{"ok":true,"entry":{"slug":"resveratrol","kind":"supplement","name":"resveratrol","aliases":["trans-resveratrol","Japanese knotweed extract"],"brands_sg":["California Gold Nutrition","Thorne","Life Extension","ProHealth Longevity","Doctor's Best"],"class":"polyphenol","tags":["heart","general"],"use_for":"limited human evidence — 4 of 129 outcomes rated high","use_after":null,"use_duration":null,"take_with":null,"pros":["45 systematic reviews, rated moderate-to-high quality","4 outcomes reached high-certainty grade evidence","129 human associations have been graded, not guessed"],"cons":["125 of 129 outcomes fell short of high certainty","the high-certainty findings sit in patient groups","no nih ods or nccih fact sheet exists to check it"],"dose_note":"the 2026 umbrella review states no dose in its abstract — it pools 45 systematic reviews rather than trials, so no studied amount can be quoted here without reading the underlying meta-analyses; the figures on a singapore shelf are label amounts, not studied doses (the iherb sg listing shows trans-resveratrol at 200 mg and 600 mg per capsule, and several blends where resveratrol sits with grape seed, red wine extract, nmn or quercetin)","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["the four high-certainty findings came from patients, not healthy adults","resveratrol is not listed in hsa annex a or b — hsa says that list is not exhaustive","no nih ods or nccih fact sheet was found, so no official safety page backs this entry"],"clashes":[],"sources":[{"id":"umbrella2026_scope","url":"https://europepmc.org/article/PMC/PMC13196030","label":"Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of RCTs (Nutrition Journal, Apr 2026; PMC13196030)","quote":"Forty-five systematic reviews with 129 associations between resveratrol supplementation and human health were included, which consists of 68 outcomes. Using the AMSTAR measurement tool, all articles were categorized as moderate-to-high quality.","accessed":"2026-08-27"},{"id":"umbrella2026_grade","url":"https://europepmc.org/article/PMC/PMC13196030","label":"Nutrition Journal 2026 umbrella review — GRADE certainty of the significant associations","quote":"Among 35 significant associations, four were supported by high-certainty evidence according to GRADE, including positive effects of resveratrol supplementation on reducing waist circumference … total cholesterol among overweight adults … blood pressure … among patients with type 2 diabetes","accessed":"2026-08-27"},{"id":"umbrella2026_moderate","url":"https://europepmc.org/article/PMC/PMC13196030","label":"Nutrition Journal 2026 umbrella review — what sits at moderate certainty","quote":"moderate-certainty evidence indicated that resveratrol supplementation may promote glucose metabolism, improve renal function, protect endothelial health, enhance working memory, improve hepatic steatosis, lower hormones, and reduce inflammation","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. No. 001 (October 2025), clause 1.3 + Annexes A and B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [resveratrol, Polygonum/Reynoutria/Fallopia japonica and Vitis vinifera not listed in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/resveratrol","label":"iHerb Singapore — Resveratrol category, default order (1 - 48 of 145 results)","quote":"California Gold Nutrition, Resveratrol Complex with Grape Seed Extract … trans-Resveratrol, 200 mg … Thorne, ResveraCel® … Life Extension, Optimized Resveratrol Elite™ … ProHealth Longevity, Trans-Resveratrol Plus … Doctor's Best, Trans-Resveratrol 600, 600 mg","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Thorne","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":66}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}