{"ok":true,"entry":{"slug":"msm","kind":"supplement","name":"msm","aliases":["methylsulfonylmethane","OptiMSM"],"brands_sg":["California Gold Nutrition","Doctor's Best","NOW Foods","Life Extension","Jarrow Formulas"],"class":"organosulfur compound","tags":["bone-joint","skin-hair"],"use_for":"joint stiffness in knee trials · skin claims are thin","use_after":"daily","use_duration":"blood levels build over about four weeks","take_with":"powder and capsule forms are both sold in sg","pros":["22-trial network analysis: top 3 for stiffness","gras status; safe under 4,845.6 mg/day per fda notice","no cyp enzyme inhibition in liver-microsome tests"],"cons":["skin evidence is mostly topical or combined products","joint trials are small and mostly short-term","alcohol sensitivity reported online; never studied"],"dose_note":"reviews describe most people tolerating up to four grams a day, and the fda gras notification covers doses under 4,845.6 mg a day; the knee osteoarthritis trial in the 2025 network analysis used 6 g a day","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["alcohol — more sensitivity is reported, but never studied","topical msm — mild skin and eye irritation reported"],"clashes":[],"sources":[{"id":"butawan2017","url":"https://europepmc.org/article/PMC/PMC5372953","label":"Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement (Butawan et al., Nutrients 2017)","quote":"health-specific outcome measures are improved with MSM supplementation, including inflammation, joint/muscle pain, oxidative stress, and antioxidant capacity … MSM is well-tolerated by most individuals at dosages of up to four grams daily, with few known and mild side effects","accessed":"2026-08-27"},{"id":"butawan2017_gras","url":"https://europepmc.org/article/PMC/PMC5372953","label":"Butawan et al., Nutrients 2017 — OptiMSM GRAS status","quote":"one MSM product (OptiMSM ® ; Bergstrom Nutrition, Vancouver, WA, USA) was granted the Generally Recognized As Safe (GRAS) status by the Food and Drug Administration in 2007","accessed":"2026-08-27"},{"id":"butawan2017_safety","url":"https://europepmc.org/article/PMC/PMC5372953","label":"Butawan et al., Nutrients 2017 — safety profile","quote":"technical reports indicate that mild skin and eye irritation have been observed when MSM is applied topically. Nonetheless, under the … (FDA) GRAS notification, MSM is considered safe at dosages under 4845.6 mg/day","accessed":"2026-08-27"},{"id":"butawan2017_skin","url":"https://europepmc.org/article/PMC/PMC5372953","label":"Butawan et al., Nutrients 2017 — section 3.7, skin quality and texture","quote":"MSM has been suggested to have therapeutic uses for the improvement of skin quality and texture by acting as a sulfur donor to keratin … four peeling sessions using pyruvic acid and MSM once every two weeks improved","accessed":"2026-08-27"},{"id":"butawan2017_pk","url":"https://europepmc.org/article/PMC/PMC5372953","label":"Butawan et al., Nutrients 2017 — serum accumulation with chronic intake","quote":"daily ingestion of MSM at 3 g by 20 healthy men for a period of four weeks … serum MSM was elevated in all men following ingestion, with a further increase at week 4 versus week 2","accessed":"2026-08-27"},{"id":"butawan2017_alcohol","url":"https://europepmc.org/article/PMC/PMC5372953","label":"Butawan et al., Nutrients 2017 — MSM and alcohol","quote":"Much anecdotal evidence from web forums and videos exists regarding chronic MSM use and increased sensitivity to alcohol … there have been no studies to date examining the effects of MSM usage on alcohol metabolism","accessed":"2026-08-27"},{"id":"du2025","url":"https://europepmc.org/article/PMC/PMC11925762","label":"Efficacy of dietary supplements for treating knee osteoarthritis: a systematic review and network meta-analysis (Du et al., Front Nutr 2025)","quote":"analysis included 22 studies with 2,777 participants … In addressing the reduction of the WOMAC score of stiffness, NEM, Aflapin, and MSM emerged as the optimal interventions … the number of RCTs included in our analysis was relatively small","accessed":"2026-08-27"},{"id":"du2025_dose","url":"https://europepmc.org/article/PMC/PMC11925762","label":"Du et al., Front Nutr 2025 — Table 1, MSM trial regimen","quote":"Kim 2006 USA MSM:21 Placebo:19 … MSM: 6 g/daily","accessed":"2026-08-27"},{"id":"kim2023_cyp","url":"https://europepmc.org/article/PMC/PMC10745882","label":"Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane (Kim et al., Molecules 2023)","quote":"CS, GCS, and MSM had no inhibitory effects on CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 … there have been reports of an interaction case where the co-administration of CS and GCS with warfarin resulted in an elevated INR","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [methylsulfonylmethane / MSM not listed in Annex A or B]","accessed":"2026-08-27"},{"id":"hsa_hs_2026","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines, GL-CHPB-3-001 Rev 020 (Jan 2026), Table 5: Minerals Limits","quote":"Table 5: Minerals Limits … Nutrient Maximum Daily Limit Boron 6.4 mg Calcium 1200 mg Chromium 0.5 mg Copper 2 mg Iodine 0.15 mg Iron 15 mg* Magnesium 350 mg Manganese 3.5 mg … Selenium 0.2 mg Zinc 15 mg","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/msm","label":"iHerb Singapore — MSM category page, Bone, Joint & Cartilage (default order, 76 results)","quote":"California Gold Nutrition, Glucosamine, Chondroitin, MSM plus Hyaluronic Acid … Doctor's Best, MSM with OptiMSM®, 1,500 mg, 120 Tablets … NOW Foods, MSM, 1,000 mg, 240 Veg Capsules … Life Extension, MSM, 100 Capsules … Jarrow Formulas, Vegan MSM","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}