{"ok":true,"entry":{"slug":"lisdexamfetamine","kind":"medication","name":"lisdexamfetamine","aliases":["Vyvanse"],"brands_sg":["Vyvanse"],"class":"CNS stimulant prodrug","tags":["mental-health"],"use_for":"sg label: adhd, in patients aged 6 and above","use_after":"sg label: in the morning; afternoon doses are avoided","use_duration":null,"take_with":"healthhub: with or without food · capsule swallowed whole","pros":["sg label: one morning dose covers the day","20, 30, 40, 50, 60 and 70 mg capsules registered in sg","sg label: capsule may be opened and mixed into water"],"cons":["healthhub: it may become habit-forming or be abused","sg label: not indicated or recommended for weight loss","healthhub: appetite loss and poor sleep are common"],"dose_note":"the sg vyvanse label (sin15840p) sets the adhd ceiling as \"dosage may be adjusted in increments of 10 mg or 20 mg at approximately weekly intervals up to maximum dose of 70 mg/day\", and lowers it in kidney impairment: with severe renal impairment (gfr 15 to < 30) \"the maximum dose should not exceed 50 mg/day\", and in end stage renal disease (gfr < 15) \"the maximum recommended dose is 30 mg/day\" — as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["monoamine oxidase inhibitors now or in the last 14 days — an sg label contraindication because of the risk of hypertensive crisis, and healthhub asks that this be declared","heart disease, irregular heartbeat, high blood pressure, past heart attack or stroke — healthhub asks that these be declared, and the sg label asks for cardiac assessment before starting","depression, bipolar disorder, a history of suicide, tics or drug or alcohol addiction — healthhub asks that these be declared","children and teenagers — healthhub: growth rate may be slowed down, and height and weight are monitored regularly"],"clashes":[{"src":["ndf_vyvanse_ci","healthhub_lisdex_prec"],"note":"sg label: contraindicated during and within 14 days of stopping maois, because of an increased risk of hypertensive crisis","with":"monoamine oxidase inhibitors (moclobemide, selegiline, rasagiline, linezolid, methylene blue)"},{"src":["ndf_vyvanse_int"],"note":"sg label: acidifying agents decrease blood levels, alkalinizing agents increase blood levels of amphetamine","with":"agents that alter urinary ph — acidifying (ascorbic acid) or alkalinising (sodium bicarbonate)"},{"src":["healthhub_lisdex_prec"],"note":"healthhub asks that all of these be declared, as some may affect how this medication works or cause serious drug interactions","with":"other medicines, supplements and herbal remedies generally"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 27 Aug 2026","quote":"VYVANSE CAPSULES 20/30/40/50/60/70 mg SIN15840P, SIN15841P, SIN15842P, SIN15843P, SIN15844P, SIN15845P | Lisdexamfetamine Dimesylate | Prescription Only | N06BA12 | CAPSULE — the only 6 lisdexamfetamine rows in the register","accessed":"2026-08-27"},{"id":"ndf_vyvanse","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15840p/","label":"MOH National Drug Formulary (Singapore) — VYVANSE CAPSULES 20 MG [SIN15840P], product information","quote":"LISDEXAMFETAMINE DIMESYLATE - 20 MG … Registration Number SIN15840P … Licence Holder TAKEDA PHARMACEUTICALS (ASIA PACIFIC) PTE. LTD. … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code N06BA12 … Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_vyvanse_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15840p/","label":"MOH National Drug Formulary (Singapore) — VYVANSE [SIN15840P], 1 Indications and Usage","quote":"VYVANSE is indicated for the treatment of: Attention Deficit Hyperactivity Disorder (ADHD) … Limitation of Use: VYVANSE is not indicated or recommended for weight loss","accessed":"2026-08-27"},{"id":"ndf_vyvanse_admin","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15840p/","label":"MOH National Drug Formulary (Singapore) — VYVANSE [SIN15840P], 2.2 General Instructions for Use","quote":"Take VYVANSE by mouth in the morning with or without food; avoid afternoon doses because of the potential for insomnia … Swallow VYVANSE capsules whole, or open capsules, empty and mix the entire contents with yogurt, water, or orange juice","accessed":"2026-08-27"},{"id":"ndf_vyvanse_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15840p/","label":"MOH National Drug Formulary (Singapore) — VYVANSE [SIN15840P], 2.3 Dosage for Treatment of ADHD","quote":"The recommended starting dose is 30 mg once daily in the morning in patients aged 6 and above … Dosage may be adjusted … up to maximum dose of 70 mg/day","accessed":"2026-08-27"},{"id":"ndf_vyvanse_renal","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15840p/","label":"MOH National Drug Formulary (Singapore) — VYVANSE [SIN15840P], 2.4 Dosage in Patients with Renal Impairment","quote":"In patients with severe renal impairment (GFR 15 to < 30 mL/min/1.73 m2), the maximum dose should not exceed 50 mg/day. In end stage renal disease … the maximum recommended dose is 30 mg/day","accessed":"2026-08-27"},{"id":"ndf_vyvanse_screen","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15840p/","label":"MOH National Drug Formulary (Singapore) — VYVANSE [SIN15840P], 2.1 Pre-treatment Screening","quote":"Prior to treating children, adolescents, and adults with CNS stimulants, including VYVANSE, assess for the presence of cardiac disease … To reduce the abuse of CNS stimulants including VYVANSE, assess the risk of abuse, prior to prescribing","accessed":"2026-08-27"},{"id":"ndf_vyvanse_int","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15840p/","label":"MOH National Drug Formulary (Singapore) — VYVANSE [SIN15840P], 2.5 Dosage Modifications due to Drug Interactions","quote":"Agents that alter urinary pH can impact urinary excretion and alter blood levels of amphetamine. Acidifying agents (e.g., ascorbic acid) decrease blood levels, while alkalinizing agents (e.g., sodium bicarbonate) increase blood levels","accessed":"2026-08-27"},{"id":"ndf_vyvanse_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15840p/","label":"MOH National Drug Formulary (Singapore) — VYVANSE [SIN15840P], 4 Contraindications","quote":"Known hypersensitivity to amphetamine products … Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis … Pheochromocytoma","accessed":"2026-08-27"},{"id":"healthhub_lisdex","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/lisdexamfetamine","label":"HealthHub (MOH Singapore) — Lisdexamfetamine, medication information leaflet","quote":"Lisdexamfetamine can be used to treat the symptoms of Attention-Deficit Hyperactivity Disorder (ADHD), alongside educational, social and psychological methods … Lisdexamfetamine may be taken with or without food. The capsule should be swallowed whole","accessed":"2026-08-27"},{"id":"healthhub_lisdex_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/lisdexamfetamine","label":"HealthHub (MOH Singapore) — Lisdexamfetamine, precautions","quote":"You are taking, or have stopped taking in the last 14 days, a class of medication called Monoamine oxidase inhibitors (MAOIs) … Some of them may … cause serious drug interactions","accessed":"2026-08-27"},{"id":"healthhub_lisdex_controlled","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/lisdexamfetamine","label":"HealthHub (MOH Singapore) — Lisdexamfetamine, IMPORTANT box","quote":"Lisdexamfetamine may become habit-forming or abused by some people … As Lisdexamfetamine is a controlled substance, it should be kept safely and handled responsibly, do not sell or give it to other people","accessed":"2026-08-27"},{"id":"healthhub_lisdex_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/lisdexamfetamine","label":"HealthHub (MOH Singapore) — Lisdexamfetamine, common side effects","quote":"Nausea or vomiting or stomach discomfort … Loss of appetite … Weight loss may occur during the treatment … Difficulty sleeping … Dizziness … Dry mouth … Headache or irritability … Mild nervousness","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}