{"ok":true,"entry":{"slug":"omeprazole","kind":"medication","name":"omeprazole","aliases":["Losec","Omez","Zimor"],"brands_sg":["Promesec","Zenpro","Losec MUPS","Zimor","Omicap"],"class":"proton-pump inhibitor","tags":["digestive"],"use_for":"heartburn, reflux (gord) and stomach ulcers per label","use_after":"once daily per label · 30–60 min before a meal (healthhub)","use_duration":null,"take_with":"water · capsules swallowed whole, not chewed or crushed","pros":["nhs: once or twice a day, with or without food","sg: 20 mg pharmacy-only packs exist (hsa register)","healthhub: relief often within days to weeks"],"cons":["otc label: not for immediate relief — 1 to 4 days","nhs: may mask symptoms of serious stomach conditions","long use: low magnesium, low b12, weaker bones"],"dose_note":"us otc drug facts (prilosec otc 20 mg, adults 18 and over): 'swallow 1 tablet with a glass of water before eating in the morning … do not take more than 1 tablet a day … do not use for more than 14 days unless directed by your doctor'; nhs: 'do not take omeprazole for longer than 2 weeks if you bought it without a prescription'; in singapore only two 20 mg products are pharmacy-only, the rest of the register is prescription only; as directed on the label or by your pharmacist or doctor","dosage":null,"ul_status":null,"sg_class":"pharmacy-only","cautions":["trouble swallowing, vomiting blood or black stools — otc label says do not use","heartburn over 3 months or unexplained weight loss — otc label says ask a doctor","kidney or liver condition, osteoporosis — nhs says it may not be suitable","pregnant or breastfeeding — healthhub and the otc label say tell a professional first"],"clashes":[{"src":["nhs_omep_int","healthhub_omep_int"],"note":"nhs and healthhub both list these as medicines that may not mix well with omeprazole","with":"warfarin, clopidogrel (blood thinners)"},{"src":["nhs_omep_int","healthhub_omep_int"],"note":"nhs lists these by name; healthhub lists hiv medicines as a group","with":"hiv medicines (nelfinavir, atazanavir)"},{"src":["nhs_omep_int","healthhub_omep_int"],"note":"nhs lists the anti-seizure medicine phenytoin, the heart medicine digoxin and the sedative diazepam","with":"phenytoin, digoxin, diazepam"},{"src":["nhs_omep_int"],"note":"nhs lists the herbal remedy for low mood among things that may not mix well","with":"st john's wort"},{"src":["healthhub_omep_int"],"note":"healthhub lists these under what to avoid; sg-facing list is wider than the nhs one","with":"ketoconazole, methotrexate, cyclosporin, iron salts"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (open dataset on data.gov.sg, resource d_767279312753558cbf19d48344577084, pulled via datastore_search API; 38 omeprazole/esomeprazole rows read)","quote":"PROMESEC GASTRO-RESISTANT CAPSULES 20 MG (PHARMACY ONLY) · Pharmacy Only — ZENPRO CAPSULE 20MG (PHARMACY ONLY) · Pharmacy Only — LOSEC MUPS TABLET 20 mg · Prescription Only — ZIMOR 20 CAPSULE 20 mg · Prescription Only","accessed":"2026-08-27"},{"id":"hsa_reclass","url":"https://www.hsa.gov.sg/therapeutic-products/registration-of-therapeutic-products/variation-application/reclassification/list-of-reclassified-medicines/","label":"HSA — List of reclassified medicines (forensic classification definitions: POM / P / GSL)","quote":"Pharmacy-Only Medicine (P): A therapeutic product that can be obtained from a pharmacist at a retail pharmacy without a prescription … Prescription-Only Medicine (POM): … can only be obtained from a doctor or from a pharmacist with a valid prescription","accessed":"2026-08-27"},{"id":"healthhub_omep","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/omeprazole","label":"HealthHub (MOH Singapore) — Omeprazole medication information leaflet (article last reviewed 12 June 2026)","quote":"Omeprazole is used to treat various conditions of the gastrointestinal … tract including: Gastro-oesophageal reflux disease … Ulcers of the gastrointestinal tract … Take this medication 30 to 60 minutes before a meal. Capsules should be swallowed whole with water","accessed":"2026-08-27"},{"id":"healthhub_omep_safe","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/omeprazole","label":"HealthHub (MOH Singapore) — Omeprazole leaflet, precautions and side-effects sections (same page)","quote":"Inform your healthcare professional if: … You are pregnant, planning to become pregnant, or breastfeeding … may cause the level of magnesium in your body to decrease if you use it for long duration","accessed":"2026-08-27"},{"id":"healthhub_omep_course","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/omeprazole","label":"HealthHub (MOH Singapore) — Omeprazole leaflet, length-of-treatment section (same page)","quote":"The length of treatment with omeprazole depends on your condition and how well you respond to the medication … Most people experience relief within the first few days to weeks of starting omeprazole","accessed":"2026-08-27"},{"id":"healthhub_omep_int","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/omeprazole","label":"HealthHub (MOH Singapore) — Omeprazole leaflet, food and medication interactions section (same page)","quote":"Certain blood thinners (e.g. warfarin, clopidogrel) … Certain anti-fungal medicines (e.g. ketoconazole) … Certain drugs to treat seizures (e.g. phenytoin) … Other medicines such as digoxin, cyclosporin, methotrexate and iron salts","accessed":"2026-08-27"},{"id":"nhs_omep","url":"https://www.nhs.uk/medicines/omeprazole/","label":"NHS — Omeprazole: a medicine to treat heartburn and indigestion (page last reviewed 17 September 2025)","quote":"Omeprazole is a medicine called a proton pump inhibitor (PPI). It reduces the amount of acid in your stomach … It's usually taken once or twice a day … you can take it with or without food","accessed":"2026-08-27"},{"id":"nhs_omep_limit","url":"https://www.nhs.uk/medicines/omeprazole/","label":"NHS — Omeprazole, 'How to take omeprazole' important box (same page)","quote":"Do not take omeprazole for longer than 2 weeks if you bought it without a prescription … Taking omeprazole can make it harder to notice symptoms of some serious conditions","accessed":"2026-08-27"},{"id":"nhs_omep_safe","url":"https://www.nhs.uk/medicines/omeprazole/","label":"NHS — Omeprazole, 'Who can and cannot take omeprazole' and 'Serious side effects' (same page)","quote":"it may not be suitable if … you have a kidney or liver condition … you have osteoporosis (weakened bones) … having a very low level of vitamin B12 … weakened bones, which can break more easily","accessed":"2026-08-27"},{"id":"nhs_omep_int","url":"https://www.nhs.uk/medicines/omeprazole/","label":"NHS — Omeprazole, 'Taking omeprazole with other medicines, food and drink' (same page)","quote":"some medicines to prevent blood clots, such as warfarin and clopidogrel … the sedative diazepam … the anti-seizure medicine phenytoin … the herbal remedy for low mood, St John's Wort … HIV medicines called nelfinavir and atazanavir","accessed":"2026-08-27"},{"id":"fda_prilosec_use","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=37291cab-e350-d8e3-e063-6294a90a9cb1","label":"DailyMed / FDA — PRILOSEC OTC (omeprazole magnesium 20 mg) delayed-release tablet, OTC Drug Facts 'Uses' (label updated 29 July 2026)","quote":"treats frequent heartburn (occurs 2 or more days a week) … not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect","accessed":"2026-08-27"},{"id":"fda_prilosec_dose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=37291cab-e350-d8e3-e063-6294a90a9cb1","label":"DailyMed / FDA — PRILOSEC OTC, OTC Drug Facts 'Directions' (same label)","quote":"swallow 1 tablet with a glass of water before eating in the morning … do not take more than 1 tablet a day … do not use for more than 14 days unless directed by your doctor","accessed":"2026-08-27"},{"id":"fda_prilosec_warn","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=37291cab-e350-d8e3-e063-6294a90a9cb1","label":"DailyMed / FDA — PRILOSEC OTC, OTC Drug Facts 'Warnings' (same label)","quote":"Do not use if you have: trouble or pain swallowing food, vomiting with blood, or bloody or black stools … Ask a doctor before use if you have: had heartburn over 3 months … unexplained weight loss","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:27.496708+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}