{"ok":true,"entry":{"slug":"nortriptyline","kind":"medication","name":"nortriptyline","aliases":["Pamelor"],"brands_sg":["Apo-Nortriptyline"],"class":"tricyclic antidepressant","tags":["mental-health"],"use_for":"healthhub: symptoms of depression such as low mood","use_after":"healthhub: with or without food","use_duration":null,"take_with":"water · hh: alcohol can worsen low mood and add sleepiness","pros":["hh: a tricyclic for depression symptoms","hh: may be taken with or without food","hsa: 10 mg and 25 mg capsules registered in sg"],"cons":["hh: dry mouth, constipation, drowsiness, weight gain","hh: skin gets more sensitive to sunlight","hh: stopping suddenly brings dizziness, nausea"],"dose_note":"the us pamelor label's dosage section gives a usual adult dose of '25 mg three or four times daily' and states 'doses above 150 mg/day are not recommended'. above 100 mg daily the same label asks for plasma nortriptyline 'maintained in the optimum range of 50 to 150 ng/mL'. for elderly and adolescent patients it gives '30 to 50 mg/day, in divided doses', and it says 'pamelor is not recommended for children'. singapore registers 10 mg and 25 mg capsules only, and the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["heart, kidney or liver disease — healthhub","glaucoma, enlarged prostate or difficulty passing urine (hh)","bipolar disorder, mania, seizures, thyroid or diabetes (hh)","under 25 — healthhub warns of new self-harm thoughts early on"],"clashes":[{"src":["hh_nor_avoid"],"food":true,"note":"healthhub: it can worsen depression symptoms and cause excessive sleepiness","with":"alcohol"},{"src":["hh_nor_precautions"],"note":"healthhub lists this among what the prescriber must be told","with":"any other mood medicine taken in the past 2 weeks"},{"src":["fda_pamelor_maoi"],"note":"us label: at least 14 days should elapse in either direction","with":"maois (psychiatric)"},{"src":["fda_pamelor_maoi"],"note":"us label: increased risk of serotonin syndrome","with":"linezolid or intravenous methylene blue"},{"src":["hh_nor_precautions"],"note":"healthhub: some may affect how it works or cause serious drug interactions","with":"st john's wort, other medicines and herbal remedies"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"Both registered nortriptyline products read 'Prescription Only' — SIN09253P APO-NORTRIPTYLINE CAPSULE 25 mg and SIN09255P APO-NORTRIPTYLINE CAPSULE 10 mg, active ingredient NORTRIPTYLINE HCl, ATC N06AA10.","accessed":"2026-08-27"},{"id":"hh_nor_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nortriptyline","label":"HealthHub (National Medication Information workgroup, SG) — Nortriptyline: what is this medication for","quote":"Nortriptyline belongs to a class of medications known as Tricyclic antidepressants (TCA). It is used to treat symptoms of depression such as: Feeling sad, Loss of interest in usual activities, Feeling hopeless or worthless","accessed":"2026-08-27"},{"id":"hh_nor_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nortriptyline","label":"HealthHub — Nortriptyline: how should I take this medication","quote":"Nortriptyline may be taken with or without food … You may experience unpleasant effects such as dizziness, headache, difficulty sleeping, irritability, and nausea if you suddenly stop taking the medication on your own.","accessed":"2026-08-27"},{"id":"hh_nor_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nortriptyline","label":"HealthHub — Nortriptyline: what precautions should I take","quote":"Heart, kidney or liver disease … difficulty in urination, enlarged prostate gland, overactive thyroid gland … seizures (fits), Parkinson's disease, or increased eye pressure (glaucoma) or diabetes … bipolar disorder … Your skin may become more sensitive to sunlight","accessed":"2026-08-27"},{"id":"hh_nor_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nortriptyline","label":"HealthHub — Nortriptyline: common side effects","quote":"Nausea, vomiting or loss of appetite … Drowsiness or feeling tired … Dry mouth … Constipation … Diarrhoea … Dizziness … Mild nervousness … Weight gain … decreased sexual drive or ability","accessed":"2026-08-27"},{"id":"hh_nor_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nortriptyline","label":"HealthHub — Nortriptyline: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking Nortriptyline as it can worsen the symptoms of your depression and cause excessive sleepiness.","accessed":"2026-08-27"},{"id":"hh_nor_young","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/nortriptyline","label":"HealthHub — Nortriptyline: important warning for people under 25","quote":"The following changes have been observed in some patients particularly below the age of 25 years … New or worsening thoughts of harming yourself or ending your life; Worsening agitation, restlessness, violent behaviour","accessed":"2026-08-27"},{"id":"fda_pamelor_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22PAMELOR%22&limit=1","label":"US FDA label for PAMELOR (nortriptyline hydrochloride), DOSAGE AND ADMINISTRATION, via openFDA (SpecGx LLC, effective 2024-12-04)","quote":"Usual Adult Dose – 25 mg three or four times daily … When doses above 100 mg daily are administered, plasma levels … Doses above 150 mg/day are not recommended.","accessed":"2026-08-27"},{"id":"fda_pamelor_maoi","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22PAMELOR%22&limit=1","label":"US FDA label for PAMELOR, MAOI switching and linezolid / methylene blue, via openFDA","quote":"At least 14 days should elapse between discontinuation of an MAOI … and initiation of therapy with Pamelor … Do not start Pamelor in a patient … treated with linezolid or intravenous methylene blue … risk of serotonin syndrome.","accessed":"2026-08-27"},{"id":"fda_pamelor_special","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22PAMELOR%22&limit=1","label":"US FDA label for PAMELOR, dosage in children, adolescents and elderly patients, via openFDA","quote":"Pamelor is not recommended for children … Elderly and Adolescent Patients – 30 to 50 mg/day, in divided doses, or the total daily dosage may be given once a day.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}