{"ok":true,"entry":{"slug":"schisandra","kind":"supplement","name":"schisandra","aliases":["Schisandra chinensis","wu wei zi"],"brands_sg":["Nature's Way","Nature's Answer","Swanson Vitamins","Oregon's Wild Harvest","Solaray"],"class":"botanical","tags":["energy","general"],"use_for":"promoted for endurance and anti-aging — evidence is thin","use_after":null,"use_duration":null,"take_with":null,"pros":["long traditional use — over 2,000 years on record","animal work is extensive — 54 studies pooled in 2025","12-week omija-mix trial: no safety signal seen"],"cons":["the 2019 review rests on molecular and animal work","no human trial on energy or endurance was found","sg labels cannot claim liver or fatty-liver benefits"],"dose_note":"no rda, upper limit, fda daily value or hsa singapore daily limit exists for schisandra; the only human trial found in the sources read ran 12 weeks on an omija (schisandra) extract and soybean mixture, not schisandra alone, and its abstract reports no dose — so none is stated here; the largest body of evidence, a 2025 systematic review pooling 54 studies, is entirely animal work and no human dose can be read off it; capsules listed on iherb singapore run about 525-580 mg of berry powder or standardised extract","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["human safety data in the sources read is one 12-week trial of a mixture, not of schisandra alone","the large 2025 evidence base is animal, not human — it says efficacy and safety still need validating","not listed in hsa's prohibited or restricted annexes — that is not a safety finding"],"clashes":[],"sources":[{"id":"schis_review","url":"https://europepmc.org/article/PMC/PMC6412213","label":"Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review of Current Knowledge and Therapeutic Perspectives (Nowak et al., Nutrients 2019)","quote":"SCE … improves physical endurance and cognitive/behavioural functions, which can be linked with its general anti-aging potency … Further research is needed to determine the molecular mechanisms of SCE action.","accessed":"2026-08-27"},{"id":"schis_review_basis","url":"https://europepmc.org/article/PMC/PMC6412213","label":"Nowak et al., Nutrients 2019 — basis of the evidence","quote":"Schisandra chinensis (Turcz.) Baill. (SCE) is a plant with high potential for beneficial health effects, confirmed by molecular studies.","accessed":"2026-08-27"},{"id":"schis_liver","url":"https://europepmc.org/article/PMC/PMC12358260","label":"Efficacy of Schisandra chinensis in liver injury: a systematic review and preclinical meta-analysis (Huang et al., Front Pharmacol 2025)","quote":"Schisandra chinensis, a traditional Chinese medicinal herb with a history of use spanning over 2,000 years … A total of 54 animal studies were included in this review … further research is needed to validate its efficacy and safety.","accessed":"2026-08-27"},{"id":"schis_omija","url":"https://europepmc.org/article/PMC/PMC9370295","label":"Efficacy and Safety of Omija (Schisandra chinensis) Extract Mixture on the Improvement of Hyperglycemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial (Nutrients 2022)","quote":"we conducted a 12-week, randomized, double-blinded, and placebo-controlled clinical trial to determine the effects of OSM in humans … No clinically significant changes in any safety parameter were observed.","accessed":"2026-08-27"},{"id":"hsa_prohibited","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A (118 rows) and Annex B (4 rows) — schisandra / Schisandra chinensis / wu wei zi NOT LISTED in either annex","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs_claims","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 6.6 and Table 6 (prohibited claims) — Digestive system row: Ulcers, gastritis, hepatitis, liver cirrhosis, fatty liver, diarrhoea, constipation, inflammation of the intestines, liver or pancreas","quote":"HS must not be labelled, advertised or promoted for any specific medicinal purpose, i.e. treatment or prevention, implied or otherwise, of any disease or disorder … Digestive system: Ulcers, gastritis, hepatitis, liver cirrhosis, fatty liver","accessed":"2026-08-27"},{"id":"hsa_hs_limits","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4-5 (vitamins and minerals only — no botanical rows)","quote":"4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/schisandra-schizandra","label":"iHerb Singapore — Schisandra (Schizandra) category page, default listing order","quote":"1 - 12 of 12 results … Nature's Way, Schisandra Fruit … Nature's Answer, Schisandra Extract … Swanson Vitamins, Full Spectrum Schizandra Berries, 525 mg … Oregon's Wild Harvest, Organic Schisandra … Solaray, True Herbs, Schizandra, 580 mg","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}