{"ok":true,"entry":{"slug":"nifedipine","kind":"medication","name":"nifedipine","aliases":["Adalat"],"brands_sg":["Adalat LA","Nifelat","Depin-E Retard","Calcigard Retard","Nifecard XL"],"class":"calcium channel blocker","tags":["heart-bp"],"use_for":"nhs: high blood pressure, angina and raynaud's","use_after":"nhs: 1 to 3 times a day, depending on the form","use_duration":null,"take_with":"water · nhs: with or without food, but no grapefruit","pros":["nhs: usually 1 to 3 times a day, form-dependent","nhs: also prescribed for raynaud's, not just bp/angina","nhs: usually fine with or without food"],"cons":["nhs: headaches, flushing and swollen ankles are common","nhs: grapefruit raises the chance of side effects","nhs: may not suit heart failure or unstable angina"],"dose_note":"no singapore package insert was read, and the two us extended-release nifedipine labels read do not agree on the ceiling. one states \"It is recommended that nifedipine extended-release tablet be administered orally once daily on an empty stomach … The usual maintenance dose is 30 mg to 60 mg once daily. Titration to doses above 90 mg daily is not recommended\". the other states \"Therapy for either hypertension or angina should be initiated with 30 or 60 mg once daily … Titration to doses above 120 mg are not recommended\". the sg register carries 5, 10, 20, 30 and 60 mg single-ingredient strengths, including adalat la 30. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["low blood pressure — nhs: it may lower blood pressure further","heart failure, unstable angina, or angina that is getting worse (nhs)","diabetes, or a severe liver or kidney condition (nhs)","pregnant or breastfeeding — nhs: usually possible, a doctor decides"],"clashes":[{"src":["nhs_nife_food"],"food":true,"note":"nhs: it can increase the chance of side effects","with":"grapefruit and grapefruit juice"},{"src":["nhs_nife_mix"],"note":"nhs lists these among medicines that may not mix well","with":"other blood pressure medicines"},{"src":["nhs_nife_mix"],"note":"nhs lists these among medicines that may not mix well","with":"cimetidine and other stomach ulcer medicines"},{"src":["nhs_nife_mix"],"note":"nhs lists heart medicines among those that may not mix well","with":"digoxin and beta blockers"},{"src":["nhs_nife_mix"],"note":"nhs lists epilepsy medicines, some antibiotics and antifungals","with":"carbamazepine, some antibiotics and antifungals"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), nifedipine rows, 27 Aug 2026","quote":"ADALAT LA 30 SIN07710P · NIFELAT SIN07228P · DEPIN-E RETARD SIN11117P · CALCIGARD RETARD SIN12483P · NIFECARD XL SIN11720P — ATC C08CA05, strengths 5/10/20/30/60 mg; all 11 nifedipine rows read Forensicclassification \"Prescription Only\"","accessed":"2026-08-27"},{"id":"nhs_nife_about","url":"https://www.nhs.uk/medicines/nifedipine/","label":"NHS medicines A–Z — Nifedipine: what nifedipine is for (reviewed 20 May 2026)","quote":"Nifedipine is a medicine that treats high blood pressure, angina and a condition called Raynaud's, which affects blood flow. It's only available with a prescription.","accessed":"2026-08-27"},{"id":"nhs_nife_howto","url":"https://www.nhs.uk/medicines/nifedipine/","label":"NHS medicines A–Z — Nifedipine: how to take nifedipine","quote":"Nifedipine usually comes as capsules or tablets that you swallow. You'll usually need to take it 1 to 3 times a day, depending on the type of capsule or tablet you have. You can take nifedipine with our without food.","accessed":"2026-08-27"},{"id":"nhs_nife_side","url":"https://www.nhs.uk/medicines/nifedipine/","label":"NHS medicines A–Z — Nifedipine: side effects","quote":"Common side effects of nifedipine include: headaches; flushing …; generally feeling unwell; finding it difficult to poo (constipation); swollen ankles (oedema)","accessed":"2026-08-27"},{"id":"nhs_nife_who","url":"https://www.nhs.uk/medicines/nifedipine/","label":"NHS medicines A–Z — Nifedipine: who can and cannot take nifedipine","quote":"nifedipine may not be suitable if you have: … low blood pressure …; a heart condition, such as heart failure; unstable angina … or angina that is getting worse; diabetes; a severe liver or kidney condition","accessed":"2026-08-27"},{"id":"nhs_nife_preg","url":"https://www.nhs.uk/medicines/nifedipine/","label":"NHS medicines A–Z — Nifedipine: pregnancy and breastfeeding","quote":"You can usually take nifedipine if you're breastfeeding … You can usually take nifedipine if you're pregnant.","accessed":"2026-08-27"},{"id":"nhs_nife_mix","url":"https://www.nhs.uk/medicines/nifedipine/","label":"NHS medicines A–Z — Nifedipine: taking nifedipine with other medicines","quote":"other blood pressure medicines; some antibiotics; stomach ulcer medicines, such as cimetidine; medicines for heart conditions, such as digoxin or beta blockers; epilepsy medicines such as carbamazepine; medicines to treat fungal infections","accessed":"2026-08-27"},{"id":"nhs_nife_food","url":"https://www.nhs.uk/medicines/nifedipine/","label":"NHS medicines A–Z — Nifedipine: food, drink and alcohol","quote":"Do not eat grapefruit or drink grapefruit juice while taking nifedipine because it can increase the chance of side effects.","accessed":"2026-08-27"},{"id":"fda_nife_er90","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22nifedipine%22&limit=5","label":"US label for nifedipine extended-release tablets (Bryant Ranch Prepack, effective 2026-03-19) via openFDA drug/label.json, Dosage and Administration","quote":"It is recommended that nifedipine extended-release tablet be administered orally once daily on an empty stomach … The usual maintenance dose is 30 mg to 60 mg once daily. Titration to doses above 90 mg daily is not recommended.","accessed":"2026-08-27"},{"id":"fda_nife_er120","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22nifedipine%22&limit=5","label":"US label for nifedipine extended-release tablets (Chartwell RX, effective 2025-12-17) via openFDA drug/label.json, Dosage and Administration","quote":"Therapy for either hypertension or angina should be initiated with 30 or 60 mg once daily … Titration to doses above 120 mg are not recommended.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}