{"ok":true,"entry":{"slug":"progesterone","kind":"medication","name":"progesterone","aliases":["micronised progesterone","Utrogestan"],"brands_sg":["Crinone","Cyclogest","Utrogestan","Endometrin","Injesta"],"class":"progestogen","tags":["hormonal"],"use_for":"sg label: progesterone-deficit disorders; hrt with estrogen","use_after":"nhs (hrt): often days 15–26 of a 28-day cycle","use_duration":null,"take_with":"nhs: at bedtime, at least 2 hours after food, with water","pros":["sg label: 100 mg and 200 mg capsules registered in sg","sg label: vaginal route is an alternative to oral","nhs: one extra dose is unlikely to harm you"],"cons":["sg label: contraindicated in thromboembolic disorders","sg label: not for undiagnosed vaginal bleeding","nhs: st john's wort may stop it working as well"],"dose_note":"the sg utrogestan insert (sin15475p) states the ordinary range and the ceiling separately: \"on the average for progesterone deficiencies, the daily dose is 200mg to 300 mg divided into one or two intakes, 100mg in the morning or 200mg at bedtime\", and \"in some cases, notably to help pregnancy, the doctor may increase the dose to 600 mg per day, divided into three intakes\" — 600 mg/day is the highest figure the sg label prints for oral use. the same insert gives \"200mg–400mg per day\" for threatened abortion and, for menace of preterm delivery, \"400 mg every 6 to 8 hours depending on the clinical response during the acute phase then a dosage of 3 x 200mg /day as maintenance\". the uk nhs hrt figure is lower: \"the usual dose of utrogestan is 2 capsules (200mg) taken once a day, on days 15 to 26 of your 28-day hrt cycle\". as directed on the label or by your doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["severe liver dysfunction — an sg label contraindication","undiagnosed vaginal bleeding — an sg label contraindication","thromboembolic or thrombophlebitis disorders — an sg label contraindication","breast or genital tract carcinoma — an sg label contraindication"],"clashes":[{"src":["nhs_utro_int"],"note":"nhs lists these among medicines that may affect how utrogestan works","with":"epilepsy medicines such as phenytoin or carbamazepine"},{"src":["nhs_utro_int"],"note":"nhs lists tb and hiv medicines among those that may affect how utrogestan works","with":"rifampicin (tuberculosis) and ritonavir (hiv)"},{"src":["nhs_utro_int"],"note":"nhs: st john's wort may stop utrogestan from working as well","with":"st john's wort"},{"src":["nhs_utro_int"],"note":"nhs lists antifungal medicines among those that may affect how utrogestan works","with":"antifungals such as ketoconazole or terbinafine"},{"src":["nhs_utro_int"],"note":"nhs lists ciclosporin and warfarin among medicines to declare before starting","with":"ciclosporin and warfarin"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 27 Aug 2026","quote":"CRINONE VAGINAL GEL 8% SIN10884P; CYCLOGEST PESSARY 400 mg SIN03626P; UTROGESTAN CAPSULE 200mg SIN15475P; UTROGESTAN 100 mg SIN11437P; ENDOMETRIN 100 MG SIN15005P; INJESTA 100/200MG — ATC G03DA04, all 7 progesterone rows Prescription Only","accessed":"2026-08-27"},{"id":"ndf_utrogestan","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15475p/","label":"MOH National Drug Formulary (Singapore) — UTROGESTAN CAPSULE 200MG [SIN15475P], product information","quote":"MICRONISED PROGESTERONE - 200 MG … Registration Number SIN15475P … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code G03DA04 … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_utro_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15475p/","label":"MOH National Drug Formulary (Singapore) — UTROGESTAN [SIN15475P], Indication","quote":"Disorders related to progesterone deficit … therapy of menopause (adjunctive use with estrogen in post-menopausal women for prevention of endometrial hyperplasia) … the vaginal route represents an alternative to the oral route","accessed":"2026-08-27"},{"id":"ndf_utro_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15475p/","label":"MOH National Drug Formulary (Singapore) — UTROGESTAN [SIN15475P], Recommended Dosage","quote":"the daily dose is 200mg to 300 mg divided into one or two intakes … In some cases, notably to help pregnancy, the doctor may increase the dose to 600 mg per day, divided into three intakes","accessed":"2026-08-27"},{"id":"ndf_utro_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15475p/","label":"MOH National Drug Formulary (Singapore) — UTROGESTAN [SIN15475P], Contraindications","quote":"Severe hepatic dysfunction. Undiagnosed vaginal bleeding. Known missed abortion or ectopic pregnancy. Mammary or genital tract carcinoma. Thromboembolic or thrombophlebitis disorders. Cerebral haemorrhage. Porphyria","accessed":"2026-08-27"},{"id":"nhs_utro_how","url":"https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/utrogestan-micronised-progesterone/how-and-when-to-take-utrogestan/","label":"NHS medicines A–Z — Utrogestan (micronised progesterone), how and when to take it (reviewed 2026)","quote":"The usual dose of Utrogestan is 2 capsules (200mg) taken once a day, on days 15 to 26 of your 28-day HRT cycle … Take Utrogestan at bedtime, at least 2 hours after food","accessed":"2026-08-27"},{"id":"nhs_utro_extra","url":"https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/utrogestan-micronised-progesterone/how-and-when-to-take-utrogestan/","label":"NHS medicines A–Z — Utrogestan (micronised progesterone), if you take too much","quote":"Taking an extra dose of Utrogestan is unlikely to harm you. You may feel drowsy, dizzy, sleepy or tired","accessed":"2026-08-27"},{"id":"nhs_utro_int","url":"https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/utrogestan-micronised-progesterone/taking-utrogestan-with-other-medicines-and-herbal-supplements/","label":"NHS medicines A–Z — Taking Utrogestan with other medicines and herbal supplements","quote":"epilepsy medicines such as phenytoin or carbamazepine … medicines for HIV, such as ritonavir … rifampicin … ciclosporin … antifungal medicines such as ketoconazole or terbinafine … warfarin … St John's wort may stop Utrogestan from working as well","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}