{"ok":true,"entry":{"slug":"sacubitril-valsartan","kind":"medication","name":"sacubitril/valsartan","aliases":["Entresto"],"brands_sg":["Entresto","Meravo"],"class":"angiotensin receptor-neprilysin inhibitor","tags":["heart-bp"],"use_for":"heart failure · sg label also lists essential hypertension","use_after":"ndf: the dose is doubled every 2–4 weeks to the target","use_duration":null,"take_with":"healthhub: with or without food","pros":["healthhub: lowers death and hospital admission risk","sg label: taken in place of an ace inhibitor or arb","two sg brands registered: entresto and meravo"],"cons":["dizziness and higher blood potassium are common","ndf lists pregnancy as a contraindication","not started until 36 hours after an ace inhibitor"],"dose_note":"the sg label for entresto states the heart-failure ceiling as \"The target dose of Entresto is 200 mg twice daily\", reached by doubling \"every 2–4 weeks\"; for essential hypertension it states that from 200 mg once daily \"the dose can be increased to 400 mg once daily\" — as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["pregnancy — ndf contraindication; healthhub asks that it be stopped as soon as pregnancy is known","an ace inhibitor taken in the last 36 hours — healthhub precaution and ndf contraindication","angioedema on a previous ace inhibitor or arb, or hereditary angioedema — ndf contraindication","egfr below 10 ml/min/1.73 m² or dialysis — ndf contraindication for lack of data"],"clashes":[{"src":["ndf_entresto_ci","hh_sacval_prec"],"note":"ndf: concomitant use is contraindicated and entresto must not be started until 36 hours after stopping the ace inhibitor","with":"ace inhibitors (enalapril, lisinopril and others)"},{"src":["ndf_entresto_dose"],"note":"ndf: should not be co-administered, because entresto already blocks the angiotensin ii receptor","with":"other angiotensin receptor blockers (arbs)"},{"src":["ndf_entresto_ci"],"note":"ndf: contraindicated in diabetes or renal impairment (egfr below 60 ml/min/1.73 m²)","with":"aliskiren-containing products"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084), Forensicclassification column; read from the cached copy at /tmp/hsa_all.json and filtered locally, not re-fetched","quote":"ENTRESTO FILM COATED TABLET 50MG/100MG/200MG (SIN14947P, SIN14948P, SIN14949P) and MERAVO FILM-COATED TABLETS 50MG/100MG/200MG (SIN16872P, SIN16873P, SIN16874P) — all 6 sacubitril/valsartan rows read Prescription Only, ATC C09DX04","accessed":"2026-08-27"},{"id":"ndf_entresto","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14947p/","label":"MOH National Drug Formulary (Singapore) — ENTRESTO FILM COATED TABLET 50MG [SIN14947P], product information","quote":"SACUBITRIL/VALSARTAN SODIUM SALT COMPLEX … Forensic Classification PRESCRIPTION ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code C09DX04 … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_entresto_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14947p/","label":"MOH National Drug Formulary (Singapore) — ENTRESTO [SIN14947P], section 3 Indications","quote":"Entresto is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II–IV) and reduced ejection fraction … Entresto is indicated for the treatment of essential hypertension.","accessed":"2026-08-27"},{"id":"ndf_entresto_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14947p/","label":"MOH National Drug Formulary (Singapore) — ENTRESTO [SIN14947P], section 4 Dosage regimen and administration","quote":"The target dose of Entresto is 200 mg twice daily … doubled every 2–4 weeks to the target dose … the dose can be increased to 400 mg once daily … Entresto should not be co-administered with an ARB","accessed":"2026-08-27"},{"id":"ndf_entresto_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14947p/","label":"MOH National Drug Formulary (Singapore) — ENTRESTO [SIN14947P], section 5 Contraindications","quote":"Concomitant use with ACE inhibitors … must not be administered until 36 hours after discontinuing ACE inhibitor therapy … Hereditary angioedema … Pregnancy … Severe renal impairment with eGFR <10 ml/min/1.73 m² and patients undergoing dialysis","accessed":"2026-08-27"},{"id":"hh_sacval","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sacubitril-valsartan","label":"HealthHub (MOH Singapore) — Sacubitril / Valsartan, medication information leaflet, uses (article last reviewed 22 May 2026)","quote":"This medication is used in the treatment of heart failure … Entresto also reduces the risk of death and hospital admission for heart failure. It is usually used with other medications to treat heart failure","accessed":"2026-08-27"},{"id":"hh_sacval_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sacubitril-valsartan","label":"HealthHub (MOH Singapore) — Sacubitril / Valsartan, administration","quote":"Do not stop taking your medication without checking with your healthcare professional. You may take this medication with or without food.","accessed":"2026-08-27"},{"id":"hh_sacval_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sacubitril-valsartan","label":"HealthHub (MOH Singapore) — Sacubitril / Valsartan, common side effects","quote":"Side effects of Entresto may include: Dizziness and lightheadedness … Increased potassium levels in your blood. Your doctor may monitor your potassium levels and kidney function when you are on this medication.","accessed":"2026-08-27"},{"id":"hh_sacval_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/sacubitril-valsartan","label":"HealthHub (MOH Singapore) — Sacubitril / Valsartan, precautions","quote":"Once you find out you are pregnant, stop the medication as soon as possible … You have taken a type of medication belonging to the drug class of Angiotensin-Converting Enzyme Inhibitors … in the last 36 hours.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}