{"ok":true,"entry":{"slug":"oxymetazoline","kind":"medication","name":"oxymetazoline","aliases":["Afrin","Iliadin"],"brands_sg":["Iliadin","Nazolin","Oxy-Nase","Clariclear"],"class":"topical nasal decongestant","tags":["cold-flu"],"use_for":"sg label: acute cold, sinusitis, syringitis, otitis media","use_after":"sg label: 1 puff each nostril 2–3 times daily, 5–7 days","use_duration":null,"take_with":"nhs: not alongside another blocked-nose medicine","pros":["hsa: general sale list — off the shelf in sg","us otc label: doses sit 10–12 hours apart","sg label: a 0.025% paediatric strength is registered"],"cons":["sg label: short courses of 5–7 days only","us otc label: no more than 3 days in a row","frequent use can make congestion recur or worsen"],"dose_note":"the singapore label maximum, from the moh national drug formulary page for ILIADIN SPRAY 0.05% [SIN02674P], reads \"Unless otherwise prescribed, spray 1 puff of Iliadin 0.05% Decongestant Nasal Spray into each nostril 2–3 times daily\", for \"adults and children of 6 years and older\", and \"should only be used for short periods of time (5 to 7 days). A treatment-free period of several days should precede any repeated use.\" the us otc drug facts label for Afrin Original Nasal (oxymetazoline hydrochloride 0.05%) is tighter: \"2 or 3 sprays in each nostril not more often than every 10 to 12 hours. Do not exceed 2 doses in any 24-hour period\" and \"do not use for more than 3 days\". the nhs puts the general limit for decongestant sprays and drops at \"more than 5 days at a time\". the pharmacist or doctor sets the dose.","dosage":null,"ul_status":null,"sg_class":"general-sale","cautions":["heart disease, high blood pressure, diabetes or thyroid disease (us otc label)","trouble urinating from an enlarged prostate (us otc label)","narrow-angle glaucoma, phaeochromocytoma or rhinitis sicca — sg label weighs the risk","pregnancy or breastfeeding — nhs: only if a healthcare professional says so"],"clashes":[{"src":["ndf_iliadin_maoi"],"note":"sg label: only after carefully weighing risk against benefit, along with other drugs that can raise blood pressure","with":"monoamine oxidase inhibitors (maois)"},{"src":["nhs_dec_mix"],"note":"nhs: taken with decongestants they can cause a dangerous rise in blood pressure","with":"some antidepressants"},{"src":["nhs_dec_mix"],"note":"nhs: sprays should not be combined with each other or with tablets and capsules for congestion","with":"any second blocked-nose medicine"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (never re-fetched), 10 oxymetazoline rows, 27 Aug 2026","quote":"ILIADIN SPRAY 0.05% (SIN02674P), ILIADIN SOLUTION 0.05%, 0.025% and 0.01%, NAZOLIN NASAL SPRAY 0.05%, OXY-NASE nasal spray and drops 0.05% and paediatric 0.025%, and CLARICLEAR NASAL SPRAY 0.05% all read \"General Sale List\", ATC R01AA05","accessed":"2026-08-27"},{"id":"ndf_iliadin_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02674p/","label":"MOH National Drug Formulary — ILIADIN SPRAY 0.05% [SIN02674P], Product information block","quote":"OXYMETAZOLINE HCL - 0.5 MG … Forensic Classification: GENERAL SALE LIST · Anatomical Therapeutic Chemical (ATC) code R01AA05 · Prescription-only Medicines with Exemptions for Supply without Prescription: NA","accessed":"2026-08-27"},{"id":"ndf_iliadin_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02674p/","label":"MOH National Drug Formulary — ILIADIN SPRAY 0.05% [SIN02674P], Indications","quote":"Acute cold, paranasal sinusitis, syringitis, otitis media.","accessed":"2026-08-27"},{"id":"ndf_iliadin_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02674p/","label":"MOH National Drug Formulary — ILIADIN SPRAY 0.05% [SIN02674P], Dosage, mode of administration and duration of treatment","quote":"spray 1 puff … into each nostril 2–3 times daily … may only be administered to adults and children of 6 years and older … should only be used for short periods of time (5 to 7 days)","accessed":"2026-08-27"},{"id":"ndf_iliadin_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02674p/","label":"MOH National Drug Formulary — ILIADIN SPRAY 0.05% [SIN02674P], Contraindications","quote":"Rhinitis sicca, hypersensitivity … children below six years of age. In the following cases this drug may only be used after carefully weighing the risk-to-benefit ratio: … Increased intraocular pressure, especially narrow-angle glaucoma; Severe cardiovascular diseases … Phaeochromocytoma","accessed":"2026-08-27"},{"id":"fda_afrin_purpose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1387514f-3c4b-46d0-873c-9eedf9721327","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Afrin Original Nasal, oxymetazoline hydrochloride 0.05%, Purpose and Uses","quote":"Oxymetazoline hydrochloride 0.05% Purpose Nasal decongestant … temporarily relieves nasal congestion due to: common cold; hay fever; upper respiratory allergies … shrinks swollen nasal membranes so you can breathe more freely","accessed":"2026-08-27"},{"id":"fda_afrin_dose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1387514f-3c4b-46d0-873c-9eedf9721327","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Afrin Original Nasal, Directions","quote":"2 or 3 sprays in each nostril not more often than every 10 to 12 hours. Do not exceed 2 doses in any 24-hour period. children under 6 years of age: ask a doctor.","accessed":"2026-08-27"},{"id":"fda_afrin_warn","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1387514f-3c4b-46d0-873c-9eedf9721327","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Afrin Original Nasal, Warnings","quote":"Ask a doctor before use if you have heart disease; high blood pressure; diabetes; thyroid disease; trouble urinating due to an enlarged prostate gland … do not use for more than 3 days","accessed":"2026-08-27"},{"id":"nhs_dec_about","url":"https://www.nhs.uk/conditions/decongestants/","label":"NHS — Decongestants (conditions A–Z), what they are","quote":"Decongestants are a type of medicine that can provide short-term relief for a blocked or stuffy nose (nasal congestion) … They work by reducing the swelling of the blood vessels in your nose, which helps to open the airways.","accessed":"2026-08-27"},{"id":"nhs_dec_how","url":"https://www.nhs.uk/conditions/decongestants/","label":"NHS — Decongestants: how to use decongestants","quote":"Most decongestants should only be used between 1 and 4 times a day … Decongestant nasal sprays and drops should not be used for more than 5 days at a time","accessed":"2026-08-27"},{"id":"nhs_dec_mix","url":"https://www.nhs.uk/conditions/decongestants/","label":"NHS — Decongestants: taking decongestants with other medicines","quote":"taking decongestants alongside some antidepressants can cause a dangerous rise in blood pressure. Do not use more than one medicine to treat a blocked nose at the same time. This includes using nasal sprays together or combining them with tablets","accessed":"2026-08-27"},{"id":"nhs_dec_preg","url":"https://www.nhs.uk/conditions/decongestants/","label":"NHS — Decongestants: pregnant and breastfeeding women","quote":"It's not clear whether it's safe to take any type of decongestant if you're pregnant, so you should only use them if told to by a healthcare professional.","accessed":"2026-08-27"},{"id":"fda_afrin_rebound","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1387514f-3c4b-46d0-873c-9eedf9721327","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Afrin Original Nasal, When using this product","quote":"do not use more than directed; do not use for more than 3 days. Use only as directed. Frequent or prolonged use may cause nasal congestion to recur or worsen.","accessed":"2026-08-27"},{"id":"ndf_iliadin_maoi","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02674p/","label":"MOH National Drug Formulary — ILIADIN SPRAY 0.05% [SIN02674P], Contraindications (risk-benefit list)","quote":"In the following cases this drug may only be used after carefully weighing the risk-to-benefit ratio: Patients treated with monamine oxidase inhibitors (MAO-inhibitors) and other drugs potentially increasing blood pressure","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}