{"ok":true,"entry":{"slug":"metronidazole","kind":"medication","name":"metronidazole","aliases":["Flagyl"],"brands_sg":["Nizole","Axcel Metronidazole","AA Pharma Metronidazole","Medazole","Rozex"],"class":"nitroimidazole antibiotic","tags":["antibiotic"],"use_for":"prescribed for bacterial infections — your doctor decides","use_after":"doses spaced evenly · tablets with or just after food","use_duration":null,"take_with":"water · food eases the stomach; the liquid needs none","pros":["some infections are treated with a single dose (nhs)","tablets may be taken with or just after food (nhs)","comes as tablet, liquid, gel, cream or suppository"],"cons":["a metallic or unpleasant taste is a common effect","alcohol reaction — sg advice: none for 3 days after","us label carries a carcinogenicity boxed warning"],"dose_note":"nhs: courses run from a single dose to a 2-week course, usually 2 or 3 times a day. us label, anaerobic infections: \"A maximum of 4 g should not be exceeded during a 24-hour period\". as directed on the label or by your pharmacist/doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["prior hypersensitivity to metronidazole or other nitroimidazoles — us label contraindication","liver disease or kidney disease — healthhub says tell your healthcare professional","disulfiram — nhs lists it among the medicines to check before starting","alcohol in any form, including liquid supplements — nhs flags the alcohol content"],"clashes":[{"src":["hh_metronidazole"],"food":true,"note":"sg leaflet: an unpleasant reaction — nausea, vomiting, abdominal pain, palpitations, flushing, headache","with":"alcohol (and propylene glycol)"},{"src":["nhs_metro_int"],"note":"nhs lists disulfiram among the medicines to check with a pharmacist or doctor first","with":"disulfiram"},{"src":["nhs_metro_int"],"note":"nhs lists warfarin among the medicines to check with a pharmacist or doctor first","with":"warfarin"},{"src":["nhs_metro_int"],"note":"nhs lists lithium among the medicines to check with a pharmacist or doctor first","with":"lithium"},{"src":["nhs_metro_int"],"note":"nhs: not enough information to call them safe together; liquid supplements may themselves contain alcohol","with":"herbal remedies and liquid supplements"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (official open dataset on data.gov.sg; full 5,511-row register pulled via the datastore_search API)","quote":"Forensicclassification = \"Prescription Only\" for all 9 metronidazole-containing products on the register — e.g. SIN08077P NIZOLE TABLET 200 mg, SIN10509P AXCEL METRONIDAZOLE-200, SIN02391P MEDAZOLE TABLETS, SIN08453P ROZEX GEL 0.75%. No General Sale or Pharmacy Only row.","accessed":"2026-08-27"},{"id":"nhs_metro_about","url":"https://www.nhs.uk/medicines/metronidazole/about-metronidazole/","label":"NHS Medicines A–Z — About metronidazole (brand names: Acea, Flagyl, Rozex; reviewed 31 December 2025)","quote":"Metronidazole is a type of antibiotic used to treat bacterial infections … only available on prescription. It comes as tablets, skin gel, vaginal gel, skin cream, a liquid you drink or a suppository.","accessed":"2026-08-27"},{"id":"nhs_metro_how","url":"https://www.nhs.uk/medicines/metronidazole/how-and-when-to-take-or-use-metronidazole/","label":"NHS Medicines A–Z — How and when to take or use metronidazole, 'Dosage' (reviewed 31 December 2025)","quote":"Some infections can be treated with a single dose, while other infections may need a 2-week course … you'll usually take them 2 or 3 times a day.","accessed":"2026-08-27"},{"id":"nhs_metro_take","url":"https://www.nhs.uk/medicines/metronidazole/how-and-when-to-take-or-use-metronidazole/","label":"NHS Medicines A–Z — How and when to take or use metronidazole, 'How to take tablets' and 'When to take' (reviewed 31 December 2025)","quote":"Swallow the tablets whole with a drink of water, with or just after you've eaten some food … Metronidazole liquid does not need to be taken with or after food … try to space the doses evenly.","accessed":"2026-08-27"},{"id":"nhs_metro_int","url":"https://www.nhs.uk/medicines/metronidazole/taking-metronidazole-with-other-medicines-and-herbal-supplements/","label":"NHS Medicines A–Z — Taking or using metronidazole with other medicines and herbal supplements (reviewed 31 December 2025)","quote":"Check with a pharmacist or your doctor if you're taking any other medicines, including: warfarin … lithium … disulfiram … There's not enough information to say that complementary medicines and herbal remedies are safe to take with metronidazole.","accessed":"2026-08-27"},{"id":"hh_metronidazole","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/metronidazole","label":"HealthHub (MOH Singapore / Pharmaceutical Society of Singapore) — Metronidazole medication information leaflet","quote":"Metronidazole may be taken with or after food … Avoid consuming alcohol during the course of antibiotics and for three days after completion … having a metallic or unpleasant taste in your mouth … You have liver disease, kidney disease.","accessed":"2026-08-27"},{"id":"fda_metronidazole","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=02046a22-a5eb-4bb7-bec7-e5a2aa55e142","label":"FDA DailyMed — Metronidazole tablets, USP (A-S Medication Solutions), SPL effective 18 Mar 2026; retrieved via the openFDA drug label API","quote":"A maximum of 4 g should not be exceeded during a 24-hour period … contraindicated in patients with a prior history of hypersensitivity to metronidazole or other nitroimidazole derivatives … has been shown to be carcinogenic in mice and rats.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}