{"ok":true,"entry":{"slug":"nicotine","kind":"medication","name":"nicotine","aliases":["Nicorette","NRT patch","nicotine gum","Nicotinell"],"brands_sg":["Nicorette","Nicotinell","Skiip"],"class":"nicotine replacement therapy","tags":["other"],"use_for":"withdrawal symptoms and cravings when stopping smoking","use_after":"patch on waking, off at bedtime · gum when a craving comes","use_duration":null,"take_with":"advice and support — the sg label says they improve success","pros":["cochrane 2018: rr 1.55 for quitting vs control","cochrane judged the evidence high quality","pharmacy only in sg — no prescription needed"],"cons":["pharmacy only — not on the open shelf in sg","sg label: patch off at night, sleep can be disturbed","sg label: regular use past 12 months not advised"],"dose_note":"the singapore nicorette icy mint gum 2 mg label [SIN14326P] reads 'do not exceed the following quantity in any 24-hour period: 2mg: 30 gums / 4mg: 24 gums' and 'most people use between 8 to 12 gums per day'; the nicorette invisi transdermal patch 25 mg/16 hours label [SIN14296P] reads 'use one new patch per day' and 'do not use more than one patch at a time' — 30 × 2 mg gums (or 24 × 4 mg gums) in 24 hours, or one patch a day, is the largest amount those labels state. used together, the gum label caps the 2 mg gum at 12 a day alongside a patch and says the patch 'should NOT be used with Nicorette Icy Mint Gum 4mg'; both labels add that 'regular use beyond 12 months is generally not recommended'; as directed on the label or by your pharmacist or doctor","dosage":null,"ul_status":null,"sg_class":"pharmacy-only","cautions":["an allergy to nicotine or any ingredient — both sg labels say not to use it","red, cut or irritated skin — the sg patch label says not to place a patch there","symptoms of nicotine excess — the sg gum label says dosing is stopped temporarily","pregnancy, heart conditions and age limits are named by NEITHER sg ndf page — untested here, not shown safe"],"clashes":[{"src":["ndf_nicorette_gum","ndf_nicorette_patch"],"note":"both sg labels state the patch should NOT be used with the 4 mg gum; with a patch the 2 mg gum is capped at 12 a day","with":"nicorette invisi patch plus the 4 mg icy mint gum"},{"src":["ndf_nicorette_gum","ndf_nicorette_patch"],"note":"the sg labels say smokers should stop smoking completely during the course of treatment","with":"continued smoking"},{"src":["ndf_nicorette_gum","ndf_nicorette_patch"],"note":"neither ndf page publishes an interaction section — untested, not shown safe","with":"nothing else documented on the sg registrations"}],"sources":[{"id":"ndf_nicorette_gum","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14326p/","label":"MOH National Drug Formulary — NICORETTE ICY MINT MEDICATED CHEWING GUM 2MG [SIN14326P], indication and dosing (page last updated 28 Jul 2026)","quote":"used to relieve withdrawal symptoms and reduce the cravings for nicotine that you get when you try to stop smoking. Advice and support normally improve the success rate … Do not exceed the following quantity in any 24-hour period: 2mg: 30 gums 4mg: 24 gums … Regular use beyond 12 months is generally not recommended","accessed":"2026-08-27"},{"id":"ndf_nicorette_patch","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14296p/","label":"MOH National Drug Formulary — NICORETTE INVISI TRANSDERMAL PATCH 25MG/16 HOURS [SIN14296P], dosing and 'things you must not do'","quote":"Use one new patch per day. Apply when you wake up … and remove 16 hours later … Do not use more than one patch at a time … The patch should not be kept on at night while sleeping as it may cause nicotine-induced sleep disturbance … Avoid placing the patch onto any area of skin that is red, cut or irritated","accessed":"2026-08-27"},{"id":"ndf_nicorette_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin14326p/","label":"MOH National Drug Formulary — NICORETTE ICY MINT MEDICATED CHEWING GUM 2MG [SIN14326P], product information fields","quote":"Active Ingredient and Strength NICOTINE RESINATE 10 MG EQUIV NICOTINE - 2 MG … Forensic Classification PHARMACY ONLY MEDICINES … Anatomical Therapeutic Chemical (ATC) code N07BA01","accessed":"2026-08-27"},{"id":"hsa_register_nic","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA register of therapeutic products (data.gov.sg d_767279312753558cbf19d48344577084) — 18 nicotine rows, filtered locally from the cached copy on 27 Aug 26","quote":"Nicorette Icy Mint Medicated Chewing Gum 2mg … Pharmacy Only … Nicorette Invisi Transdermal Patch 10mg/15mg/25mg/16 hours … Pharmacy Only … NICORETTE QUICKMIST MOUTHSPRAY 1MG/SPRAY … NICOTINELL TTS 10/20/30 … NICOTINELL MINT LOZENGE 1 mg … SKIIP NICOTINE MINI LOZENGE 2 MG … N07BA01","accessed":"2026-08-27"},{"id":"cochrane_nrt2018","url":"https://europepmc.org/article/PMC/PMC6353172","label":"Cochrane Database of Systematic Reviews — Nicotine replacement therapy versus control for smoking cessation (Hartmann-Boyce, Chepkin, Ye, Bullen, Lancaster 2018; PMC6353172)","quote":"We identified 136 studies; 133 with 64,640 participants … We judged the evidence to be of high quality … The RR of abstinence for any form of NRT relative to control was 1.55 (95% confidence interval (CI) 1.49 to 1.61) … 1.49 … for nicotine gum; 1.64 … for nicotine patch","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}