{"ok":true,"entry":{"slug":"methylprednisolone","kind":"medication","name":"methylprednisolone","aliases":["Medrol"],"brands_sg":["Solu-Medrol","Lyo-Drol"],"class":"corticosteroid","tags":["other"],"use_for":"prescribed for inflammation and immune or allergic flares","use_after":"sg label: the lowest dose, for the shortest period","use_duration":null,"take_with":null,"pros":["fda: oral medrol runs from 4 mg to 48 mg a day","sg label: iv or im, dosed to the condition not the age","fda: alternate-day dosing can blunt steroid harms"],"cons":["fda: infections come easier and signs can be masked","fda: mood swings, insomnia, even psychosis reported","fda: bone thinning, high sugar, cushingoid changes"],"dose_note":"the us medrol tablet label states 'The initial dosage of MEDROL Tablets may vary from 4 mg to 48 mg of methylprednisolone per day depending on the specific disease entity being treated', adding that 'in selected patients higher initial doses may be required'; the sg solu-medrol label (sin04683p) caps the injectable regimens instead — '30 mg/kg IV over a period of at least 30 minutes … repeated every 4 to 6 hours for up to 48 hours' in life-threatening conditions, and pulses of '250 – 1000 mg/day for a few days (usually ≤ 5 days)'; as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["systemic fungal infection — fda and sg labels: contraindicated","latent tb, or contact with chickenpox or measles — fda: reactivation and severe illness reported","long courses — fda: withdrawal is gradual rather than abrupt","diabetes, peptic ulcer, high blood pressure, mood problems — fda says use with care"],"clashes":[{"src":["fda_medrol"],"note":"fda: each slows the other's metabolism; convulsions reported together","with":"ciclosporin"},{"src":["fda_medrol"],"note":"fda: inducers speed clearance, inhibitors slow it — steroid effect swings either way","with":"liver-enzyme drugs (phenobarbital, phenytoin, rifampicin; ketoconazole, troleandomycin)"},{"src":["ndf_solumedrol"],"note":"sg label: contraindicated on immunosuppressive corticosteroid doses","with":"live or live-attenuated vaccines"},{"src":["fda_medrol"],"note":"fda: the effect is variable — the label says monitor coagulation","with":"warfarin and other oral anticoagulants"},{"src":["fda_medrol"],"note":"fda: salicylate levels can fall on, and rise off, methylprednisolone","with":"high-dose aspirin"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (open dataset on data.gov.sg; same register as HSA Infosearch)","quote":"All 6 methylprednisolone products are 'Prescription Only' and all are injections: SIN04683P SOLU-MEDROL 500 mg/8 ml, SIN14594P METHYLPREDNISOLONE 500mg, and SIN17531P–SIN17534P LYO-DROL 40, 125, 500 and 1000 mg/vial (IV/IM).","accessed":"2026-08-27"},{"id":"ndf_solumedrol","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin04683p/","label":"MOH National Drug Formulary — SOLU-MEDROL FOR INJECTION 500 MG/8 ML [SIN04683P], SG product information (last updated 28 July 2026)","quote":"PRESCRIPTION ONLY MEDICINES … The lowest possible dose of corticosteroid should be used … for the minimum period … administer 30 mg/kg IV … repeated every 4 to 6 hours for up to 48 hours … pulses … 250 – 1000 mg/day.","accessed":"2026-08-27"},{"id":"fda_medrol","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22MEDROL%22+AND+openfda.route:%22ORAL%22&limit=1","label":"FDA / openFDA drug label — MEDROL (methylprednisolone) tablets, Pharmacia & Upjohn prescribing information (effective 14 Nov 2025)","quote":"The initial dosage of MEDROL Tablets may vary from 4 mg to 48 mg of methylprednisolone per day … in selected patients higher initial doses may be required … Corticosteroids … suppress the immune system and increase the risk of infection.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}