{"ok":true,"entry":{"slug":"salmeterol","kind":"medication","name":"salmeterol","aliases":["Seretide (with fluticasone)"],"brands_sg":["Seretide Accuhaler","Seretide Evohaler","Respiro","Salflumix Easyhaler"],"class":"long-acting beta-2 agonist","tags":["respiratory"],"use_for":"regular asthma or copd control, not sudden attacks","use_after":"seretide label: one inhalation twice daily, every day","use_duration":null,"take_with":"an inhaled steroid · sg registers it only with fluticasone","pros":["smpc: regular asthma control with an inhaled steroid","smpc: one inhalation twice daily, lowest effective dose","smpc: 50/500 twice daily also covers copd symptoms"],"cons":["us label: laba alone raises asthma-death risk","smpc: not for acute symptoms — a reliever is needed","smpc: tremor, palpitations, headache can occur"],"dose_note":"the uk seretide accuhaler label's highest listed regimen is 'One inhalation of 50 micrograms salmeterol and 500 micrograms fluticasone propionate twice daily' (asthma in adults/adolescents 12+, and copd), with the dose 'titrated to the lowest dose at which effective control of symptoms is maintained'. the us serevent diskus label states that 'more than 1 inhalation twice daily' is not recommended, and the us advair label puts 'the maximum recommended dosage' at 500/50 twice daily — so 50 mcg of salmeterol twice daily is the ceiling in every label read. the prescriber sets the strength.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["severe heart disease or heart-rhythm problems (seretide smpc)","diabetes, thyrotoxicosis or low blood potassium (smpc)","active or past tuberculosis, airway infections (smpc)","copd — smpc reports more pneumonia on inhaled steroids"],"clashes":[{"src":["emc_seretide_int"],"note":"smpc: may weaken or antagonise the effect of salmeterol","with":"beta-blockers"},{"src":["emc_seretide_int"],"note":"smpc: raises salmeterol exposure; qtc prolongation and palpitations","with":"ketoconazole and other potent cyp3a4 inhibitors"},{"src":["emc_seretide_warn"],"note":"smpc: greatly raises fluticasone levels in the combination inhaler","with":"ritonavir"},{"src":["emc_seretide_int"],"note":"smpc: hypokalaemia from beta-2 agonists may be potentiated","with":"xanthines, steroids and diuretics"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 10 registered salmeterol products are fluticasone-salmeterol combinations classified 'Prescription Only' — SERETIDE EVOHALER 25/50, 25/125, 25/250 · SERETIDE 50/100, 50/250, 50/500 ACCUHALER · RESPIRO · SALFLUMIX EASYHALER","accessed":"2026-08-27"},{"id":"emc_seretide_ind","url":"https://www.medicines.org.uk/emc/product/7596/smpc","label":"UK SmPC — Seretide 500 Accuhaler (GlaxoSmithKline), section 4.1 Therapeutic indications, via emc","quote":"Seretide is indicated in the regular treatment of asthma where use of a combination product (long-acting β2 agonist and inhaled corticosteroid) is appropriate","accessed":"2026-08-27"},{"id":"emc_seretide_dose","url":"https://www.medicines.org.uk/emc/product/7596/smpc","label":"UK SmPC — Seretide 500 Accuhaler, section 4.2 Posology","quote":"One inhalation of 50 micrograms salmeterol and 500 micrograms fluticasone propionate twice daily … The dose should be titrated to the lowest dose at which effective control of symptoms is maintained.","accessed":"2026-08-27"},{"id":"emc_seretide_warn","url":"https://www.medicines.org.uk/emc/product/7596/smpc","label":"UK SmPC — Seretide 500 Accuhaler, section 4.4 Special warnings and precautions","quote":"Seretide Accuhaler should not be used to treat acute asthma symptoms … Rarely, Seretide may cause cardiac arrhythmias … The pharmacological side effects of β2 agonist treatment, such as tremor, palpitations and headache, have been reported","accessed":"2026-08-27"},{"id":"emc_seretide_int","url":"https://www.medicines.org.uk/emc/product/7596/smpc","label":"UK SmPC — Seretide 500 Accuhaler, section 4.5 Interactions","quote":"β adrenergic blockers may weaken or antagonise the effect of salmeterol … The concomitant administration of ketoconazole should be avoided, unless the benefits outweigh the potentially increased risk of systemic side effects of salmeterol treatment","accessed":"2026-08-27"},{"id":"fda_serevent_max","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22SEREVENT+DISKUS%22&limit=1","label":"US FDA label for SEREVENT DISKUS (salmeterol xinafoate), section 2 Dosage and Administration, via openFDA (GSK, effective 2022-10-10)","quote":"More frequent administration or a greater number of inhalations (more than 1 inhalation twice daily) is not recommended as some patients are more likely to experience adverse effects.","accessed":"2026-08-27"},{"id":"fda_serevent_boxed","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22SEREVENT+DISKUS%22&limit=1","label":"US FDA label for SEREVENT DISKUS, boxed warning and indications, via openFDA","quote":"Long-acting beta2-adrenergic agonists (LABA), such as salmeterol … as monotherapy (without inhaled corticosteroids [ICS]) increase the risk of asthma-related death … Not indicated for relief of acute bronchospasm.","accessed":"2026-08-27"},{"id":"fda_advair_max","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ADVAIR+DISKUS%22&limit=1","label":"US FDA label for ADVAIR DISKUS (fluticasone propionate and salmeterol), section 2 Dosage and Administration, via openFDA (effective 2025-08-08)","quote":"The maximum recommended dosage is ADVAIR DISKUS 500/50 twice daily.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:31.341231+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}