{"ok":true,"entry":{"slug":"phenylephrine","kind":"medication","name":"phenylephrine","aliases":["Sudafed PE"],"brands_sg":["Panadol Cold Relief PE","Decolgen","Ricoflu","Uniflu","Maxigesic PE"],"class":"decongestant","tags":["cold-flu"],"use_for":"sg label: blocked nose, fever and aches in colds and flu","use_after":"sg label: 2 caplets every 4–6 hours, up to 8 a day","use_duration":null,"take_with":"sg label: water · not with other cough or cold medicines","pros":["hsa: 11 of 16 sg products are general sale list","fda: the proposed order is about effect, not safety","sg label: paired with paracetamol for fever and aches"],"cons":["fda 2024: proposed removing oral pe as not effective","us otc label: not with an maoi, or 2 weeks after","sg label: no more than 8 caplets a day, 5 days"],"dose_note":"the singapore label maximum, from the moh national drug formulary page for PANADOL COLD RELIEF PE CAPLET [SIN13878P] (paracetamol 500 mg with phenylephrine hydrochloride 5 mg), reads \"Adults (including the elderly) and children aged 12 years and over: Take 2 caplets with water, every 4 to 6 hours as needed. Do not take more than 8 caplets per day\", with \"If symptoms persist after 5 days, seek medical advice\" and \"Children under 12 years: Not recommended, except on the advice of a doctor.\" for phenylephrine on its own, the us otc drug facts label for Sudafed PE Sinus Congestion (phenylephrine HCl 10 mg per tablet) reads \"adults and children 12 years and over take 1 tablet every 4 hours; do not take more than 6 tablets in 24 hours\" — that product is not registered in singapore. the fda proposed in november 2024 to remove oral phenylephrine from the otc monograph on effectiveness grounds. the pharmacist or doctor sets the dose.","dosage":null,"ul_status":null,"sg_class":"general-sale","cautions":["heart disease, high blood pressure, thyroid disease or diabetes (us otc label)","trouble urinating from an enlarged prostate (us otc label)","pregnancy — nhs: only if a healthcare professional says so","children under 6 — nhs: decongestants should not be given to them"],"clashes":[{"src":["ndf_panadolpe_contra","fda_sudafedpe_donotuse"],"note":"sg label and us otc label: not while taking one, nor for two weeks after stopping it","with":"monoamine oxidase inhibitors (maois)"},{"src":["ndf_panadolpe_mix"],"note":"sg label: the sg packs pair phenylephrine with paracetamol, so a second paracetamol product doubles the dose","with":"other medicines containing paracetamol"},{"src":["ndf_panadolpe_mix","nhs_dec_mix"],"note":"sg label and nhs: one blocked-nose medicine at a time, sprays and tablets included","with":"other cough, cold or blocked-nose medicines"},{"src":["nhs_dec_mix"],"note":"nhs: taken with decongestants they can cause a dangerous rise in blood pressure","with":"some antidepressants"},{"src":["ndf_panadolpe_dur"],"food":true,"note":"sg label for the paracetamol combination advises against alcohol with this medicine","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (never re-fetched), 16 phenylephrine rows, 11 General Sale List / 1 Pharmacy Only / 4 Prescription Only, 27 Aug 2026","quote":"Panadol Cold Relief PE, Panadol Sinus MAX, Panadol FluMax, RICOFLU, UNIFLU, DECOLGEN NON DROWSE and MAXIGESIC PE read \"General Sale List\"; DECOLGEN COLD & FLU EXTRA STRENGTH reads \"Pharmacy Only\"; MINIMS eye drops and PHENYLALPHA injections read \"Prescription Only\"","accessed":"2026-08-27"},{"id":"ndf_panadolpe_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13878p/","label":"MOH National Drug Formulary — PANADOL COLD RELIEF PE CAPLET [SIN13878P], Product information block","quote":"PARACETAMOL - 500 MG; PHENYLEPHRINE HCL - 5 MG … Forensic Classification: GENERAL SALE LIST · Anatomical Therapeutic Chemical (ATC) code N02BE51","accessed":"2026-08-27"},{"id":"ndf_panadolpe_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13878p/","label":"MOH National Drug Formulary — PANADOL COLD RELIEF PE CAPLET [SIN13878P], What is it used for","quote":"For fast and effective relief of cold and flu symptoms such as: Blocked nose; Fever; Body aches or other associated pains","accessed":"2026-08-27"},{"id":"ndf_panadolpe_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13878p/","label":"MOH National Drug Formulary — PANADOL COLD RELIEF PE CAPLET [SIN13878P], How to use","quote":"Adults (including the elderly) and children aged 12 years and over: Take 2 caplets with water, every 4 to 6 hours as needed. Do not take more than 8 caplets per day.","accessed":"2026-08-27"},{"id":"ndf_panadolpe_dur","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13878p/","label":"MOH National Drug Formulary — PANADOL COLD RELIEF PE CAPLET [SIN13878P], How to use (duration, children, alcohol)","quote":"If symptoms persist after 5 days, seek medical advice. Children under 12 years: Not recommended, except on the advice of a doctor. Avoid taking alcohol with this medicine.","accessed":"2026-08-27"},{"id":"ndf_panadolpe_mix","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13878p/","label":"MOH National Drug Formulary — PANADOL COLD RELIEF PE CAPLET [SIN13878P], How to use (combination warnings)","quote":"Do not take with any other medicines for the relief of cough and colds, congestion or blocked nose. Do not use this medicine if you are taking … any other … medicines containing paracetamol","accessed":"2026-08-27"},{"id":"ndf_panadolpe_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin13878p/","label":"MOH National Drug Formulary — PANADOL COLD RELIEF PE CAPLET [SIN13878P], Contraindications","quote":"You are allergic to Paracetamol, Phenylephrine Hydrochloride or any of the other ingredients … You are taking or have taken in the past two weeks drugs called Monoamine Oxidase Inhibitors (MAOI's)","accessed":"2026-08-27"},{"id":"fda_sudafedpe_purpose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ca08917-1a75-4365-8520-c083e6a4225a","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Sudafed PE Sinus Congestion, phenylephrine HCl 10 mg, Purpose and Uses","quote":"Purpose: Nasal decongestant. Uses: temporarily relieves sinus congestion and pressure; temporarily relieves nasal congestion due to the common cold, hay fever or other upper respiratory allergies","accessed":"2026-08-27"},{"id":"fda_sudafedpe_dose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ca08917-1a75-4365-8520-c083e6a4225a","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Sudafed PE Sinus Congestion, Active ingredient and Directions","quote":"Active ingredient (in each tablet) Phenylephrine HCl 10 mg … adults and children 12 years and over take 1 tablet every 4 hours; do not take more than 6 tablets in 24 hours","accessed":"2026-08-27"},{"id":"fda_sudafedpe_warn","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ca08917-1a75-4365-8520-c083e6a4225a","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Sudafed PE Sinus Congestion, Warnings","quote":"Ask a doctor before use if you have heart disease; high blood pressure; thyroid disease; diabetes; trouble urinating due to an enlarged prostate gland … Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur","accessed":"2026-08-27"},{"id":"fda_sudafedpe_donotuse","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ca08917-1a75-4365-8520-c083e6a4225a","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Sudafed PE Sinus Congestion, Do not use","quote":"Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) … or for 2 weeks after stopping the MAOI drug.","accessed":"2026-08-27"},{"id":"fda_pe_order","url":"https://www.fda.gov/news-events/press-announcements/fda-proposes-ending-use-oral-phenylephrine-otc-monograph-nasal-decongestant-active-ingredient-after","label":"US FDA news release, 7 November 2024 — FDA Proposes Ending Use of Oral Phenylephrine as OTC Monograph Nasal Decongestant Active Ingredient After Extensive Review","quote":"proposing to remove oral phenylephrine as an active ingredient that can be used in over-the-counter (OTC) monograph drug products for the temporary relief of nasal congestion … oral phenylephrine is not effective for this use","accessed":"2026-08-27"},{"id":"fda_pe_order2","url":"https://www.fda.gov/news-events/press-announcements/fda-proposes-ending-use-oral-phenylephrine-otc-monograph-nasal-decongestant-active-ingredient-after","label":"US FDA news release, 7 November 2024 — status of the proposed order","quote":"For now, companies may continue to market OTC monograph drug products containing oral phenylephrine … This is a proposed order. Only a final order will affect what products can be marketed … based on effectiveness concerns, not on safety concerns.","accessed":"2026-08-27"},{"id":"nhs_dec_about","url":"https://www.nhs.uk/conditions/decongestants/","label":"NHS — Decongestants (conditions A–Z), what they are","quote":"Decongestants are a type of medicine that can provide short-term relief for a blocked or stuffy nose (nasal congestion) … They work by reducing the swelling of the blood vessels in your nose, which helps to open the airways.","accessed":"2026-08-27"},{"id":"nhs_dec_kids","url":"https://www.nhs.uk/conditions/decongestants/","label":"NHS — Decongestants: babies and children","quote":"Decongestants should not be given to children under 6 years of age. Children aged 6 to 11 should take them for no longer than 5 days. Ask a pharmacist for advice about this.","accessed":"2026-08-27"},{"id":"nhs_dec_mix","url":"https://www.nhs.uk/conditions/decongestants/","label":"NHS — Decongestants: taking decongestants with other medicines","quote":"taking decongestants alongside some antidepressants can cause a dangerous rise in blood pressure. Do not use more than one medicine to treat a blocked nose at the same time. This includes using nasal sprays together or combining them with tablets","accessed":"2026-08-27"},{"id":"nhs_dec_preg","url":"https://www.nhs.uk/conditions/decongestants/","label":"NHS — Decongestants: pregnant and breastfeeding women","quote":"It's not clear whether it's safe to take any type of decongestant if you're pregnant, so you should only use them if told to by a healthcare professional.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}