{"ok":true,"entry":{"slug":"ofloxacin","kind":"medication","name":"ofloxacin","aliases":["Tarivid","levofloxacin precursor"],"brands_sg":["Fugacin","Ofcin","Akilen","Oflox","Flovid"],"class":"fluoroquinolone antibiotic","tags":["antibiotic"],"use_for":"sg label: urinary, chest, skin and genital tract infections","use_after":"medlineplus: once or twice a day, doses about 12 hours apart","use_duration":null,"take_with":"water · medlineplus: 2 hours apart from antacids and iron","pros":["medlineplus: kills the bacteria that cause infections","sg label: gonorrhoea treated as a single 400 mg dose","sg label: oral tablets, no drip needed"],"cons":["us boxed warning: tendinitis and tendon rupture risk","us boxed warning: nerve damage and cns effects","medlineplus: skin can turn sensitive to sunlight"],"dose_note":"the singapore ofcin (ofloxacin) label's ceiling is '400mg twice daily' — reached only if needed in upper urinary tract and lower respiratory tract infections — with 'uncomplicated gonorrhoea: 400mg as a single dose'. the us ofloxacin tablet label's dosing chart tops out at the same 800 mg daily dose, and for liver disease states 'a maximum dose of 400 mg of ofloxacin per day should therefore not be exceeded'. both labels halve the dose when creatinine clearance is 20–50 ml/min. sg-registered strengths are 200 mg and 400 mg tablets only.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["epilepsy or a lowered seizure threshold — sg label: contraindicated","pregnancy, breastfeeding or growing adolescents — sg label: contraindicated","myasthenia gravis — us boxed warning: muscle weakness can worsen","over 60, on steroids, or a transplant — medlineplus: tendon risk is highest"],"clashes":[{"src":["fda_oflox_dose","mlp_ofloxacin"],"note":"us label: not within two hours before or after a dose","with":"antacids, iron, zinc, sucralfate, didanosine"},{"src":["mlp_ofloxacin"],"note":"medlineplus: raises the tendinitis and tendon-rupture risk","with":"oral or injected steroids"},{"src":["mlp_ofloxacin"],"note":"medlineplus: listed as products that may interact","with":"nsaids such as ibuprofen or naproxen, and cimetidine"},{"src":["mlp_ofloxacin"],"note":"medlineplus: skin may become sensitive, reddened or blistered","with":"sunlight and uv lamps"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 6 rows whose active ingredient is exactly 'OFLOXACIN' read 'Prescription Only' — FUGACIN TABLET 200 mg · OFCIN 200 mg and 400 mg · AKILEN TABLET 200 mg · OFLOX TABLET 200 mg · FLOVID 200 (all ATC J01MA01)","accessed":"2026-08-27"},{"id":"ndf_ofcin","url":"https://www.ndf.gov.sg/about-drugs/product-information/SIN10118P","label":"National Drug Formulary (SG, MOH) — OFCIN FILM COATED TABLET 400 MG [SIN10118P], approved indication and dosing","quote":"Urinary tract infections: 200 to 400mg daily … increased if necessary in upper urinary tract infections to 400mg twice daily … Uncomplicated gonorrhoea: 400mg as a single dose … contraindicated in patients with a history of epilepsy","accessed":"2026-08-27"},{"id":"mlp_ofloxacin","url":"https://medlineplus.gov/druginfo/meds/a691005.html","label":"MedlinePlus (NIH/AHFS) — Ofloxacin, including the IMPORTANT WARNING section","quote":"Ofloxacin increases the risk of tendinitis … or tendon rupture … the risk is highest in people over 60 years of age … take them 2 hours before or 2 hours after ofloxacin","accessed":"2026-08-27"},{"id":"fda_oflox_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22OFLOXACIN%22+AND+openfda.route:%22ORAL%22&limit=3","label":"US FDA label — ofloxacin tablets USP, DOSAGE AND ADMINISTRATION, via openFDA","quote":"The usual dose of ofloxacin tablets is 200 mg to 400 mg orally every 12 h … A maximum dose of 400 mg of ofloxacin per day should therefore not be exceeded [cirrhosis]","accessed":"2026-08-27"},{"id":"fda_oflox_boxed","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22OFLOXACIN%22+AND+openfda.route:%22ORAL%22&limit=3","label":"US FDA label — ofloxacin tablets USP, boxed warning, via openFDA","quote":"Fluoroquinolones, including ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions … Tendinitis and tendon rupture Peripheral neuropathy Central nervous system effects … may exacerbate muscle weakness in … myasthenia gravis","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}