{"ok":true,"entry":{"slug":"mirabegron","kind":"medication","name":"mirabegron","aliases":["Betmiga","Myrbetriq"],"brands_sg":["Betmiga"],"class":"beta-3 agonist","tags":["other"],"use_for":"prescribed for overactive bladder","use_after":"healthhub: usually once a day, with or without food","use_duration":null,"take_with":"water · tablet swallowed whole, not chewed or crushed","pros":["healthhub: for a bladder you cannot control (oab)","fda: 25 mg once daily, maximum 50 mg once daily","fda: taken with or without food in adults"],"cons":["healthhub: can raise blood pressure and heart rate","fda: not recommended if bp is severely uncontrolled","fda: angioedema of face, lips or tongue reported"],"dose_note":"the us fda label for myrbetriq (mirabegron extended-release tablets) states 'The recommended starting dosage of MYRBETRIQ is 25 mg orally once daily. If needed, increase to the maximum dosage of MYRBETRIQ 50 mg orally once daily after 4 to 8 weeks' — 50 mg a day is the adult label maximum. the sg register carries betmiga 25 mg and 50 mg prolonged-release tablets only. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["severe uncontrolled high blood pressure — fda: not recommended","trouble emptying the bladder — healthhub and fda: retention risk","liver, kidney or heart problems — healthhub: tell your professional","pregnant, planning pregnancy or breastfeeding — healthhub"],"clashes":[{"src":["fda_mira_di"],"note":"fda: mirabegron raised digoxin exposure ~27%; the lowest digoxin dose is used first and levels monitored","with":"digoxin"},{"src":["fda_mira_di"],"note":"fda: mirabegron is a moderate cyp2d6 inhibitor; narrow-therapeutic-index drugs may need monitoring","with":"medicines broken down by cyp2d6"},{"src":["fda_mira_di"],"note":"fda: small rises in warfarin exposure; the effect on repeated doses and inr is not fully investigated","with":"warfarin"},{"src":["fda_mira_warn"],"note":"fda: urinary retention reported in people also taking antimuscarinics for oab","with":"antimuscarinic oab medicines (e.g. solifenacin)"},{"src":["hh_mira_food"],"food":true,"note":"healthhub: may increase the risk of dizziness, light-headedness or drowsiness","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows; cached at /tmp/hsa_all.json and filtered locally, not re-fetched)","quote":"Both registered mirabegron products read Forensicclassification 'Prescription Only' — SIN14622P BETMIGA PROLONGED-RELEASE TABLETS 25MG and SIN14623P BETMIGA PROLONGED-RELEASE TABLETS 50MG (ATC G04BD12, Astellas)","accessed":"2026-08-27"},{"id":"hh_mira_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirabegron","label":"HealthHub (Pharmaceutical Society of Singapore) — Mirabegron: what is this medication for","quote":"Mirabegron is used to treat a condition called overactive bladder. Overactive bladder happens when you cannot control your bladder muscle … you get a strong need to urinate with leaking","accessed":"2026-08-27"},{"id":"hh_mira_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirabegron","label":"HealthHub — Mirabegron: how should I take or use this medication","quote":"This medication is usually taken once a day. You may take this medication with or without food. Do not chew or crush the tablet as this can affect the release of medication","accessed":"2026-08-27"},{"id":"hh_mira_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirabegron","label":"HealthHub — Mirabegron: what precautions should I take","quote":"You are pregnant, planning to become pregnant, or breastfeeding … You are not able to empty your bladder (urinary retention) … You have liver, kidney or heart problems … severe uncontrolled blood pressure","accessed":"2026-08-27"},{"id":"hh_mira_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirabegron","label":"HealthHub — Mirabegron: common side effects","quote":"Increased heart rate (tachycardia) … Increased in blood pressure … stop mirabegron treatment and seek medical attention immediately if your blood pressure is at 180/110mmHg … Nausea … Urinary tract infection","accessed":"2026-08-27"},{"id":"hh_mira_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirabegron","label":"HealthHub — Mirabegron: what food or medication should I avoid","quote":"Avoid drinking alcohol as it may increase the risk of dizziness, light-headedness or drowsiness.","accessed":"2026-08-27"},{"id":"fda_mira_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22MYRBETRIQ%22&limit=1","label":"US FDA label for MYRBETRIQ (mirabegron extended-release tablets), section 2 Dosage and Administration, via openFDA (effective 2024-08-01)","quote":"The recommended starting dosage of MYRBETRIQ is 25 mg orally once daily. If needed, increase to the maximum dosage of MYRBETRIQ 50 mg orally once daily after 4 to 8 weeks … Take with or without food","accessed":"2026-08-27"},{"id":"fda_mira_warn","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22MYRBETRIQ%22&limit=1","label":"US FDA label for MYRBETRIQ, section 5 Warnings and Precautions, via openFDA","quote":"not recommended for use in patients with severe uncontrolled hypertension … urinary retention has been reported to occur in patients with bladder outlet obstruction and in patients taking muscarinic antagonist medications … Angioedema of the face, lips, tongue","accessed":"2026-08-27"},{"id":"fda_mira_di","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22MYRBETRIQ%22&limit=1","label":"US FDA label for MYRBETRIQ, section 7 Drug Interactions, via openFDA","quote":"Since mirabegron is a moderate CYP2D6 inhibitor … 100 mg mirabegron increased mean digoxin Cmax from 1.01 to 1.3 ng/mL (29%) and AUC … (27%) … the lowest dose for digoxin should initially be considered","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}