{"ok":true,"entry":{"slug":"pearl-powder","kind":"supplement","name":"pearl powder","aliases":["zhen zhu fen","nacre powder"],"brands_sg":[],"class":"mineral/animal derivative","tags":["general"],"use_for":"traditional skin and beauty use · one small human rct","use_after":null,"use_duration":"the one rct ran 8 weeks of daily use","take_with":null,"pros":["one 8-week rct raised blood antioxidant capacity","long traditional use in tcm for skin and beauty"],"cons":["the rct had 20 people and measured blood markers","mostly calcium carbonate — hsa caps calcium at 1200 mg"],"dose_note":"the one human trial used 3 g a day (6 × 500 mg capsules) for 8 weeks","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["mollusc-derived — a shellfish allergy concern","calcium adds up — hsa caps supplement calcium at 1200 mg/day","not on hsa's prohibited/restricted lists — which are not exhaustive"],"clashes":[],"sources":[{"id":"chiu2018","url":"https://europepmc.org/article/PMC/PMC9332669","label":"Efficacy of protein rich pearl powder on antioxidant status in a randomized placebo-controlled trial (Chiu et al., J Food Drug Anal 2018)","quote":"20 healthy middle-aged subjects were recruited … who received 3 g of pearl powder/d (n = 10) and 3 g of placebo/d (n = 10) for 8 weeks … showed a substantial increase (p < 0.05) in total antioxidant capacity","accessed":"2026-08-27"},{"id":"loh2021","url":"https://europepmc.org/article/PMC/PMC8197316","label":"Pearl Powder — An Emerging Material for Biomedical Applications: A Review (Loh et al., Materials 2021)","quote":"Pearl powder is a well-known traditional Chinese medicine for a variety of indications from beauty care to healthcare … Calcium carbonate (CaCO3) and magnesium carbonate are the primary ingredients of mollusc shells","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5. … Table 5: Minerals Limits … Calcium 1200 mg","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}