{"ok":true,"entry":{"slug":"niacinamide","kind":"supplement","name":"niacinamide","aliases":["nicotinamide","vitamin B3 amide"],"brands_sg":["California Gold Nutrition","NOW Foods","ProHealth Longevity","Life Extension","Thorne"],"class":"vitamin B3 form","tags":["skin-hair","general"],"use_for":"nad for 400+ enzymes · limited human evidence for skin","use_after":"no timing rule on the sheet","use_duration":null,"take_with":"no food needed for flushing — nicotinamide does not flush","pros":["does not cause the flush nicotinic acid causes","almost completely absorbed, even at 3–4 g doses","rda is small — 16 mg ne men, 14 mg ne women"],"cons":["ul 35 mg/day covers both supplemental niacin forms","3,000 mg/day: nausea, vomiting, liver-toxicity signs","sg caps nicotinamide at 450 mg a day in supplements"],"dose_note":"niacin's rda is 16 mg ne a day for men and 14 mg ne for women (19+), and the fda daily value is 16 mg ne; the fnb's ul of 35 mg/day is set on nicotinic-acid flushing but applies to both supplemental forms and does not apply to people taking niacin under medical supervision; nicotinamide itself does not flush and its reported effects begin much higher — nausea, vomiting and signs of liver toxicity at 3,000 mg/day, and diarrhoea and thrombocytopenia at 500–1,500 mg/day in small hemodialysis studies; the who's pellagra protocol uses 300 mg/day nicotinamide in divided doses for 3–4 weeks; hsa caps nicotinamide in singapore health supplements at 450 mg a day (nicotinic acid: 15 mg); on skin, the nih sheet describes only pellagra's rash and an abridged cochrane review of topical acne treatments reports that no included study measured global improvement for nicotinamide, so the skin-hair tag rests on thin human evidence; a 2022 systematic review of 29 oral-nicotinamide trials reports more digestive side effects","dosage":{"ul":35,"unit":"mg","fda_dv":"16 mg NE","rda_ai":"16 mg NE men · 14 mg NE women (19+)","ul_status":"established","population":"general adult","hsa_max_daily":450},"ul_status":"established","sg_class":null,"cautions":["on isoniazid or pyrazinamide for tb — these are niacin analogs; ask your doctor","liver problems — signs of liver toxicity are reported at 3,000 mg/day nicotinamide","on dialysis — 500–1,500 mg/day caused diarrhoea and low platelets in small studies","products above 450 mg a day sit outside hsa's singapore supplement limit"],"clashes":[{"src":["nih_ods_niacin_drugs"],"note":"structural analogs of niacin; they interrupt niacin production from tryptophan and isoniazid can interfere with its conversion to nad","with":"isoniazid, pyrazinamide (tb drugs)"},{"src":["nih_ods_niacin_glucose"],"note":"this one is nicotinic acid, not nicotinamide — large nicotinic-acid doses can raise blood glucose","with":"antidiabetes medications"}],"sources":[{"id":"nih_ods_niacin_intro","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional), updated November 18, 2022 — Introduction (read via archive.org capture, see verify_notes)","quote":"Niacin is the generic name for nicotinic acid …, nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives … More than 400 enzymes require NAD to catalyze reactions in the body, which is more than for any other vitamin-derived coenzyme","accessed":"2026-08-27"},{"id":"nih_ods_niacin_absorb","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional) — Introduction, absorption","quote":"Even when taken in very high doses of 3–4 g, niacin is almost completely absorbed.","accessed":"2026-08-27"},{"id":"nih_ods_niacin_supp","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional) — Sources of Niacin, dietary supplements","quote":"Nicotinic acid in supplemental amounts beyond nutritional needs can cause skin flushing … Nicotinamide does not produce skin flushing because of its slightly different chemical structure","accessed":"2026-08-27"},{"id":"nih_ods_niacin_rda","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional) — Table 1 RDAs and the DV note","quote":"Table 1: Recommended Dietary Allowances (RDAs) for Niacin … 19+ years 16 mg NE 14 mg NE … The DV for niacin is 16 mg for adults and children age 4 years and older","accessed":"2026-08-27"},{"id":"nih_ods_niacin_ul","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional) — Health Risks from Excessive Niacin; Table 3 ULs","quote":"The FNB has established ULs for niacin that apply only to supplemental niacin … These ULs are based on the levels associated with skin flushing … applies to both forms of supplemental niacin … 19+ years 35 mg","accessed":"2026-08-27"},{"id":"nih_ods_niacin_risks","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional) — Health Risks, nicotinamide","quote":"Nicotinamide does not cause skin flushing and has fewer adverse effects than nicotinic acid … Nausea, vomiting, and signs of liver toxicity can occur with nicotinamide intakes of 3,000 mg/day","accessed":"2026-08-27"},{"id":"nih_ods_niacin_dialysis","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional) — Health Risks, hemodialysis studies","quote":"In several small studies of participants undergoing hemodialysis, the most common adverse effects from 500–1,500 mg/day nicotinamide supplementation for several months were diarrhea and thrombocytopenia (low platelet count)","accessed":"2026-08-27"},{"id":"nih_ods_niacin_pellagra","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional) — Niacin Deficiency, WHO pellagra regimen","quote":"The World Health Organization recommends treating pellagra with 300 mg/day nicotinamide in divided doses for 3–4 weeks along with a B-complex or yeast product to treat likely deficiencies in other B vitamins","accessed":"2026-08-27"},{"id":"nih_ods_niacin_drugs","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional) — Interactions: isoniazid and pyrazinamide","quote":"Isoniazid and pyrazinamide …, used to treat tuberculosis, are structural analogs of niacin and interrupt the production of niacin from tryptophan … isoniazid can interfere with niacin's conversion to NAD","accessed":"2026-08-27"},{"id":"nih_ods_niacin_glucose","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional) — Interactions: antidiabetes medications","quote":"Large doses of nicotinic acid can raise blood glucose levels by causing or aggravating insulin resistance … nicotinic acid doses of 1.5 g/day or more are most likely to increase blood glucose levels","accessed":"2026-08-27"},{"id":"mainville2022","url":"https://europepmc.org/article/MED/35134311","label":"Mainville L, Smilga AS, Fortin PR — Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis, J Cutan Med Surg 2022","quote":"We screened 4730 citations and found 29 trials (3039 patients) meeting inclusion criteria … Nicotinamide was associated with … increased risk of digestive AEs … (GRADE: weak recommendation; moderate-quality evidence)","accessed":"2026-08-27"},{"id":"cochrane_acne_2020","url":"https://europepmc.org/article/MED/33034949","label":"Liu H et al. — Evidence-based topical treatments (azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid) for acne: an abridged version of a Cochrane systematic review, J Evid Based Med 2020","quote":"There were no studies measured PGA when evaluating nicotinamide … Moderate-quality evidence was available for azelaic acid and low- to very-low-quality evidence for other topical treatments","accessed":"2026-08-27"},{"id":"hsa_prohibited","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025), Annex A rows 75–76","quote":"75. Nicotinamide Restricted use in HS and TM Maximum Daily Dose When for oral use by general adult population, the maximum recommended daily dose should not provide more than 450mg","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 and Table 4 Vitamins Limits","quote":"4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5 … Table 4: Vitamins Limits … Nicotinic acid 15mg Nicotinamide 450mg","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/vitamin-b3-niacin","label":"iHerb Singapore — Vitamin B3 (Niacin) category page, default listing order","quote":"Vitamin B3 (Niacin) … 1 - 48 of 274 results … California Gold Nutrition, NMN, 175 mg … NOW Foods, Niacinamide, 500 mg … ProHealth Longevity, NMN Pro™ 1000 … Life Extension, Vitamin B3 Niacin, 500 mg … Thorne, ResveraCel®","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Thorne","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":66}],"updated_at":"2026-08-30T17:59:38.376296+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}