{"ok":true,"entry":{"slug":"lions-mane","kind":"supplement","name":"lion's mane","aliases":["Hericium erinaceus","yamabushitake"],"brands_sg":["California Gold Nutrition","Real Mushrooms","NOW Foods","Host Defense","Swanson Vitamins"],"class":"mushroom","tags":["cognitive"],"use_for":"limited human evidence — short-term cognitive clarity","use_after":"daily","use_duration":"the trials quoted here ran 28 days to 4 weeks","take_with":null,"pros":["five rcts; four in healthy adults, benefits reported","a single 1.8 g dose sped up stroop (p = 0.005)","side effects in trials are rare and mostly mild"],"cons":["review verdict: limited effectiveness in trials","small samples, short trials, mixed results","one case report: ards after prolonged use"],"dose_note":"the trials quoted in the 2025 review used 1.8 g a day for 28 days and 10 g a day for 4 weeks; no dose is established, and the review calls the evidence base limited by sample size, duration and heterogeneity","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["mushroom allergy — a case report ties an allergic reaction to it","stomach discomfort and headache are the reported effects"],"clashes":[],"sources":[{"id":"menon2025_conclusion","url":"https://europepmc.org/article/PMC/PMC12434001","label":"Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review (Front Nutr 2025) — conclusion","quote":"HE, as a dietary supplement, shows limited effectiveness in clinical trials and is primarily used for temporary improvement in cognitive function and mental clarity","accessed":"2026-08-27"},{"id":"menon2025_rcts","url":"https://europepmc.org/article/PMC/PMC12434001","label":"Menon et al., Front Nutr 2025 — evidence base included","quote":"This review includes results from five randomized controlled trials (RCTs), 15 laboratory studies, three pilot clinical trials (PCTs), one cohort study, one case report, and one computer analysis","accessed":"2026-08-27"},{"id":"menon2025_healthy","url":"https://europepmc.org/article/PMC/PMC12434001","label":"Menon et al., Front Nutr 2025 — randomized controlled trials","quote":"Four out of five RCTs involved healthy individuals, with all trials reporting benefits and minimal side effects","accessed":"2026-08-27"},{"id":"menon2025_side","url":"https://europepmc.org/article/PMC/PMC12434001","label":"Menon et al., Front Nutr 2025 — side effects","quote":"Although commonly unreported, potential side effects of HE include stomach discomfort, headache, and allergic reactions","accessed":"2026-08-27"},{"id":"menon2025_dose","url":"https://europepmc.org/article/PMC/PMC12434001","label":"Menon et al., Front Nutr 2025 — acute and 28-day dosing trial","quote":"In a similar study evaluating both acute and 28-day chronic HE administration (1.8 g/day), a single dose produced a statistically significant improvement in Stroop task speed (p = 0.005)","accessed":"2026-08-27"},{"id":"menon2025_dose10","url":"https://europepmc.org/article/PMC/PMC12434001","label":"Menon et al., Front Nutr 2025 — 4-week 10 g/day trial","quote":"A total of 24 healthy adults participated in a placebo-controlled, single-blind, parallel longitudinal study to examine the effects of ingesting 10 g of HE daily for 4 weeks","accessed":"2026-08-27"},{"id":"menon2025_limits","url":"https://europepmc.org/article/PMC/PMC12434001","label":"Menon et al., Front Nutr 2025 — limitations of the evidence","quote":"Despite promising findings from randomized controlled trials, pilot studies, and laboratory investigations, current research is limited by sample sizes, short study durations, and heterogeneity across studies","accessed":"2026-08-27"},{"id":"menon2025_case","url":"https://europepmc.org/article/PMC/PMC12434001","label":"Menon et al., Front Nutr 2025 — case report","quote":"One case report from Japan documented acute respiratory distress syndrome in a 63-year-old male following prolonged use of HE. The report concluded that HE contains a compound capable of triggering an allergic reaction","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [Hericium erinaceus / lion's mane not listed in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/lions-mane","label":"iHerb Singapore — Lion's Mane category (default order); first 5 distinct brands: California Gold Nutrition, Real Mushrooms, NOW Foods, Host Defense, Swanson Vitamins","quote":"Organic Lion's Mane, 90 Veggie Capsules … Fungiology®, Certified Organic Lion's Mane Powder, 4.2 oz (120 g) … Lion's Mane, Mushroom Extract Powder, 120 Capsules … Lion's Mane, 500 mg, 60 Veg Capsules","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Real Mushrooms","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:38.376296+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}