{"ok":true,"entry":{"slug":"quetiapine","kind":"medication","name":"quetiapine","aliases":["Seroquel"],"brands_sg":["Seroquel","Seroquel XR","Ketipinor","Quetiapine Sandoz","Apo-Quetiapine"],"class":"atypical antipsychotic","tags":["mental-health"],"use_for":"healthhub: schizophrenia, bipolar or depression symptoms","use_after":"healthhub: with or without food; xr swallowed whole","use_duration":null,"take_with":"water · healthhub: alcohol and grapefruit are avoided","pros":["healthhub: for schizophrenia and bipolar symptoms","healthhub: may be taken with or without food","hh: also used with other medicines for low mood"],"cons":["hh: drowsiness, dizziness, dry mouth, weight gain","healthhub: can worsen blood sugar control in diabetes","hh: rare movement, heart-rhythm and blood problems"],"dose_note":"the us seroquel label sets a maximum per indication in its table 1: '750 mg/day' for schizophrenia in adults, '800 mg/day' for adolescents 13–17 and for bipolar mania in adults, '600 mg/day' for bipolar mania in children 10–17, and '300 mg/day' for bipolar depression in adults. the same label notes a lower starting dose in the elderly and in hepatic impairment. sg-registered strengths run 25–400 mg as immediate-release and extended-release tablets. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["diabetes — healthhub: it may worsen blood sugar control","heart, blood, kidney, liver or thyroid conditions (healthhub)","seizures, dementia, parkinson's or past blood clots (healthhub)","under 25 — healthhub warns of new self-harm thoughts early on"],"clashes":[{"src":["hh_que_avoid"],"food":true,"note":"healthhub: it can cause excessive sleepiness","with":"alcohol"},{"src":["hh_que_avoid"],"food":true,"note":"healthhub: the amount of quetiapine in the body may be increased","with":"grapefruit juice or products"},{"src":["hh_que_precautions"],"note":"healthhub: some may affect how it works or cause serious drug interactions","with":"other medicines, supplements and traditional remedies"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 26 registered quetiapine products carry 'Prescription Only' — SEROQUEL TABLET 25/100/200/300 mg · Seroquel XR 50–400 mg · Ketipinor · Quetiapine Sandoz · APO-QUETIAPINE · SQURO XR · SAQUIN SR · EVIPSYZED","accessed":"2026-08-27"},{"id":"hh_que_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/quetiapine","label":"HealthHub (National Medication Information workgroup, SG) — Quetiapine: what is this medication for","quote":"Quetiapine belongs to a class of medications known as atypical (second-generation) antipsychotics. It is used to treat and prevent the return of symptoms in Schizophrenia and other mental health related conditions … bipolar disorder … symptoms of depression","accessed":"2026-08-27"},{"id":"hh_que_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/quetiapine","label":"HealthHub — Quetiapine: how should I take this medication","quote":"Quetiapine may be taken with or without food. If you are taking Quetiapine XR (extended-release) tablet, swallow the tablet whole. Do not split, crush or chew the tablet.","accessed":"2026-08-27"},{"id":"hh_que_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/quetiapine","label":"HealthHub — Quetiapine: common side effects","quote":"Drowsiness or feeling tired … Nausea, vomiting … Constipation … Dizziness … Dry mouth … Increase in appetite, weight gain. Most of the side effects listed here will improve with time.","accessed":"2026-08-27"},{"id":"hh_que_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/quetiapine","label":"HealthHub — Quetiapine: what precautions should I take","quote":"You have diabetes. Quetiapine may sometimes worsen blood sugar control in diabetes … Blood disorders, irregular heartbeat or heart problems; kidney, liver or thyroid disease, breast cancer, stroke … seizures (fits), dementia, history of blood clots, Parkinson's disease","accessed":"2026-08-27"},{"id":"hh_que_rare","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/quetiapine","label":"HealthHub — Quetiapine: rare but serious side effects","quote":"Confusion, high fever, severe muscle stiffness, irregular blood pressure (signs and symptoms of neuroleptic malignant syndrome) … Uncontrollable movements … (tardive dyskinesia) … prolonged QTc interval … symptoms of blood dyscrasias","accessed":"2026-08-27"},{"id":"hh_que_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/quetiapine","label":"HealthHub — Quetiapine: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking Quetiapine as it can cause excessive sleepiness. Avoid grapefruit juice/products while taking Quetiapine, as the amount of Quetiapine in the body may be increased","accessed":"2026-08-27"},{"id":"hh_que_young","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/quetiapine","label":"HealthHub — Quetiapine: important warning for people under 25","quote":"In some cases, particularly in young people below the age of 25 years, this medication may cause … New or worsening thoughts of harming yourself or ending your life; Worsening agitation, restlessness, violent behaviour","accessed":"2026-08-27"},{"id":"fda_seroquel_max","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22SEROQUEL%22&limit=1","label":"US FDA label for SEROQUEL (quetiapine fumarate), Table 1 Recommended Dosing, via openFDA (AstraZeneca, effective 2025-01-22)","quote":"Indication Initial Dose Recommended Dose Maximum Dose Schizophrenia - Adults 25 mg twice daily 150-750 mg/day 750 mg/day Schizophrenia - Adolescents (13-17 years) 25 mg twice daily 400-800 mg/day 800 mg/day","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}