{"ok":true,"entry":{"slug":"ketoconazole","kind":"medication","name":"ketoconazole","aliases":["Nizoral"],"brands_sg":["Nitozol","Ninazol","Phytoral","Pristinex","Pristine"],"class":"azole antifungal","tags":["skin"],"use_for":"sg label (shampoo): dandruff, seborrhoeic dermatitis","use_after":"sg label: left on 3 to 5 minutes, then rinsed off","use_duration":null,"take_with":"nhs: 30 minutes before other creams on the same skin","pros":["sg label: a palmful or one sachet is enough per wash","sg register: sg shampoos are all general sale list","nhs: only tiny amounts absorbed from cream or shampoo"],"cons":["us label: oral tablets carry a boxed liver warning","sg label: shampoo not for children under 12 years","nhs: too much may leave skin irritated or red"],"dose_note":"this entry covers the skin forms. the sg nizoral shampoo insert (sin04926p) sets its ceiling as a frequency, not a dose: for dandruff and seborrhoeic dermatitis \"for treatment, twice a week for 2 to 4 weeks\" then \"to prevent relapses, once a week or once every 2 weeks\", and for pityriasis versicolor \"for treatment, once a day for 1 to 3 days\"; each wash is \"a palmful or 1 sachet\" left to \"soak in for 3 to 5 minutes before rinsing\". nhs adds the cream figure — \"use the cream once or twice a day\". the oral 200 mg tablet is a different, prescription-only product with its own much higher ceiling: the us tablet label says \"the recommended starting dose … is a single daily administration of 200 mg (one tablet). if clinical responsiveness is insufficient … the dose … may be increased to 400 mg (two tablets) once daily\". as directed on the label or by your pharmacist/doctor.","dosage":null,"ul_status":null,"sg_class":"pharmacy-only","cautions":["under 12 years — the sg shampoo label says it is not recommended","known allergy to ketoconazole — the sg shampoo label's only contraindication","the oral 200 mg tablet — us boxed warning of serious hepatotoxicity, including fatal cases and cases requiring liver transplantation","the oral 200 mg tablet — us boxed warning of qt prolongation, with several medicines contraindicated alongside it"],"clashes":[{"src":["nhs_keto_int"],"note":"nhs: put the steroid cream on in the morning and the ketoconazole cream on in the evening, waiting at least 30 minutes","with":"a steroid cream such as hydrocortisone on the same skin"},{"src":["nhs_keto_int"],"note":"nhs: there's not enough information to say that complementary medicines and herbal remedies are safe to use with ketoconazole","with":"herbal remedies and supplements"},{"src":["fda_keto_oral_bw"],"note":"us tablet boxed warning: co-administration is contraindicated; may prolong qt and cause torsades de pointes","with":"oral form only — dofetilide, quinidine, pimozide, cisapride, methadone, dronedarone, ranolazine"},{"src":["fda_keto_oral_ci"],"note":"us tablet label lists these among drugs contraindicated with oral ketoconazole","with":"oral form only — lovastatin, simvastatin, colchicine, ergot alkaloids"},{"src":["fda_keto_oral_ci"],"note":"us tablet label: elevated plasma concentrations may potentiate and prolong hypnotic and sedative effects","with":"oral form only — oral midazolam, triazolam, alprazolam"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 27 Aug 2026","quote":"21 ketoconazole rows split by form: all 7 SHAMPOOS General Sale List (NIZORAL SIN04926P, NINAZOL, NITOZOL, PRISTINE, SEBIZOLE, YUCOMY, DEZOR); CREAMS split — NIZORAL SIN01117P and YUCOMY GSL, NITOZOL/PRISTINEX/ANTANAZOL/DEZOR/FORMYCO and PHYTORAL OINTMENT Pharmacy Only; all 6 oral TABLETS Prescription Only","accessed":"2026-08-27"},{"id":"ndf_nizoral","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin04926p/","label":"MOH National Drug Formulary (Singapore) — NIZORAL SHAMPOO 20 MG/G [SIN04926P], product information","quote":"KETOCONAZOLE - 20 MG/G … Dosage Form SHAMPOO … Registration Number SIN04926P … Licence Holder APEX PHARMA MARKETING PTE. LTD. … Forensic Classification GENERAL SALE LIST … ATC code D01AC08","accessed":"2026-08-27"},{"id":"ndf_nizoral_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin04926p/","label":"MOH National Drug Formulary (Singapore) — NIZORAL SHAMPOO [SIN04926P], what it is for","quote":"a medicine to treat and prevent the relapse of skin infections caused by fungi or yeasts … scales on the scalp (dandruff) … (seborrheic dermatitis) … not recommended for use in infants and children below the age of 12 years","accessed":"2026-08-27"},{"id":"ndf_nizoral_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin04926p/","label":"MOH National Drug Formulary (Singapore) — NIZORAL SHAMPOO [SIN04926P], how to use and how much","quote":"allow the product to soak in for 3 to 5 minutes before rinsing … a palmful or 1 sachet of shampoo suffices for one wash … For treatment, twice a week for 2 to 4 weeks","accessed":"2026-08-27"},{"id":"ndf_nizoral_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin04926p/","label":"MOH National Drug Formulary (Singapore) — NIZORAL SHAMPOO [SIN04926P], when not to use it","quote":"Do not use Nizoral Shampoo if you know you are hypersensitive (allergic) to it. Symptoms of hypersensitivity include itching and red skin, occurring after application","accessed":"2026-08-27"},{"id":"nhs_keto_hub","url":"https://www.nhs.uk/medicines/ketoconazole/","label":"NHS medicines A–Z — Ketoconazole: an antifungal medicine used to treat skin infections (reviewed 16 August 2024)","quote":"Ketoconazole - Brand names: Daktarin Gold, Daktarin Intensiv, Dandrazol, Nizoral … Find out how ketoconazole cream and shampoo treats fungal skin infections and how to use it","accessed":"2026-08-27"},{"id":"nhs_keto_how","url":"https://www.nhs.uk/medicines/ketoconazole/how-and-when-to-use-ketoconazole/","label":"NHS medicines A–Z — How and when to use ketoconazole","quote":"Use the cream once or twice a day on the infected skin … Use the shampoo twice a week for 2 to 4 weeks … If you use too much … it may make your skin irritated or red","accessed":"2026-08-27"},{"id":"nhs_keto_wait","url":"https://www.nhs.uk/medicines/ketoconazole/how-and-when-to-use-ketoconazole/","label":"NHS medicines A–Z — How and when to use ketoconazole, using other products on the same skin","quote":"After putting on the ketoconazole cream, wait 30 minutes before you use different products on the same area. This gives the ketoconazole time to be absorbed into your skin","accessed":"2026-08-27"},{"id":"nhs_keto_int","url":"https://www.nhs.uk/medicines/ketoconazole/using-ketoconazole-with-other-medicines-and-herbal-supplements/","label":"NHS medicines A–Z — Using ketoconazole with other medicines and herbal supplements","quote":"Only tiny amounts of ketoconazole are absorbed into your body when you use it as a cream or shampoo … put the steroid cream on in the morning and the put the ketoconazole cream on in the evening","accessed":"2026-08-27"},{"id":"fda_keto_oral_bw","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22KETOCONAZOLE%22+AND+_exists_:boxed_warning&limit=3","label":"Ketoconazole tablets (oral) — US prescribing information, openFDA drug label record, Boxed Warning","quote":"Serious hepatotoxicity, including cases with a fatal outcome or requiring liver transplantation has occurred with the use of oral ketoconazole … Co-administration of the following drugs with ketoconazole is contraindicated: dofetilide, quinidine, pimozide, lurasidone, cisapride, methadone, disopyramide, dronedarone, ranolazine","accessed":"2026-08-27"},{"id":"fda_keto_oral_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22KETOCONAZOLE%22+AND+_exists_:boxed_warning&limit=3","label":"Ketoconazole tablets (oral) — US prescribing information, Dosage and Administration","quote":"The recommended starting dose of ketoconazole tablets is a single daily administration of 200 mg (one tablet). If clinical responsiveness is insufficient within the expected time, the dose … may be increased to 400 mg (two tablets) once daily","accessed":"2026-08-27"},{"id":"fda_keto_oral_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22KETOCONAZOLE%22+AND+_exists_:boxed_warning&limit=3","label":"Ketoconazole tablets (oral) — US prescribing information, Contraindications","quote":"the following other drugs are contraindicated with ketoconazole tablets: methadone, disopyramide, dronedarone, ergot alkaloids … irinotecan, lurasidone, oral midazolam, alprazolam, triazolam, felodipine, nisoldipine, ranolazine, tolvaptan, eplerenone, lovastatin, simvastatin and colchicine","accessed":"2026-08-27"},{"id":"fda_keto_oral_ind","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22KETOCONAZOLE%22+AND+_exists_:boxed_warning&limit=3","label":"Ketoconazole tablets (oral) — US prescribing information, Indications and Usage","quote":"Ketoconazole tablets are not indicated for treatment of onychomycosis, cutaneous dermatophyte infections, or Candida infections … should be used only when other effective antifungal therapy is not available or tolerated","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:23.779398+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}