{"ok":true,"entry":{"slug":"pomegranate","kind":"supplement","name":"pomegranate","aliases":["Punica granatum","punicalagin","ellagic acid"],"brands_sg":["Source Naturals","Life Extension","Thorne","Navitas Organics","Swanson Vitamins"],"class":"botanical","tags":["heart","skin-hair"],"use_for":"blood-pressure and glucose signals; one 4-week skin trial","use_after":null,"use_duration":"the skin trial ran four weeks","take_with":null,"pros":["nccih: juice or extract may reduce blood pressure","nccih: a small reduction in blood glucose is reported","a 4-week rct cut wrinkle severity against placebo"],"cons":["nccih: more research is needed to confirm the bp effect","no clear effect on cholesterol or other lipids","hsa prohibits stem bark and root bark in supplements"],"dose_note":"nccih notes many of the studies used pomegranate juice rather than dietary supplements, and gives no dose; the wrinkle trial gave a standardised punicalagin-enriched oral extract daily for four weeks; singapore listings run 500 mg extract tablets, softgels and whole-fruit powders","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["root, stem and peel may not be safe in large amounts — nccih","allergic reactions to pomegranate have been reported","pregnant or nursing — only the juice is described as likely safe","hsa: punica granatum stem bark and root bark are prohibited in hs"],"clashes":[],"sources":[{"id":"nccih_pomegranate","url":"https://www.nccih.nih.gov/health/pomegranate/at-a-glance","label":"NCCIH — Pomegranate: What You Need To Know (last updated April 2025)","quote":"Pomegranate juice or extract may be helpful in reducing blood pressure, but additional research is needed … may reduce blood glucose levels to a small extent … no clear effects have been demonstrated [on lipids]","accessed":"2026-08-27"},{"id":"chakkalakal2022","url":"https://europepmc.org/article/PMC/PMC9699032","label":"Prospective Randomized Double-Blind Placebo-Controlled Study of Oral Pomegranate Extract on Skin Wrinkles, Biophysical Features, and the Gut-Skin Axis (Chakkalakal et al., J Clin Med 2022)","quote":"Subjects were supplemented with a standardized punicalagin enriched oral pomegranate extract … or a placebo … daily for four weeks … The PE group had significant reductions in wrinkle severity (p < 0.01)","accessed":"2026-08-27"},{"id":"hsa_annex","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A and Annex B — read from the cached PDF text on disk","quote":"87. Punica granatum (stem bark and root bark) — Prohibited in HS — Absence of pomegranate alkaloids … Restricted use in TM: \"Not suitable for long term use. Seek medical advice if needed.\"","accessed":"2026-08-27"},{"id":"hsa_tables","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines, GL-CHPB-3-001 Rev. No. 020 (January 2026), Tables 4 and 5 (vitamins and minerals limits) — read from the cached PDF text on disk","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_table6","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (January 2026), Table 6: examples of diseases/conditions/disorders not allowed for health supplements","quote":"Blood and circulatory system: Hypertension, stroke, cholesterol disorders, reduces cholesterol … Endocrine system: Diabetes … Skin, hair and nails: … pigmentation disorders, alopecia","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/pomegranate","label":"iHerb Singapore — Pomegranate Extract category (default order, 1 - 28 of 28 results)","quote":"Source Naturals, Pomegranate Extract, 500 mg, 240 Tablets … Life Extension, Pomegranate Complete … Thorne, Hormone Advantage … Life Extension, Pomegranate Fruit Extract … Navitas Organics, Organic Pomegranate Powder … Swanson Vitamins, Full Spectrum Pomegranate","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Thorne","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":66}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}