{"ok":true,"entry":{"slug":"levocetirizine","kind":"medication","name":"levocetirizine","aliases":["Xyzal"],"brands_sg":["Xyzal","Levozine","Allerzal","Alerinit","Stadeltine"],"class":"non-sedating antihistamine","tags":["allergy"],"use_for":"runny nose, itchy eyes, nose or skin, allergic rash","use_after":"healthhub: when needed for symptoms · fda: in the evening","use_duration":null,"take_with":"healthhub: with or without food · swallowed whole","pros":["sg label: 5 mg once daily from 6 years upward","healthhub: a newer antihistamine, less likely to sedate","sg exemption: up to 10 tablets from a pharmacist"],"cons":["fda: somnolence, fatigue, dry mouth reported","fda: urinary retention reported — care with prostate","fda: new itching can follow stopping long-term use"],"dose_note":"the sg xyzal label (sin16028p) states 'The recommended dose is 5 mg once daily (1 film-coated tablet)' for adults and adolescents 12 and above and for children 6 to 12, and the pharmacy-supply exemption on the same record caps it at 'Maximum daily dose: 5mg · Maximum supply: 10 tablets · Min age: 12 years'; as directed on the label or by your pharmacist","dosage":null,"ul_status":null,"sg_class":"pharmacy-only","cautions":["severe kidney disease (egfr below 15, on dialysis) — sg label: contraindicated","enlarged prostate or difficulty passing urine — healthhub says tell your professional","seizures, liver or kidney problems — healthhub says tell your professional","allergy to cetirizine, hydroxyzine or piperazines — sg label: contraindicated"],"clashes":[{"src":["healthhub_levo","fda_xyzal"],"food":true,"note":"healthhub: the drowsy effect can worsen · fda: concurrent use should be avoided","with":"alcohol"},{"src":["fda_xyzal"],"note":"fda: avoid — further reductions in alertness may occur","with":"other cns depressants (sedatives, sleeping tablets)"},{"src":["healthhub_levo"],"note":"healthhub: check with a healthcare professional first, to prevent overdosing","with":"other otc antihistamines and allergy combos"},{"src":["fda_xyzal"],"note":"fda: cetirizine auc rose about 42% with ritonavir (racemate data)","with":"ritonavir"},{"src":["fda_xyzal"],"note":"fda: about 16% fall in cetirizine clearance; higher doses may do more","with":"theophylline (400 mg)"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (open dataset on data.gov.sg; same register as HSA Infosearch)","quote":"5 levocetirizine 5 mg tablets on the register: 4 'Pharmacy Only' — SIN14505P Levozine, SIN14939P ALLERZAL, SIN16312P ALERINIT, SIN16480P STADELTINE — and 1 'Prescription Only', SIN16028P XYZAL FILM-COATED TABLET 5 MG.","accessed":"2026-08-27"},{"id":"ndf_xyzal","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin16028p/","label":"MOH National Drug Formulary — XYZAL FILM-COATED TABLET 5 MG [SIN16028P], SG product information (last updated 28 July 2026)","quote":"PRESCRIPTION ONLY MEDICINES … Exemptions for Supply without Prescription: As an oral solid preparation containing not more than 5mg … Maximum daily dose: 5mg. Maximum supply: 10 tablets. Min age: 12 years … The recommended dose is 5 mg once daily.","accessed":"2026-08-27"},{"id":"healthhub_levo","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levocetirizine","label":"HealthHub (MOH Singapore / Pharmaceutical Society of Singapore) — Levocetirizine medication information leaflet (reviewed 3 Jun 2026)","quote":"belongs to a group of medicines known as antihistamines … Runny nose … Itch in the eyes, nose or skin … You may take this medication with or without food … a newer antihistamine that is less likely to cause drowsiness.","accessed":"2026-08-27"},{"id":"fda_xyzal","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22XYZAL%22&limit=1","label":"FDA / openFDA drug label — XYZAL (levocetirizine dihydrochloride) tablets and oral solution, prescribing information (effective 22 Jul 2025)","quote":"5 mg once daily in the evening … Somnolence, fatigue, and asthenia have been reported … Avoid concurrent use of alcohol or other central nervous system depressants … Urinary retention has been reported … New onset pruritus … after discontinuation.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:23.779398+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}