{"ok":true,"entry":{"slug":"pantoprazole","kind":"medication","name":"pantoprazole","aliases":["Controloc","Pantotab"],"brands_sg":["Controloc","Pantotab","Peptazol","Pantin","Pantonex"],"class":"proton pump inhibitor","tags":["digestive"],"use_for":"prescribed for reflux, heartburn or stomach ulcers","use_after":"nhs: usually once a day, first thing in the morning","use_duration":null,"take_with":"water · healthhub: half to one hour before food","pros":["nhs: usually one tablet a day","nhs: no common side effects listed","healthhub: generally well-tolerated"],"cons":["nhs: uncommon headache, diarrhoea, nausea, constipation","healthhub: rare low magnesium; long use, low b12","nhs: not usually recommended in pregnancy"],"dose_note":"the us fda label for protonix gives 40 mg once daily for erosive oesophagitis and, for zollinger-ellison syndrome, '40 mg Twice daily … Doses up to 240 mg daily have been administered' — 240 mg a day is the highest number that label carries. nhs puts the usual range at 20 mg a day for heartburn and reflux up to 160 mg a day in zollinger-ellison syndrome. sg-registered tablets are 20 mg and 40 mg, and vials 40 mg. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["liver problems (nhs)","pregnant, trying to conceive or breastfeeding (nhs)","an endoscopy coming up — nhs: it may hide problems","low vitamin b12 levels (nhs)"],"clashes":[{"src":["nhs_panto_mix"],"note":"nhs lists medicines that help prevent blood clots among those to tell a doctor about","with":"warfarin and other clot-preventing medicines"},{"src":["nhs_panto_mix","hh_panto_interactions"],"note":"nhs and healthhub both list azole antifungals; stomach acid affects how they are absorbed","with":"itraconazole, posaconazole, voriconazole and other antifungals"},{"src":["nhs_panto_mix","hh_panto_interactions"],"note":"nhs and healthhub both list methotrexate as an interaction","with":"methotrexate"},{"src":["nhs_panto_mix","hh_panto_interactions"],"note":"nhs lists hiv medicines; healthhub names atazanavir and rilpivirine","with":"hiv medicines such as atazanavir and rilpivirine"},{"src":["nhs_panto_mix"],"note":"nhs lists the antibiotic rifampicin among medicines that may cause problems","with":"rifampicin"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered offline)","quote":"All 20 registered pantoprazole products carry Forensicclassification 'Prescription Only' — SIN08843P CONTROLOC TABLET 40 mg · SIN15863P PANTOTAB · SIN12452P PEPTAZOL 40 · SIN15041P PANTIN 40 · SIN14467P PANTONEX DR-40","accessed":"2026-08-27"},{"id":"nhs_panto_about","url":"https://www.nhs.uk/medicines/pantoprazole/","label":"NHS Medicines A-Z — Pantoprazole: about pantoprazole","quote":"Pantoprazole is a proton pump inhibitor (PPI) you can get on prescription or from a pharmacy. It's used for heartburn, acid reflux and stomach ulcers.","accessed":"2026-08-27"},{"id":"nhs_panto_dose","url":"https://www.nhs.uk/medicines/pantoprazole/how-and-when-to-take-pantoprazole/","label":"NHS Medicines A-Z — Pantoprazole: dosage and how to take it","quote":"The usual dose to treat: heartburn and acid reflux is 20mg a day … stomach ulcers is 40mg a day … Zollinger-Ellison syndrome is 80mg a day at first – this can increase to 160mg a day","accessed":"2026-08-27"},{"id":"nhs_panto_side","url":"https://www.nhs.uk/medicines/pantoprazole/side-effects-of-pantoprazole/","label":"NHS Medicines A-Z — Pantoprazole: side effects","quote":"There are no common side effects with this medicine. Uncommon side effects that happen in less than 1 in 100 people include headaches, diarrhoea, feeling or being sick, constipation, a dry mouth or feeling tired.","accessed":"2026-08-27"},{"id":"nhs_panto_who","url":"https://www.nhs.uk/medicines/pantoprazole/who-can-and-cannot-take-pantoprazole/","label":"NHS Medicines A-Z — Pantoprazole: who can and cannot take it","quote":"tell your doctor if you: have ever had an allergic reaction to pantoprazole … have liver problems … are pregnant, trying to get pregnant or breastfeeding … are due to have an endoscopy … have low levels of vitamin B12","accessed":"2026-08-27"},{"id":"nhs_panto_pregnancy","url":"https://www.nhs.uk/medicines/pantoprazole/pregnancy-breastfeeding-and-fertility-while-taking-pantoprazole/","label":"NHS Medicines A-Z — Pantoprazole: pregnancy, breastfeeding and fertility","quote":"Pantoprazole is not usually recommended because there is very little information about its use during pregnancy. Your doctor may recommend a similar medicine called omeprazole instead as there is more safety information available.","accessed":"2026-08-27"},{"id":"nhs_panto_mix","url":"https://www.nhs.uk/medicines/pantoprazole/taking-pantoprazole-with-other-medicines-and-herbal-supplements/","label":"NHS Medicines A-Z — Pantoprazole: taking it with other medicines and herbal supplements","quote":"antifungal medicines such as itraconazole, posaconazole or voriconazole; methotrexate … HIV medicines; rifampicin, an antibiotic; medicines that help to prevent blood clots, such as warfarin","accessed":"2026-08-27"},{"id":"hh_panto_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pantoprazole","label":"HealthHub (National Medication Information workgroup, SG) — Pantoprazole: what is this medication for","quote":"Pantoprazole is used to treat and prevent acid regurgitation … / gastroesophageal reflux disease or heartburn. It is also used to treat ulcers in the digestive tract or prevent ulcers caused by Non-Steroidal Anti-inflammatory (NSAID) drugs.","accessed":"2026-08-27"},{"id":"hh_panto_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pantoprazole","label":"HealthHub — Pantoprazole: how should I take or use this medication","quote":"Tablets should not be crushed or chewed and should be swallowed whole with water. Takes this medication half to one hour before food.","accessed":"2026-08-27"},{"id":"hh_panto_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pantoprazole","label":"HealthHub — Pantoprazole: common and rare side effects","quote":"Pantoprazole is generally well-tolerated … Rarely pantoprazole may cause low magnesium levels in the blood … Long term use of pantoprazole may lead to vitamin B12 deficiency which may result in fatigue and numbness.","accessed":"2026-08-27"},{"id":"hh_panto_interactions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/pantoprazole","label":"HealthHub — Pantoprazole: what food or medication should I avoid","quote":"Pantoprazole may interact with some medicines used to treat Human Immunodeficiency Virus (HIV) e.g. atazanavir and rilpivirine … methotrexate … itraconazole, ketoconazole, posaconazole (antifungal medication)","accessed":"2026-08-27"},{"id":"fda_protonix_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22PROTONIX%22&limit=1","label":"US FDA label for PROTONIX (pantoprazole sodium) delayed-release, section 2 Dosage and Administration, via openFDA drug/label.json (effective 2026-05-18)","quote":"Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome Adults 40 mg Twice daily … Doses up to 240 mg daily have been administered.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}