{"ok":true,"entry":{"slug":"nettle","kind":"supplement","name":"stinging nettle","aliases":["Urtica dioica","nettle root","nettle leaf"],"brands_sg":["California Gold Nutrition","Frontier Co-op","Swanson Vitamins","NOW Foods","Nature's Way"],"class":"botanical","tags":["mens-health"],"use_for":"prostate symptoms in men — one small 12-week rct","use_after":null,"use_duration":"the bph trial ran 12 weeks; the rhinitis trial one month","take_with":null,"pros":["12-week rct in 60 men: intermediate effect on ipss","no side effects were seen in that bph trial","root is among the better-studied luts botanicals"],"cons":["the bph trial was small — 30 men per arm","rhinitis trial: placebo did about as well","extracts differ; one product's data may not carry over"],"dose_note":"the bph trial gave 450 mg a day of root extract for 12 weeks; the allergic-rhinitis trial gave a 150 mg root-extract tablet for one month","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"adult men","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["the bph and gulf-war trials enrolled adult men only","extract source and processing change what is in the capsule","the bph trial enrolled men already diagnosed with bph, not men self-treating symptoms"],"clashes":[],"sources":[{"id":"nettle_bph2020","url":"https://europepmc.org/article/MED/32981268","label":"Urtica dioica root extract on clinical and biochemical parameters in patients with BPH, randomized controlled trial (Karami et al., Pak J Biol Sci 2020)","quote":"Participants were 60 men with BPH … received 450 mg day-1 UDE and placebo as tablets for 12 weeks … UDE had an intermediate effect on IPSS … No side effects were seen in these patients","accessed":"2026-08-27"},{"id":"nettle_luts2025","url":"https://europepmc.org/article/MED/38411727","label":"Natural Products in the Treatment of Lower Urinary Tract Dysfunction and Infection (Lederer & Michel, Handb Exp Pharmacol 2025)","quote":"Most evidence for male LUTS is based on extracts from saw palmetto berries, stinging nettle roots, and pumpkin seeds … only limited information is available for most individual extracts","accessed":"2026-08-27"},{"id":"nettle_luts2025_extracts","url":"https://europepmc.org/article/MED/38411727","label":"Natural Products in the Treatment of Lower Urinary Tract Dysfunction and Infection (Lederer & Michel, Handb Exp Pharmacol 2025)","quote":"extracts from the same plants are likely to exhibit at least quantitative differences in potential active ingredients, which makes extrapolation of findings with one extract to those of others potentially difficult","accessed":"2026-08-27"},{"id":"nettle_rhinitis2017","url":"https://europepmc.org/article/PMC/PMC5963652","label":"Efficacy of supportive therapy of allergic rhinitis by stinging nettle root extract: a randomized, double-blind, placebo-controlled trial (Bakhshaee et al., Iran J Pharm Res 2017)","quote":"74 patients … randomly divided into 2 groups who were taken Urtica dioica 150-mg … or placebo for one month … similar effects were demonstrated by placebo as well","accessed":"2026-08-27"},{"id":"nettle_gwi2021","url":"https://europepmc.org/article/PMC/PMC8037868","label":"A placebo-controlled, pseudo-randomized, crossover trial of botanical agents for Gulf War Illness (Younger et al., Int J Environ Res Public Health 2021)","quote":"Symptom severity was not decreased from placebo with lower-dose stinging nettle (p = 0.604), but was significantly decreased with higher-dose stinging nettle (p = 0.048) … These results are in a small sample and are preliminary","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [Urtica dioica / stinging nettle not listed in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/nettle","label":"iHerb Singapore — Nettle category (default order)","quote":"California Gold Nutrition, EuroHerbs®, Nettle Root Extract … Frontier Co-op, Organic Cut & Sifted Stinging Nettle Leaf … Swanson Vitamins, Stinging Nettle Root, 500 mg … NOW Foods, Stinging Nettle Root Extract … Nature's Way, Nettle Leaf","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}