{"ok":true,"entry":{"slug":"mefenamic-acid","kind":"medication","name":"mefenamic acid","aliases":["Ponstan","Pontalon"],"brands_sg":["Pontalon","Melgesic","Mefril-250","Beafemic","Fenagesic"],"class":"NSAID","tags":["pain-fever"],"use_for":"mild to moderate pain; period pain (dysmenorrhoea)","use_after":"sg label: every 6 hours as needed, short courses only","use_duration":null,"take_with":null,"pros":["sg label names period pain as a listed indication","sg label: relief of dental, muscular and traumatic pain","five sg-registered generics — pontalon is the sg brand"],"cons":["prescription-only in sg — all 6 registered products","us label: nsaid boxed warning for heart attack, stroke","us label: nsaid gi bleeding, ulcer, perforation risk"],"dose_note":"sg label (PONTALON CAPSULE 250 MG, SIN08483P): 'the recommended initial dose is 500mg followed by 250mg every 6 hours as required and usually not to exceed one week. For dysmenorrhea, the recommended dosage is 500mg as an initial dose followed by 250mg every 6 hours, starting at the onset of menstrual pain and should not exceed for more than 2 – 3 days'. sg label (MELGESIC, SIN11071P): 'it is recommended that mefenamic acid should not be used for more than 7 days at a time'. the us label matches — '500 mg given orally as an initial dose followed by 250 mg every 6 hours as needed', 14 years and older, 'when therapy will not exceed one week (7 days)'. prescription-only in singapore, so the dose is the one the prescription sets — otherwise as directed on the label or by your doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["active ulcer or chronic inflammation of the gut — sg pontalon label lists this as a contraindication","pre-existing kidney disease — sg pontalon label says avoid; us label says avoid in advanced renal disease","asthma, hives or other allergic-type reaction after aspirin or another nsaid — us label: contraindicated","pregnancy and breastfeeding — sg melgesic label: not recommended; sg pontalon label: safe use in pregnancy has not been established"],"clashes":[{"src":["fda_mefenamic"],"note":"us label: synergistic effect on bleeding; concomitant use has an increased risk of serious bleeding compared with either drug alone — monitor for signs of bleeding","with":"warfarin and other anticoagulants, antiplatelets, ssris and snris"},{"src":["fda_mefenamic"],"note":"us label: not generally recommended because of the increased risk of bleeding; mefenamic acid is not a substitute for low-dose aspirin for cardiovascular protection","with":"aspirin (analgesic doses)"},{"src":["fda_mefenamic"],"note":"us label: nsaids may diminish the antihypertensive effect; added risk to kidney function in older, volume-depleted or renally impaired people","with":"ace inhibitors, angiotensin receptor blockers and beta-blockers"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA Register of Therapeutic Products (open data, data.gov.sg d_767279312753558cbf19d48344577084) — datastore_search API, 5,511 rows","quote":"PONTALON CAPSULE 250 mg [SIN08483P] … MEFENAMIC ACID … Prescription Only … PONTALON FILM COATED TABLET 500 mg … MELGESIC CAPSULE 250 mg … MEFRIL-250 CAPSULE 250 mg … BEAFEMIC CAPSULES 250 mg … FENAGESIC SUSPENSION 125 mg/5 ml … Prescription Only","accessed":"2026-08-27"},{"id":"ndf_pontalon_250","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08483p/","label":"MOH National Drug Formulary — PONTALON CAPSULE 250 MG [SIN08483P] (HSA-registered SG product record, updated 28 July 2026)","quote":"MEFENAMIC ACID - 250 MG … PRESCRIPTION ONLY MEDICINES … For the relief of mild to moderate pain including muscular, traumatic and dental pain, headache, postoperative and postpartum pain, and dysmenorrhea … The recommended initial dose is 500mg followed by 250mg every 6 hours as required and usually not to exceed one week … contraindicated in patients with active ulceration or chronic inflammation of either the upper or lower gastrointestinal tract … should be avoided in patients with pre-existing renal disease … Safe use of this drug in pregnancy has not been established","accessed":"2026-08-27"},{"id":"ndf_pontalon_500","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07726p/","label":"MOH National Drug Formulary — PONTALON FILM COATED TABLET 500 MG [SIN07726P] (HSA-registered SG product record, updated 28 July 2026)","quote":"MEFENAMIC ACID - 500 MG … TABLET, FILM COATED … PRESCRIPTION ONLY MEDICINES … YUNG SHIN PHARMACEUTICAL (SINGAPORE) PTE LTD … ATC code M01AG01","accessed":"2026-08-27"},{"id":"ndf_melgesic","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11071p/","label":"MOH National Drug Formulary — MELGESIC CAPSULE 250 MG [SIN11071P] (HSA-registered SG product record, updated 28 July 2026)","quote":"indicated for the relief of moderate pain when therapy will not exceed one week … also indicated for the treatment of primary dysmenorrhoea … Adults and children over 14 years - Oral, 500mg initially, followed by 250mg every 6 hours as needed … It is recommended that mefenamic acid should not be used for more than 7 days at a time … Not recommended for children under 14 years of age, women during pregnancy and lactation","accessed":"2026-08-27"},{"id":"fda_mefenamic","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d15733a9-d5fd-4d5f-86ce-e7ed8c706c7f","label":"DailyMed / FDA — MEFENAMIC ACID capsule, prescribing information (Lupin Pharmaceuticals, updated 20 April 2026)","quote":"WARNING: RISK OF SERIOUS CARDIOVASCULAR and GASTROINTESTINAL EVENTS … NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal … NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal … For management of mild to moderate pain in patient 14 years of age and older, when therapy will not exceed one week (7 days) … 500 mg given orally as an initial dose followed by 250 mg every 6 hours as needed","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}