{"ok":true,"entry":{"slug":"panax-notoginseng","kind":"supplement","name":"panax notoginseng","aliases":["tienchi","san qi","Panax notoginseng","pseudoginseng"],"brands_sg":["California Gold Nutrition","Swanson Vitamins","NOW Foods","Imperial Elixir","Nutricost"],"class":"botanical","tags":["heart"],"use_for":"traditional use for bleeding, bruising and blood stasis","use_after":"trial schedule was twice daily","use_duration":"the trial ran 3 months, in patients","take_with":null,"pros":["a 2,966-patient trial tested oral saponins vs placebo","serious adverse events matched placebo in that trial","long recorded use for bleeding and swelling"],"cons":["that trial was in stroke patients, not healthy adults","with warfarin: raised inr and bruising reported","sg labels cannot claim stroke or clotting benefits"],"dose_note":"no rda, upper limit, fda daily value or hsa singapore daily limit exists for notoginseng; the largest human trial found (3,072 randomised across 67 chinese tertiary centres) gave xuesaitong soft capsules, 120 mg of panax notoginseng saponins orally twice daily for 3 months, to adults already diagnosed with ischaemic stroke and under hospital care — a medicine-style regimen in a patient group, not a general-adult supplement dose; the review of chinese medicine and warfarin describes notoginseng's recorded pharmacology as hemostasis, anti-thrombosis, vessel expansion and blood-pressure lowering, which is why the anticoagulant interaction matters more than any dose figure","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["on warfarin — inr rose and subcutaneous haemorrhage and ecchymosis were reported","on blood-pressure or heart medicines — vessel expansion and bp lowering are recorded effects","the trial evidence is in ischaemic-stroke patients under hospital care, not general adults","not listed in hsa's prohibited or restricted annexes — that is not a safety finding"],"clashes":[{"src":["noto_warfarin"],"note":"may raise inr, with subcutaneous haemorrhage and ecchymosis reported","with":"warfarin"}],"sources":[{"id":"noto_review","url":"https://europepmc.org/article/PMC/PMC11889391","label":"A narrative review of Panax notoginseng: Unique saponins and their pharmacological activities (Li, Shi & Wu, J Ginseng Res 2025)","quote":"Panax notoginseng (PN) is a precious traditional Chinese medicine (TCM) whose medicinal parts are roots and rhizomes for the treatment of haemorrhage, blood-stasis, swelling and pain.","accessed":"2026-08-27"},{"id":"noto_panda","url":"https://europepmc.org/article/PMC/PMC10282883","label":"Efficacy and Safety of Panax notoginseng Saponins in the Treatment of Adults With Ischemic Stroke in China: A Randomized Clinical Trial (JAMA Network Open 2023)","quote":"Eligible patients were randomly assigned … to receive either Xuesaitong soft capsules (120 mg orally twice daily) or placebo … for 3 months … serious adverse events occurred in 15 of 1488 patients (1.0%) … and 16 of 1482 (1.1%)","accessed":"2026-08-27"},{"id":"noto_warfarin","url":"https://europepmc.org/article/PMC/PMC8489681","label":"Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update (Front Pharmacol 2021) — notoginseng section","quote":"Therefore, Panax notoginseng combined with warfarin may cause increased INR and multiple subcutaneous hemorrhage and ecchymosis.","accessed":"2026-08-27"},{"id":"noto_warfarin_pharm","url":"https://europepmc.org/article/PMC/PMC8489681","label":"Front Pharmacol 2021 warfarin review — recorded pharmacology of Panax notoginseng (Sanqi)","quote":"has the effects of removing blood stasis, stopping bleeding, promoting blood circulation and relieving pain. Modern pharmacological effects include hemostasis (promoting blood clotting), anti-thrombosis, promoting hematopoiesis, inhibiting the heart, expanding blood vessels, and lowering blood pressure.","accessed":"2026-08-27"},{"id":"hsa_prohibited","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A (118 rows) and Annex B (4 rows) — panax notoginseng / tienchi / san qi / pseudoginseng NOT LISTED in either annex","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs_claims","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 6.6 and Table 6 (prohibited claims) — Blood and circulatory system row: Hypertension, stroke, cholesterol disorders, reduces cholesterol, regulates platelet aggregation, coagulation defects, arteriosclerosis","quote":"HS must not be labelled, advertised or promoted for any specific medicinal purpose, i.e. treatment or prevention, implied or otherwise, of any disease or disorder … Blood and circulatory system: Hypertension, stroke … regulates platelet aggregation, coagulation defects, arteriosclerosis","accessed":"2026-08-27"},{"id":"hsa_hs_limits","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4-5 (vitamins and minerals only — no botanical rows)","quote":"4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/ginseng","label":"iHerb Singapore — Ginseng category page, default listing order","quote":"1 - 48 of 101 results … California Gold Nutrition, Panax Ginseng Extract … Swanson Vitamins, Korean Red Ginseng … NOW Foods, Panax Ginseng … Imperial Elixir, Royal Jelly … Nutricost, Korean Red Ginseng … Imperial Elixir, Tienchi Ginseng","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}