{"ok":true,"entry":{"slug":"pioglitazone","kind":"medication","name":"pioglitazone","aliases":["Actos"],"brands_sg":["Actos","Deculin"],"class":"thiazolidinedione","tags":["diabetes"],"use_for":"type 2 diabetes — healthhub: helps bring blood sugar down","use_after":"once a day, at any time — sg label: with or without food","use_duration":null,"take_with":"food optional · alcohol can push blood sugar too low","pros":["healthhub: makes the body more responsive to insulin","once daily, with or without food","sg label: works alongside metformin or a sulphonylurea"],"cons":["leg swelling and weight gain are common","heart failure — the sg label bars it in any stage","bladder cancer history — the sg label bars it"],"dose_note":"the sg actos label is initiated \"at 15 mg or 30mg once daily\" and states that \"The dose may be increased to up to a maximum dose of 45 mg once daily\", adding that \"The dose of actos should not exceed 45 mg once daily in monotherapy or in combination with metformin or sulphonylurea\"; the strengths registered here are 15 mg and 30 mg only — as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["heart failure or fluid build-up — healthhub precaution, and a contraindication on the sg label","liver problems — healthhub precaution, and a contraindication on the sg label","a history of bladder cancer, or blood in the urine — healthhub precaution, and a contraindication on the sg label","macular edema or a history of fractures — healthhub precaution"],"clashes":[{"src":["ndf_actos30_insulin"],"note":"the sg actos label: contraindicated for use in combination with insulin","with":"insulin"},{"src":["ndf_actos30_combo"],"note":"sg label: if hypoglycaemia is reported, the dose of the partner drug should be decreased","with":"metformin or a sulphonylurea"},{"src":["hh_pioglitazone_food"],"food":true,"note":"healthhub: may increase the risk of having low blood sugar","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084), Forensicclassification column; cached at /tmp/hsa_all.json and filtered locally, not re-fetched","quote":"ACTOS TABLET 15 mg SIN12441P · ACTOS TABLET 30 mg SIN12442P · DECULIN TABLET 30MG SIN16882P | PIOGLITAZONE HYDROCHLORIDE EQV PIOGLITAZONE | Prescription Only | A10BG03 — the only 3 pioglitazone rows in the register","accessed":"2026-08-27"},{"id":"ndf_actos30","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12442p/","label":"MOH National Drug Formulary (Singapore) — ACTOS TABLET 30 MG [SIN12442P], product information","quote":"ACTOS TABLET 30 MG [SIN12442P] … PIOGLITAZONE HYDROCHLORIDE EQV PIOGLITAZONE - 30 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code A10BG03 … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_actos30_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12442p/","label":"MOH National Drug Formulary (Singapore) — ACTOS TABLET 30 MG [SIN12442P], Indications and Usage","quote":"actos® is indicated as oral monotherapy in type 2 diabetes mellitus patients, particularly overweight patients, inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance.","accessed":"2026-08-27"},{"id":"ndf_actos30_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12442p/","label":"MOH National Drug Formulary (Singapore) — ACTOS TABLET 30 MG [SIN12442P], Dosage in Adults","quote":"actos® may be initiated at 15 mg or 30mg once daily. The dose may be increased to up to a maximum dose of 45 mg once daily.","accessed":"2026-08-27"},{"id":"ndf_actos30_dose2","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12442p/","label":"MOH National Drug Formulary (Singapore) — ACTOS TABLET 30 MG [SIN12442P], Dosage: absolute ceiling","quote":"The dose of actos® should not exceed 45 mg once daily in monotherapy or in combination with metformin or sulphonylurea.","accessed":"2026-08-27"},{"id":"ndf_actos30_combo","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12442p/","label":"MOH National Drug Formulary (Singapore) — ACTOS TABLET 30 MG [SIN12442P], Dosage: combination therapy","quote":"In combination with metformin, the current metformin dose can be continued upon initiation of pioglitazone therapy. If patients report hypoglycaemia, the dose of metformin should be decreased.","accessed":"2026-08-27"},{"id":"ndf_actos30_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12442p/","label":"MOH National Drug Formulary (Singapore) — ACTOS TABLET 30 MG [SIN12442P], Contraindications","quote":"actos is contraindicated in patients with the following conditions … cardiac failure or history of cardiac failure (NYHA stages I to IV) … hepatic impairment … active or history of bladder cancer … uninvestigated macroscopic haematuria","accessed":"2026-08-27"},{"id":"ndf_actos30_insulin","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12442p/","label":"MOH National Drug Formulary (Singapore) — ACTOS TABLET 30 MG [SIN12442P], Contraindications: insulin","quote":"actos is also contraindicated for use in combination with insulin.","accessed":"2026-08-27"},{"id":"hh_pioglitazone","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pioglitazone","label":"HealthHub (MOH Singapore) — Pioglitazone, medication information leaflet, last reviewed 26 June 2023","quote":"It is used to control diabetes and helps to bring your blood sugar levels down by making your body more sensitive and responsive to the effects of insulin.","accessed":"2026-08-27"},{"id":"hh_pioglitazone_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pioglitazone","label":"HealthHub (MOH Singapore) — Pioglitazone, how to take it","quote":"This medication is taken once a day. You may take this medication before food or after food.","accessed":"2026-08-27"},{"id":"hh_pioglitazone_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pioglitazone","label":"HealthHub (MOH Singapore) — Pioglitazone, common side effects","quote":"The common side effects of Pioglitazone include … Leg swelling … Headache … Inflammation of the sinus and infection of the airways … Sore throat … Weight gain","accessed":"2026-08-27"},{"id":"hh_pioglitazone_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pioglitazone","label":"HealthHub (MOH Singapore) — Pioglitazone, precautions","quote":"Have heart failure (a condition in which your heart is not pumping as well as it should be) … Have a build-up of fluid in your body … Have liver problems","accessed":"2026-08-27"},{"id":"hh_pioglitazone_prec2","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pioglitazone","label":"HealthHub (MOH Singapore) — Pioglitazone, precautions: eye, bladder and bone history","quote":"Have a special type of eye disease associated with diabetes, called macular edema … Have a history of bladder cancer … Have a history of fractures","accessed":"2026-08-27"},{"id":"hh_pioglitazone_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pioglitazone","label":"HealthHub (MOH Singapore) — Pioglitazone, food and medication to avoid","quote":"Avoid taking alcohol with this medication as this may increase your risk of having low blood sugar.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}