{"ok":true,"entry":{"slug":"olanzapine","kind":"medication","name":"olanzapine","aliases":["Zyprexa"],"brands_sg":["Zyprexa","Zyprexa Zydis","Onzapin","Olankline","Olanzapine STADA"],"class":"atypical antipsychotic","tags":["mental-health"],"use_for":"healthhub: schizophrenia and bipolar mood symptoms","use_after":"healthhub: once daily, with or without food","use_duration":null,"take_with":"water · nhs: alcohol can make you sleepy or unsteady","pros":["sg label: acute and maintenance use in schizophrenia","healthhub: may be taken with or without food","sg label: plain and orodispersible tablets in sg"],"cons":["nhs: sleepiness, weight gain, dizziness, constipation","healthhub: can worsen blood sugar control in diabetes","nhs: it may take days or weeks before symptoms improve"],"dose_note":"the singapore zyprexa label sets a range rather than one ceiling: the starting dose is '10 mg/day' in schizophrenia and '15mg as a single daily dose in monotherapy' for a manic episode, and 'daily dosage may subsequently be adjusted on the basis of individual clinical status within the range 5–20 mg/day'. the us zyprexa label says it outright: 'olanzapine is not indicated for use in doses above 20 mg/day'. nhs adds that 'most people feel better with daily doses of 5mg to 20mg'. sg-registered strengths are 5 mg and 10 mg only, so 20 mg is reached by combining tablets.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["diabetes — healthhub: it may worsen blood sugar control","heart rhythm problems, stroke or past blood clots (nhs)","parkinson's, dementia, seizures or glaucoma (healthhub)","a change in smoking — healthhub: smoking lowers the drug level"],"clashes":[{"src":["nhs_ola_about"],"food":true,"note":"nhs: can make you sleepy or unsteady and worsen symptoms","with":"alcohol"},{"src":["nhs_ola_int"],"note":"nhs: listed as medicines that may affect how olanzapine works","with":"fluvoxamine, ciprofloxacin or carbamazepine"},{"src":["nhs_ola_int"],"note":"nhs: olanzapine can increase their sleepiness","with":"sedating medicines (benzodiazepines, morphine, antihistamines)"},{"src":["nhs_ola_int"],"note":"nhs: might affect how olanzapine works","with":"cannabidiol (cbd)"},{"src":["hh_ola_precautions"],"note":"healthhub: smoking may lower how much stays in the body","with":"smoking"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 21 registered olanzapine products read 'Prescription Only' and every one is a 5 mg or 10 mg oral tablet — ZYPREXA · ZYPREXA ZYDIS · Onzapin · OLANKLINE · Olanzapine STADA · OLANCOR · TOLANZ ODT · JUBREXA","accessed":"2026-08-27"},{"id":"ndf_zyprexa","url":"https://www.ndf.gov.sg/about-drugs/product-information/SIN09410P","label":"National Drug Formulary (SG, MOH) — ZYPREXA TABLET 10 MG [SIN09410P], approved indications and posology","quote":"indicated for the acute and maintenance treatment of schizophrenia … daily dosage may subsequently be adjusted on the basis of individual clinical status within the range 5–20 mg/day … The recommended starting dose for olanzapine is 10 mg/day","accessed":"2026-08-27"},{"id":"hh_ola_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/olanzapine","label":"HealthHub (National Medication Information workgroup, SG) — Olanzapine: what is this medication for","quote":"Olanzapine belongs to a class of medications known as atypical (second-generation) antipsychotics. It is used to treat and prevent return of symptoms in Schizophrenia … It can be used to treat symptoms in bipolar disorder","accessed":"2026-08-27"},{"id":"hh_ola_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/olanzapine","label":"HealthHub — Olanzapine: how should I take or use this medication","quote":"Olanzapine should be taken with or without food. Olanzapine is available as orodispersible tablets … Olanzapine needs to be taken regularly for a few weeks before you can feel its full benefits.","accessed":"2026-08-27"},{"id":"hh_ola_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/olanzapine","label":"HealthHub — Olanzapine: what precautions should I take","quote":"You have diabetes. Olanzapine may sometimes worsen blood sugar control in diabetes … You are smoking or have any changes to your smoking habits. Smoking may decrease the amount of Olanzapine that stays in your body.","accessed":"2026-08-27"},{"id":"nhs_ola_about","url":"https://www.nhs.uk/medicines/olanzapine/about-olanzapine/","label":"NHS — About olanzapine (brand name: Zyprexa), Key facts","quote":"Olanzapine does not work straight away. It may take several days, or even weeks, for some of your symptoms to start improving … Drinking alcohol with olanzapine can make you feel sleepy or unsteady","accessed":"2026-08-27"},{"id":"nhs_ola_side","url":"https://www.nhs.uk/medicines/olanzapine/side-effects-of-olanzapine/","label":"NHS — Side effects of olanzapine","quote":"These common side effects of olanzapine may affect up to 1 in 10 people … Feeling sleepy in the day … Putting on weight or an increase in your appetite … Feeling dizzy … Rash … Constipation","accessed":"2026-08-27"},{"id":"nhs_ola_who","url":"https://www.nhs.uk/medicines/olanzapine/who-can-and-cannot-take-olanzapine/","label":"NHS — Who can and cannot take olanzapine","quote":"tell your doctor before starting to take it if you have: … a heart problem, including an irregular heartbeat … had a stroke … had a blood clot … Parkinson's disease dementia … diabetes epilepsy … glaucoma","accessed":"2026-08-27"},{"id":"nhs_ola_int","url":"https://www.nhs.uk/medicines/olanzapine/taking-olanzapine-with-other-medicines-and-herbal-supplements/","label":"NHS — Taking olanzapine with other medicines and herbal supplements","quote":"carbamazepine, a medicine for epilepsy fluvoxamine, used to treat depression ciprofloxacin, an antibiotic medicines that make you feel calm or sleepy … Cannabidiol (also known as CBD) might affect how olanzapine works","accessed":"2026-08-27"},{"id":"nhs_ola_dose","url":"https://www.nhs.uk/medicines/olanzapine/how-and-when-to-take-olanzapine/","label":"NHS — Dosage and how to take olanzapine","quote":"Most people feel better with daily doses of 5mg to 20mg … Take olanzapine once a day, at the same time each day. You can take it with or without food.","accessed":"2026-08-27"},{"id":"fda_zyprexa_max","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ZYPREXA%22+AND+openfda.route:%22ORAL%22&limit=3","label":"US FDA label — ZYPREXA (olanzapine) oral, section 2.1 Schizophrenia, via openFDA","quote":"Olanzapine is not indicated for use in doses above 20 mg/day.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}