekly, based on glycemic control'. for wegovy: 'The maintenance dosage of WEGOVY in adults is either 2.4 mg (recommended) or 1.7 mg once weekly'. for rybelsus tablets the label escalates to '14 mg orally once daily' if additional glycemic control is needed, and adds 'Do not take more than one tablet per day'. sg-registered strengths are rybelsus 3/7/14 mg tablets, ozempic pens up to 1 mg/dose and wegovy pens up to 2.4 mg/dose. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["past or current pancreatitis (nhs)","pregnancy, or planning one within the next 2 months (nhs)","diabetic eye disease — nhs: retinopathy can get worse","insulin or other diabetes medicines already in use (nhs)"],"clashes":[{"src":["nhs_sema_mix","nhs_sema_side"],"note":"nhs: a doctor or specialist nurse may need to adjust the insulin dose; low blood sugar is more likely with other diabetes medicines","with":"insulin"},{"src":["nhs_sema_mix"],"note":"nhs lists them among medicines that may not mix well with semaglutide","with":"metformin, gliclazide and other type 2 diabetes medicines"},{"src":["nhs_sema_mix"],"note":"nhs lists some medicines to reduce blood clots among those that may not mix well","with":"warfarin and other clot-reducing medicines"},{"src":["nhs_sema_mix"],"note":"nhs lists levothyroxine, for an underactive thyroid, among medicines that may not mix well","with":"levothyroxine"},{"src":["nhs_sema_mix"],"note":"nhs: tell the healthcare professional you are using semaglutide before an operation or dental procedure","with":"a general anaesthetic or sedative"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered offline)","quote":"All 15 registered semaglutide products carry Forensicclassification 'Prescription Only' (ATC A10BJ06) — 10 WEGOVY rows to 2.4 mg/dose, 3 RYBELSUS tablet rows (3, 7, 14 mg) and 2 OZEMPIC injection rows (0.25/0.5 mg and 1 mg per dose).","accessed":"2026-08-27"},{"id":"nhs_sema_about","url":"https://www.nhs.uk/medicines/semaglutide/","label":"NHS Medicines A-Z — Semaglutide: what semaglutide is for","quote":"Semaglutide is a GLP-1 agonist medicine that can be used to treat type 2 diabetes, heart disease or obesity. It's only available with a prescription … works for weight loss by reducing your appetite","accessed":"2026-08-27"},{"id":"nhs_sema_howto","url":"https://www.nhs.uk/medicines/semaglutide/","label":"NHS Medicines A-Z — Semaglutide: how to use semaglutide","quote":"Semaglutide comes as an injection that you give yourself once a week or tablets that you take once a day … wait at least 30 minutes before eating, drinking or taking other medicines … swallow tablets whole","accessed":"2026-08-27"},{"id":"nhs_sema_side","url":"https://www.nhs.uk/medicines/semaglutide/","label":"NHS Medicines A-Z — Semaglutide: side effects","quote":"Common side effects of semaglutide include: feeling sick (nausea) and being sick (vomiting); constipation; diarrhoea; feeling tired … Possible serious side effects … diabetic retinopathy getting worse … an inflamed pancreas (acute pancreatitis) … low blood sugar","accessed":"2026-08-27"},{"id":"nhs_sema_who","url":"https://www.nhs.uk/medicines/semaglutide/","label":"NHS Medicines A-Z — Semaglutide: who can and cannot use it, pregnancy and breastfeeding","quote":"it may not be suitable if: … you have or have had an inflamed pancreas (acute pancreatitis) … not used while breastfeeding … not used during pregnancy … stop at least 2 months before you start trying","accessed":"2026-08-27"},{"id":"nhs_sema_mix","url":"https://www.nhs.uk/medicines/semaglutide/","label":"NHS Medicines A-Z — Semaglutide: using it with other medicines, food and drink","quote":"some medicines to reduce blood clots such as warfarin; levothyroxine, for an underactive thyroid; insulin – your doctor or specialist nurse may need to adjust your dose; other type 2 diabetes medicines … a general anaesthetic","accessed":"2026-08-27"},{"id":"fda_ozempic_inj_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22OZEMPIC%22+AND+openfda.route:%22SUBCUTANEOUS%22&limit=1","label":"US FDA label for OZEMPIC (semaglutide) injection, section 2.2 Recommended Dosage, via openFDA drug/label.json (effective 2026-07-30)","quote":"The recommended maintenance dosage is 0.5 mg, 1 mg, or 2 mg, injected subcutaneously once weekly, based on glycemic control.","accessed":"2026-08-27"},{"id":"fda_wegovy_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22WEGOVY%22&limit=1","label":"US FDA label for WEGOVY (semaglutide) injection, section 2.2 Recommended Dosage in Adults, via openFDA drug/label.json (effective 2024-04-23)","quote":"The maintenance dosage of WEGOVY in adults is either 2.4 mg (recommended) or 1.7 mg once weekly. The maintenance dosage of WEGOVY in pediatric patients aged 12 years and older is 2.4 mg once weekly.","accessed":"2026-08-27"},{"id":"fda_rybelsus_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22OZEMPIC%22&limit=1","label":"US FDA label for RYBELSUS (semaglutide) tablets, section 2.2 Recommended Dosage, via openFDA drug/label.json (effective 2026-01-30)","quote":"On Day 61 or thereafter, if: … Additional glycemic control is needed, increase the dosage to 14 mg orally once daily … Do not take more than one tablet per day.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}