{"ok":true,"entry":{"slug":"pregabalin","kind":"medication","name":"pregabalin","aliases":["Lyrica"],"brands_sg":["Lyrica","Regadex","Epibalin","Prega","Rewisca"],"class":"anticonvulsant / neuropathic agent","tags":["other","pain-fever"],"use_for":"prescribed for seizures, nerve pain or anxiety","use_after":"healthhub: with or without food, capsule swallowed whole","use_duration":null,"take_with":"water · healthhub: alcohol can cause excessive drowsiness","pros":["healthhub: for nerve pain as well as seizures","healthhub: with or without food","nhs: usually safe with other medicines"],"cons":["healthhub: dizziness, drowsiness, unsteady walking","healthhub: rare mood or behaviour changes early on","healthhub: abrupt stopping may worsen the condition"],"dose_note":"the us fda label for lyrica gives the adult ceiling as 'Adults (17 years and older) 150 mg/day 600 mg/day 2 or 3 divided doses' — 600 mg/day is the recommended maximum dosage, and the same label caps some indications lower: for diabetic peripheral neuropathy pain 'The maximum recommended dose of LYRICA is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min', and for fibromyalgia 'Maximum dose of 450 mg/day'. it also says the dose should be adjusted in adults with reduced renal function. sg-registered capsules run 25, 50, 75, 100, 150 and 300 mg. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["liver, kidney or heart problems (healthhub)","diabetes, or a history of alcohol or drug dependence (healthhub)","pregnancy or breastfeeding — healthhub: discuss with your doctor","driving or machinery — healthhub: may cause drowsiness or dizziness"],"clashes":[{"src":["hh_pre_avoid"],"food":true,"note":"healthhub: it can cause excessive drowsiness","with":"alcohol"},{"src":["nhs_pre_mix"],"note":"nhs lists these among medicines to tell a doctor about before starting","with":"strong opioid painkillers (morphine, codeine, oxycodone)"},{"src":["nhs_pre_mix"],"note":"nhs: pregabalin can make these side effects worse","with":"medicines that cause sleepiness or dizziness"},{"src":["nhs_pre_mix"],"note":"nhs: not enough information to say they are always safe with pregabalin","with":"herbal remedies and supplements"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 63 registered pregabalin products carry Forensicclassification 'Prescription Only' — SIN13094P Lyrica Capsule 25mg · SIN15775P REGADEX · SIN15724P EPIBALIN · SIN16317P PREGA · SIN15655P REWISCA; strengths 25 mg to 300 mg","accessed":"2026-08-27"},{"id":"hh_pre_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pregabalin","label":"HealthHub (National Medication Information workgroup, SG) — Pregabalin: what is this medication for","quote":"Pregabalin is used to control seizures (fits) and other conditions related to the nervous system. It can also be used for neuropathic (nerve) pain.","accessed":"2026-08-27"},{"id":"hh_pre_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pregabalin","label":"HealthHub — Pregabalin: how should I take this medication","quote":"You can take this medication with or without food. Swallow the capsule whole with water … Stopping your medication without informing your healthcare professional may cause your condition to worsen quickly.","accessed":"2026-08-27"},{"id":"hh_pre_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pregabalin","label":"HealthHub — Pregabalin: common side effects","quote":"The common side effects of Pregabalin include: Dizziness, drowsiness, fatigue, unsteadiness in walking … Blurred vision … Constipation … Dry mouth … Nausea, vomiting … Headache … Increased appetite … Swelling of the body","accessed":"2026-08-27"},{"id":"hh_pre_serious","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pregabalin","label":"HealthHub — Pregabalin: rare but serious side effects","quote":"In rare cases, this medication may cause the following changes to a person's mental condition, especially in the first few weeks of treatment or during dose changes: Worsening agitation, restlessness, violent behaviour","accessed":"2026-08-27"},{"id":"hh_pre_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pregabalin","label":"HealthHub — Pregabalin: what precautions should I take","quote":"Liver, kidney, heart problems; Diabetes; History of alcoholism; History of drug dependence or abuse; Drug allergies … Be careful when driving or operating machinery as this medication may cause drowsiness or dizziness.","accessed":"2026-08-27"},{"id":"hh_pre_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pregabalin","label":"HealthHub — Pregabalin: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking this medication as it can cause excessive drowsiness.","accessed":"2026-08-27"},{"id":"nhs_pre_about","url":"https://www.nhs.uk/medicines/pregabalin/","label":"NHS Medicines A-Z — Pregabalin (index page)","quote":"Pregabalin - Brand names: Alzain, Axalid, Lyrica, Misabri. Find out how pregabalin treats epilepsy, anxiety and nerve pain and how to take it.","accessed":"2026-08-27"},{"id":"nhs_pre_mix","url":"https://www.nhs.uk/medicines/pregabalin/taking-pregabalin-with-other-medicines-and-herbal-supplements/","label":"NHS Medicines A-Z — Taking pregabalin with other medicines and herbal supplements","quote":"It's usually safe to take pregabalin with other medicines … strong opioid painkillers such as morphine, codeine or oxycodone; medicines that make you feel sleepy or dizzy – pregabalin can make these side effects worse","accessed":"2026-08-27"},{"id":"fda_lyrica_adult","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22LYRICA%22&limit=1","label":"US FDA label for LYRICA (pregabalin), section 2 Dosage and Administration, via openFDA (Parke-Davis/Pfizer, effective 2020-06-15)","quote":"Recommended Dosage for Adults and Pediatric Patients 1 Month and Older … Recommended Initial Dosage Recommended Maximum Dosage … Adults (17 years and older) 150 mg/day 600 mg/day 2 or 3 divided doses","accessed":"2026-08-27"},{"id":"fda_lyrica_dpn","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22LYRICA%22&limit=1","label":"US FDA label for LYRICA, section 2.2 Neuropathic Pain Associated with Diabetic Peripheral Neuropathy in Adults, via openFDA","quote":"The maximum recommended dose of LYRICA is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min.","accessed":"2026-08-27"},{"id":"fda_lyrica_table","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22LYRICA%22&limit=1","label":"US FDA label for LYRICA, Highlights dosing-recommendations table, via openFDA","quote":"Dosing recommendations: INDICATION Dosing Regimen Maximum Dose … PHN 2 or 3 divided doses per day 300 mg/day within 1 week. Maximum dose of 600 mg/day … Fibromyalgia … Maximum dose of 450 mg/day.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}