{"ok":true,"entry":{"slug":"lactobacillus-reuteri","kind":"supplement","name":"lactobacillus reuteri","aliases":["L. reuteri","Limosilactobacillus reuteri"],"brands_sg":["California Gold Nutrition","21st Century","Garden of Life","NOW Foods","Lemme"],"class":"probiotic","tags":["gut","immune"],"use_for":"infant colic in breastfed babies; childhood diarrhoea","use_after":null,"use_duration":"colic trials read out at day 21","take_with":"given orally to infants in the colic trials","pros":["less crying and fussing time than placebo","diarrhoea duration fell ~25 h in treatment trials","no safety concerns in non-immunocompromised people"],"cons":["colic effect insignificant in formula-fed babies","no drop in hospital-acquired diarrhoea risk","trial doses varied 4-fold between studies"],"dose_note":"paediatric trials used a daily dose of 1×10^8 to 4×10^8 colony-forming units of dsm 17938","dosage":{"ul":null,"unit":"CFU","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["severe illness or weakened immunity — higher risk of harm","premature infants — fda warned of severe or fatal infections"],"clashes":[],"sources":[{"id":"nccih_probiotics","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety","quote":"A 2018 review of 7 studies (471 participants) of probiotics for colic, 5 of which involved the probiotic Lactobacillus reuteri DSM 17938, found that this probiotic was associated with successful treatment","accessed":"2026-08-27"},{"id":"nccih_safety","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety, \"Can probiotics be harmful?\"","quote":"The risk of harmful effects from probiotics is greater in people with severe illnesses or compromised immune systems … Cases of severe or fatal infections have been reported in premature infants who were given probiotics","accessed":"2026-08-27"},{"id":"sung2018","url":"https://europepmc.org/article/MED/29279326","label":"Lactobacillus reuteri to treat infant colic: a meta-analysis (Sung et al., Pediatrics 2018)","quote":"double-blind randomized controlled trials … of L reuteri DSM17398 versus a placebo, delivered orally to infants with colic … The probiotic group averaged less crying and/or fussing time … Intervention effects … were insignificant in formula-fed infants","accessed":"2026-08-27"},{"id":"szajewska2016_reuteri","url":"https://europepmc.org/article/MED/26991503","label":"Systematic review with meta-analysis: Lactobacillus reuteri DSM 17938 for diarrhoeal diseases in children (Szajewska et al., Aliment Pharmacol Ther 2016)","quote":"In treatment trials, L. reuteri administration reduced the duration of diarrhoea (three RCTs, n = 256, mean difference, MD -24.82 h) … there was no significant reduction in the risk of nosocomial diarrhoea","accessed":"2026-08-27"},{"id":"urbanska2014","url":"https://europepmc.org/article/MED/24819885","label":"The efficacy of Lactobacillus reuteri DSM 17938 in infants and children: a review of the current evidence (Urbańska & Szajewska, Eur J Pediatr 2014)","quote":"The daily dose of L. reuteri DSM 17938 ranged from 1 × 10 8 to 4 × 10 8 colony-forming units (CFU) … There are no safety concerns with regard to the use of L. reuteri in nonimmunocompromised subjects","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/probiotics","label":"iHerb Singapore — Probiotics category page (default best-selling order)","quote":"California Gold Nutrition, LactoBif® 30 Probiotics, 60 Veggie Capsules","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), working definition and Tables 4–5","quote":"Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … Table 4: Vitamins Limits … Table 5: Minerals Limits","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Garden of Life","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":23},{"brand":"Lemme","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:39.960259+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}