{"ok":true,"entry":{"slug":"lisinopril","kind":"medication","name":"lisinopril","aliases":["Zestril","Prinivil"],"brands_sg":["Zestril","Lisoril","Dapril","Noperten","Hipril"],"class":"ACE inhibitor","tags":["heart-bp"],"use_for":"high blood pressure, heart failure, after a heart attack","use_after":"sg label: a single daily dose, at about the same time","use_duration":null,"take_with":"with or without food · sg label: absorption not affected","pros":["one tablet a day, with or without food","5, 10 and 20 mg strengths registered in sg","nhs: also used in heart failure and after heart attack"],"cons":["a dry cough that does not go away is common","dizziness, especially standing up quickly (nhs)","sg label: contraindicated in 2nd and 3rd trimesters"],"dose_note":"sg zestril label (sin02372p): 'The usual effective maintenance dosage is 20 mg administered in a single daily dose … The maximum dose used in long-term, controlled clinical trials was 80 mg/day'; in renal impairment 'The dosage may be titrated upward until blood pressure is controlled or to a maximum of 40 mg daily'; paediatric hypertension is capped at 'a maximum of 20 mg daily in patients weighing 20 to <50 kg, and 40 mg in patients ≥50 kg' — as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["pregnant, or pregnancy possible — sg label contraindicates the 2nd and 3rd trimesters; healthhub: stop as soon as pregnancy is known and tell the doctor","a past reaction to any ace inhibitor, or angioedema — both are sg label contraindications, hereditary or idiopathic angioedema included","kidney problems, or already on a diuretic — nhs lists kidney problems as a reason it may not suit; healthhub: potassium and kidney function may be monitored","breastfeeding — nhs: check first; a doctor may suggest enalapril, another ace inhibitor, instead"],"clashes":[{"src":["nhs_lisinopril_med"],"note":"nhs lists these among medicines that may not mix well with lisinopril","with":"other blood pressure and heart medicines"},{"src":["nhs_lisinopril_med","ndf_zestril_dose"],"note":"nhs lists diuretics; the sg label warns of symptomatic hypotension when starting in diuretic-treated patients","with":"diuretics (e.g. bendroflumethiazide)"},{"src":["nhs_lisinopril_med"],"note":"nhs lists lithium among medicines that may not mix well with lisinopril","with":"lithium"},{"src":["nhs_lisinopril_med"],"note":"nhs lists painkillers such as ibuprofen among medicines that may not mix well","with":"painkillers such as ibuprofen (nsaids)"},{"src":["ndf_zestril_ci"],"note":"sg label: contraindicated together in patients with diabetes mellitus or renal impairment (gfr <60)","with":"aliskiren-containing products"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows pulled once via the datastore_search API and filtered locally, 27 Aug 2026","quote":"ZESTRIL TABLET 10 mg SIN02372P | Prescription Only; LISORIL 5 SIN07868P; DAPRIL 10 SIN11995P; NOPERTEN 5 SIN12005P; HIPRIL-5 SIN12037P; LISINOPRIL STADA SIN11594P — all 14 lisinopril rows 'Prescription Only'; no PRINIVIL row.","accessed":"2026-08-27"},{"id":"ndf_zestril","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02372p/","label":"MOH National Drug Formulary (Singapore) — ZESTRIL TABLET 10 MG [SIN02372P], lisinopril, DCH Auriga Singapore — product info, forensic classification and method of administration","quote":"PRESCRIPTION ONLY MEDICINES … Zestril should be administered orally in a single daily dose … at approximately the same time each day. The absorption of Zestril tablets is not affected by food.","accessed":"2026-08-27"},{"id":"ndf_zestril_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02372p/","label":"MOH National Drug Formulary (Singapore) — ZESTRIL [SIN02372P], therapeutic indications","quote":"Zestril is indicated in the treatment of hypertension and in renovascular hypertension … in the management of congestive heart failure … for the treatment of haemodynamically stable patients within 24 hours of an acute myocardial infarction","accessed":"2026-08-27"},{"id":"ndf_zestril_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02372p/","label":"MOH National Drug Formulary (Singapore) — ZESTRIL [SIN02372P], posology: maintenance dose and maximums","quote":"The usual effective maintenance dosage is 20 mg administered in a single daily dose … The maximum dose used in long-term, controlled clinical trials was 80 mg/day … titrated upward … to a maximum of 40 mg daily.","accessed":"2026-08-27"},{"id":"ndf_zestril_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02372p/","label":"MOH National Drug Formulary (Singapore) — ZESTRIL [SIN02372P], contraindications","quote":"Hypersensitivity … to any other angiotensin-converting enzyme (ACE) inhibitor … Hereditary or idiopathic angioedema … Second or third trimesters of pregnancy … aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73m2)","accessed":"2026-08-27"},{"id":"healthhub_lisinopril","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/lisinopril","label":"HealthHub (MOH Singapore) — Lisinopril, Medication Information Leaflet, last reviewed 8 May 2026","quote":"Lisinopril lowers blood pressure by reducing the production of a substance called Angiotensin II … You may take this medication with or without food … a dry, annoying cough that does not go away, dizziness and lightheadedness","accessed":"2026-08-27"},{"id":"nhs_lisinopril","url":"https://www.nhs.uk/medicines/lisinopril/","label":"NHS medicines A–Z — Lisinopril (page last reviewed 4 February 2026)","quote":"Lisinopril is a type of medicine called an ACE inhibitor which makes your blood vessels relax and widen … used to treat: high blood pressure (hypertension), a recent heart attack, kidney problems caused by diabetes","accessed":"2026-08-27"},{"id":"nhs_lisinopril_med","url":"https://www.nhs.uk/medicines/lisinopril/","label":"NHS medicines A–Z — Lisinopril, taking it with other medicines, food and drink","quote":"other medicines for high blood pressure and heart problems … diuretics, such as bendroflumethiazide … anticoagulants, such as heparin … the medicine lithium … painkillers, such as ibuprofen","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}