{"ok":true,"entry":{"slug":"pravastatin","kind":"medication","name":"pravastatin","aliases":["Pravachol"],"brands_sg":["Apo-Pravastatin"],"class":"statin","tags":["heart-bp"],"use_for":"prescribed for high cholesterol — a doctor decides","use_after":"nhs: once a day, usually in the evening; food optional","use_duration":null,"take_with":"water · healthhub: red yeast rice raises side-effect risk","pros":["healthhub: may reduce heart attack and stroke risk","nhs: once a day, with or without food","nhs: usually taken long term, sometimes for life"],"cons":["nhs: headache, dizziness, nausea, muscle aches","nhs: rare liver, pancreas or muscle damage","nhs: not recommended during pregnancy"],"dose_note":"the us fda label for pravastatin sodium tablets states 'The recommended starting dosage is pravastatin sodium tablets 40 mg to 80 mg once daily' and, above that, directs prescribers to 'prescribe alternative LDL-C-lowering treatment' for patients 'unable to achieve their LDL-C goal receiving pravastatin sodium tablets 80 mg daily' — 80 mg once daily is the highest adult dosage the label names, and the label states no general adult maximum. its only explicit maxima are narrower: 'The maximum recommended dosage of pravastatin sodium tablets in patients with severe renal impairment is 40 mg once daily' and, with cyclosporine, 20 mg once daily. only 10 mg and 20 mg single-ingredient tablets are registered in singapore. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["liver or kidney problems, or an underactive thyroid (nhs)","pregnancy or planning one — nhs: not recommended","a muscle condition such as myasthenia gravis, or a past brain bleed (nhs)","regularly drinking a lot of alcohol (nhs · healthhub: under 3 drinks a day)"],"clashes":[{"src":["hh_pra_avoid"],"note":"healthhub: this supplement may increase the risk of side-effects","with":"red yeast rice"},{"src":["hh_pra_avoid","nhs_pra_food"],"food":true,"note":"healthhub: limit to less than 3 drinks a day; nhs: too much raises the risk of liver problems","with":"alcohol"},{"src":["hh_pra_avoid","nhs_pra_mix"],"note":"healthhub and nhs both list these antibiotics as affecting statin side-effect risk","with":"clarithromycin, erythromycin, fusidic acid"},{"src":["hh_pra_avoid","nhs_pra_mix"],"note":"healthhub and nhs both list antifungals among medicines that may not mix well","with":"itraconazole, fluconazole, ketoconazole"},{"src":["nhs_pra_mix","hh_pra_avoid"],"note":"nhs and healthhub list these among medicines that may not mix well with pravastatin","with":"ciclosporin, warfarin, fibrates, colchicine, rifampicin, hiv and hepatitis c medicines"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 3 registered pravastatin products carry Forensicclassification 'Prescription Only' — SIN12671P APO-PRAVASTATIN TABLET 10 mg · SIN12670P APO-PRAVASTATIN TABLET 20 mg · SIN14508P PRAVAFEN (fenofibrate 160mg + pravastatin 40mg). No PRAVACHOL row exists.","accessed":"2026-08-27"},{"id":"nhs_pra_about","url":"https://www.nhs.uk/medicines/pravastatin/","label":"NHS Medicines A-Z — Pravastatin: what pravastatin is for","quote":"Pravastatin is a medicine used to treat high cholesterol and prevent heart attacks and strokes. It's only available with a prescription … a type of cholesterol-lowering medicine called a statin.","accessed":"2026-08-27"},{"id":"nhs_pra_howto","url":"https://www.nhs.uk/medicines/pravastatin/","label":"NHS Medicines A-Z — Pravastatin: how to take pravastatin","quote":"try to take it at the same time each day – usually in the evening; you can take it with or without food … You usually need to take pravastatin for a long time, sometimes for life.","accessed":"2026-08-27"},{"id":"nhs_pra_side","url":"https://www.nhs.uk/medicines/pravastatin/","label":"NHS Medicines A-Z — Pravastatin: side effects","quote":"Common side effects of pravastatin include: headache; dizziness; feeling sick (nausea); digestive problems … muscle aches; sleep problems … Possible serious side effects … hepatitis … acute pancreatitis … damage to the muscles","accessed":"2026-08-27"},{"id":"nhs_pra_who","url":"https://www.nhs.uk/medicines/pravastatin/","label":"NHS Medicines A-Z — Pravastatin: who can and cannot take it, and pregnancy","quote":"you have liver or kidney problems; you have an underactive thyroid … myasthenia gravis; you've had a bleed in the brain; you regularly drink a lot of alcohol … Pravastatin is not recommended during pregnancy","accessed":"2026-08-27"},{"id":"nhs_pra_mix","url":"https://www.nhs.uk/medicines/pravastatin/","label":"NHS Medicines A-Z — Taking pravastatin with other medicines, food and drink","quote":"fibrates such as bezafibrate; some antifungal medicines, such as itraconazole or fluconazole; some antibiotics such as fusidic acid, erythromycin or clarithromycin; medicines for viral infections including HIV and hepatitis C; ciclosporin … colchicine … rifampicin","accessed":"2026-08-27"},{"id":"nhs_pra_food","url":"https://www.nhs.uk/medicines/pravastatin/","label":"NHS Medicines A-Z — Pravastatin: food, drink and alcohol","quote":"You can eat as normal while taking pravastatin. Try to limit how much alcohol you drink while taking pravastatin, as it can increase the risk of side effects like liver problems.","accessed":"2026-08-27"},{"id":"hh_pra_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pravastatin","label":"HealthHub (Singapore) — Pravastatin: what is this medication for","quote":"Statins lower the amount of 'bad cholesterol' … High 'bad cholesterol' levels can cause your blood vessels to clog up … Hence, statins may reduce your risk for heart attack and stroke.","accessed":"2026-08-27"},{"id":"hh_pra_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pravastatin","label":"HealthHub — Pravastatin: what food or medication should I avoid","quote":"Avoid taking a supplement called red yeast rice as this supplement may increase the risk of side-effects. Avoid or limit drinking alcohol to less than 3 drinks a day … Warfarin … clarithromycin, erythromycin … itraconazole, ketoconazole","accessed":"2026-08-27"},{"id":"fda_prava_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22PRAVASTATIN+SODIUM%22&limit=5","label":"US FDA label for pravastatin sodium tablets, section 2 Dosage and Administration, via openFDA (Preferred Pharmaceuticals, effective 2026-08-17)","quote":"The recommended starting dosage is pravastatin sodium tablets 40 mg to 80 mg once daily … For patients … unable to achieve their LDL-C goal receiving pravastatin sodium tablets 80 mg daily, prescribe alternative LDL-C-lowering treatment.","accessed":"2026-08-27"},{"id":"fda_prava_max","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22PRAVASTATIN+SODIUM%22&limit=5","label":"US FDA label for pravastatin sodium tablets, sections 2.4 Renal Impairment and 2.5 Drug Interactions, via openFDA","quote":"The maximum recommended dosage of pravastatin sodium tablets in patients with severe renal impairment is 40 mg once daily … The maximum recommended dosage of pravastatin sodium tablets in patients taking cyclosporine is 20 mg once daily.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:29.426925+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}